Results 191 to 200 of about 23,240 (230)

Identification of serotonin 5-HT1A receptor partial agonists in ginger

Bioorganic & Medicinal Chemistry, 2010
Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the human serotonin 5-HT(1A) receptor with significant to moderate binding affinities (K(i)=3-20 microM).
Nievergelt, Andreas, Huonker, Peter, Schoop, Roland, Altmann, Karl-Heinz, Gertsch, Jürg   +4 more
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Serotonin and psychostimulant addiction: Focus on 5-HT1A-receptors

Progress in Neurobiology, 2007
Serotonin(1A)-receptors (5-HT(1A)-Rs) are important components of the 5-HT system in the brain. As somatodendritic autoreceptors they control the activity of 5-HT neurons, and, as postsynaptic receptors, the activity in terminal areas. Cocaine (COC), amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine ("Ecstasy", MDMA) are ...
Christian P, Müller, Robert J, Carey, Joseph P, Huston, Maria A, De Souza Silva   +3 more
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Serotonin-induced 5-HT1A receptor desensitization in C6BU-1 glioma cells transfected with 5-HT1A receptor gene

Neuroscience Letters, 1995
In this study, it has been clearly demonstrated that a selective 5-hydroxytryptamine (5-HT)1A agonist, 8-OH-2-(di-n-propylamino)-tetraline (8-OH-DPAT, 1 microM) significantly inhibited forskolin (10 microM)-stimulated cyclic AMP (cAMP) accumulation in the C6BU-1 cells transfected with 5-HT1A receptor gene.
K, Saitoh, M, Mikuni, M, Ikeda, C, Yamazaki, U, Tomita, K, Takahashi   +5 more
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Clozapine is a partial agonist at cloned, human serotonin 5-HT1A receptors

Neuropharmacology, 1996
Clozapine exhibited 10-fold higher affinity than haloperidol for human 5-HT1A receptors expressed in Chinese Hamster Ovary cells (CHO-h5-HT1A) (Kis = 160 and 1910 nM respectively). Whereas haloperidol did not alter the basal binding of [35S]GTP gama S to CHO-h5HT1A membranes, clozapine stimulated it with an EC50 of 2320 nM and an efficacy of 49 ...
A, Newman-Tancredi, C, Chaput, L, Verriele, M J, Millan   +3 more
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Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system

European Journal of Nuclear Medicine, 2000
The 5-HT1A subtype of receptors for the neurotransmitter serotonin is predominantly located in the limbic forebrain and is involved in the modulation of emotion and the function of the hypothalamus. Since 5-HT1A receptors are implicated in the pathogenesis of anxiety, depression, hallucinogenic behaviour, motion sickness and eating disorders, they are ...
J, Passchier, A, van Waarde
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Modification of serotonin neuron properties in mice lacking 5-HT1A receptors

European Journal of Pharmacology, 2002
Using null mutant mice for the 5-HT1A receptor (5-HT1A-/-), extracellular electrophysiological recordings were first conducted to evaluate the impact of its genetic deletion on the firing rate of dorsal raphe 5-hydroxytryptamine (5-HT) neurons. Experiments were also done using brain slices to assess whether any compensation phenomenon had taken place ...
Maxime, Richer, René, Hen, Pierre, Blier   +2 more
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Diurnal rhythm in the levels of the serotonin 5-HT1A receptors in the crayfish eyestalk

Synapse, 2006
The crayfish eyestalk (ES) has been postulated as a possible circadian clock. 5-Hydroxytryptamine (5-HT) has been shown to play the role of a neurotransmitter or a modulator in the ES. However, little is known about the 5-HT receptors in the ES. The purpose of this work is to determine the specific binding sites using [(3)H]8-hydroxy-2(di-n-propylamino)
Gabina, Calderón-Rosete, Gonzalo, Flores, Leonardo, Rodríguez-Sosa   +2 more
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Corticosterone regulation of serotonin transporter and 5‐HT1A receptor expression in the aging brain

Synapse, 1999
Hypercortisolemia is often observed in patients suffering from major depression. As the serotonergic (5-hydroxytryptamine; 5-HT) system plays a major role in the etiology of depression, a loss of endocrine and neurotransmitter system interactions, including corticosterone regulation of 5-HT transporter (5-HTT) and 5-HT receptor expression, may underlie
L W, Maines, B J, Keck, J E, Smith, J M, Lakoski   +3 more
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Localization of 5-HT1A serotonin receptors in the cerebellum of young rats

Neurochemistry International, 1991
Abstract Previous studies have shown that functional 5-HT 1A receptors are present in the cerebellum only for the early postnatal period in rats. In order to investigate further the possible physiological significance of such a transient expression of 5-HT 1A receptors during maturation of the cerebellum, anatomical studies were performed for ...
Daniel Verge, Line Matthiessen, Genevieve Daval, Yannick Bailly, Hossein K. Kia, Michel Hamon   +5 more
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Neuroticism and serotonin 5-HT1A receptors in healthy subjects

Psychiatry Research: Neuroimaging, 2015
Neuroticism is a personality trait associated with vulnerability for mood and anxiety disorders. Serotonergic mechanisms likely contribute to neuroticism. Serotonin 5-HT1A receptors are altered in mood and anxiety disorders, but whether 5-HT1A receptors are associated with neuroticism in healthy subjects is unclear.
Hirvonen, Jussi, Tuominen, Lauri, Någren, Kjell, Hietala, Jarmo   +3 more
openaire   +5 more sources