Results 211 to 220 of about 23,240 (230)

Dimerization of 8-OH-DPAT increases activity at serotonin 5-HT1A receptors

Naunyn-Schmiedeberg's Archives of Pharmacology, 1998
[35S]GTPgammaS binding responses can be used to measure differences between the intrinsic activity of ligands at human 5-hydroxytrypamine-(1A) (h 5-HT1A) receptors expressed in recombinant cell lines. The maximal [35S]GTPgammaS binding response to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was lower than that to 5-HT in a recombinant C6-glial ...
P J, Pauwels, D S, Dupuis, M, Perez, S, Halazy   +3 more
openaire   +2 more sources

Serotonin, 5-HT1A serotonin receptors and proliferation of lymphocytes in major depression patients.

Neuroimmunomodulation, 2007
Serotonin receptors are present in lymphocytes and might be related to the functionality of these cells in health and in pathology. The serotonergic system is affected in the brain and in peripheral immune cells of depressed patients. The objectives of this work were to evaluate the basal proliferation of lymphocytes, the response to the mitogen ...
Alfonso, González, Fili, Fazzino, Mirta, Castillo, Salvador, Mata, Lucimey, Lima   +4 more
openaire   +1 more source

PET radiotracers for molecular imaging of serotonin 5-HT1A receptors.

Current medicinal chemistry, 2014
Serotonin and its various receptors are involved in numerous brain functions and neuropsychiatric disorders. The 5-HT1A family is the best characterized subtype of the fourteen currently known 5-HT receptors. The 5-HT1A receptor is closely involved in the pathogenesis of anxiety, depression, epilepsy and eating disorders and therefore is an important ...
Billard, T., Le Bars, D., Zimmer, L.
openaire   +2 more sources

Nowi selektywni funkcjonalnie agoniści receptora serotoninowego 5-HT1A

2018
Przedmiotem rozprawy doktorskiej było opracowanie nowej generacji selektywnych funkcjonalnie agonistów receptora serotoninowego typu 5-HT1A, o istotnym znaczeniu w poszukiwaniu terapii schorzeń psychiatrycznych i neurodegeneracyjnych. Zaprojektowano, przy wsparciu modelowania molekularnego, oraz otrzymano drogą syntezy chemicznej bibliotekę 65 nowych ...
openaire   +1 more source

Serotonin 5-HT1A Receptor Agonists as Antidepressants

CNS Drugs, 1998
Jon F. Heiser, Charles S. Wilcox
openaire   +1 more source

Serotonin 5-HT1A Receptor Agonists in Oxidative Stress and Retinal Disease

2012
Pharmacologic agents known as neuroprotectants aim to prevent ­neuronal death by upregulating endogenous protective pathways or inhibiting death mechanisms, and are being evaluated as potential therapeutics for several diseases of the brain and retina.
Robert Collier, Glenn Noronha, Carmelo Romano   +2 more
openaire   +1 more source

Serotonin neurotransmission in 5-HT1a and 5-HT1b receptor knockout mice

2001
Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.
openaire   +1 more source

Serotonin2C Receptors and Serotonin2C Receptor-Mediated Phosphoinositide Hydrolysis in the Brain of Alcohol-Preferring and Alcohol-Nonpreferring Rats

Alcoholism: Clinical and Experimental Research, 1996
Subhash C Pandey, Lawrence Lumeng, T -K Li   +2 more
exaly  

Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors

Journal of Neurochemistry, 2006
Sylvia Navailles, Dimitri Ryczko, Umberto Spampinato   +2 more
exaly  

Strain‐dependent serotonin neuron feedback control: role of serotonin2Creceptors

Journal of Neurochemistry, 2010
Roberto W Invernizzi
exaly