Results 201 to 210 of about 23,240 (230)

Effect of chronic estradiol, tamoxifen or raloxifene treatment on serotonin 5-HT1A receptor

Molecular Brain Research, 2003
Numerous reports demonstrate the potency of estrogens to modulate brain function and their implications in schizophrenia and depression. The 5-HT(1A) receptor has been suggested to be implicated in depression and anxiety. Selective estrogen receptor modulators (SERMs), like tamoxifen and raloxifene, have estrogenic and/or antiestrogenic activity ...
Michelle, Landry, Thérèse, Di Paolo
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Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Bioorganic & Medicinal Chemistry Letters, 2010
Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT(1A) receptor affinities. Their design, synthesis and structure-activity relationships are described.
Aranapakam M, Venkatesan, O, Dos Santos, John, Ellingboe, Deborah A, Evrard, Boyd L, Harrison, Deborah L, Smith, Rosemary, Scerni, Geoffrey A, Hornby, Lee E, Schechter, Terrence H, Andree   +9 more
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Improving voiding efficiency in the diabetic rat by a 5‐HT1A serotonin receptor agonist

Neurourology and Urodynamics, 2011
Abstract Aims Serotonin affects micturition in the normal rat through actions not only on ascending and descending spinal pathways and supraspinal centers but also on the lumbosacral spinal cord level.
Baojun, Gu, Gang, Wu, Jieming, Si, Yuemin, Xu, Karl-Erik, Andersson   +4 more
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Population Pharmacokinetics of the Selective Serotonin 5-HT1A Receptor Partial Agonist Piclozotan

American Journal of Therapeutics, 2009
Serotonin (5-HT) and its receptors are known to play important roles in various physiological and pathophysiological processes. The 5-HT1A receptor subtype is thought to be involved in psychiatric disorders, immunomodulation, and in cerebral ischemic conditions.
John T, Mondick, Charles, Oo, Dimple, Patel, Tomomichi, Fujitani, Kahori, Shimizu, Jeffrey S, Barrett   +5 more
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Analysis of Serotonin 5-HT1A Receptors in Primary Neuronal Culture

1993
Publisher Summary Serotonin (5-hydroxytryptamine, 5-HT) is an indole monoamine that is found both in the periphery and in the central nervous system (CNS). Serotonin is recognized as a fundamentally important neurotransmitter in the brain and is strongly implicated in the pathophysiology of many neuropsychiatric disorders.
Barbara C. Swarzenski, Ann M. Benz, Janice M. Hickok, Richard D. Todd   +3 more
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Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(−)-RWAY

Synapse, 2006
[11C](R)-(-)-RWAY ([11C]2, 3, 4, 5, 6, 7-hexahydro-1{4-[1[4-(2-methoxyphenyl)-piperazinyl]]-2-phenylbutyry}-1H-azepine) is a new radioligand for imaging brain 5-HT1A receptors with positron emission tomography. In [11C](R)-(-)-RWAY, the direction of the amide bond is expected to reduce metabolism by hydrolysis while allowing easy 11C-labeling at the ...
Fumihiko, Yasuno, Sami S, Zoghbi, Julie A, McCarron, Jinsoo, Hong, Masanori, Ichise, Amira K, Brown, Robert L, Gladding, John D, Bacher, Victor W, Pike, Robert B, Innis   +9 more
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5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response

Human Psychopharmacology: Clinical and Experimental, 2000
Since its discovery 50 years ago, the role of the indoleamine 5-HT (5-hydroxytryptamine; serotonin) in the pathogenesis of depression and in the mechanism of action of antidepressant drugs has been the subject of considerable research. Advances in molecular biology and radioligand techniques have led to the functional characterisation of at least 14 ...
John F., Cryan, Brian E., Leonard
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Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation

Psychoneuroendocrinology, 2014
Previous studies have indicated that alexithymia is associated with the availability of serotonin in the brain and with the insecure attachment orientation. Inspired by the finding that the receptor 5-HT1A modulates the level of serotonin in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene modulates ...
Pingyuan, Gong, Jinting, Liu, She, Li, Xiaolin, Zhou   +3 more
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Serotonin 5-HT1A and 5-HT₃ receptors in an impulsive–aggressive phenotype.

Behavioral Neuroscience, 2009
In adult male hamsters, individual differences in offensive aggression are correlated with differences in impulsive choice and decreased serotonin (5-HT) innervation. As serotonin 1A (5-HT1A) receptors participate in the inhibition of aggression, whereas 5-HT3 receptor activation facilitates aggression, the authors hypothesized that differences in ...
M. Catalina Cervantes, Yvon Delville
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Involvement of brain serotonin 5-HT1A receptors in genetic predisposition to aggressive behavior

Neuroscience and Behavioral Physiology, 2007
Experiments were performed on Norwegian rats selected over more than 59 generations for high and low levels of high-affective defensive aggressivity and on highly aggressive (offensive) Tg8 mice with irreversible monoamine oxidase A knockout. There were significant differences in the functional state and expression of 5-HT(1A) receptors between highly ...
N K, Popova, V S, Naumenko, I Z, Plyusnina   +2 more
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