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Receptors | Angiotensin Receptors
, 2021 The renin-angiotensin-aldosterone system (RAS) is a vital hormone-receptor system that regulates cardiovascular and renal functions. In this article, we discuss exciting new findings in the RAS field. Recently solved active state crystal structures of Angiotensin II type 1 (AT1R) and type 2 receptor (AT2R) helped in understanding receptor activation ...
Triveni R. Pardhi, Sadashiva S. Karnik
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An Introduction to Receptors and Receptor Disorders
Experimental Biology and Medicine, 1979 SummaryIn the last decade reliable methods have been introduced to quantitate and characterize receptors for hormones and other biologically interesting ligands. Applied initially to hormone receptors on malignant cells and to androgen-resistant and insulin-resistant states, these methods have led to the identification of many disease processes where ...
J. Roth +8 more
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Truncated human endothelin receptor A produced by alternative splicing and its expression in melanoma [PDF]
, 1998 In this study, reverse transcriptase polymerase chain reaction was used to amplify human endothelin receptor A (ETA) and ETB receptor mRNA. A truncated ETA receptor transcript with exons 3 and 4 skipped was found.
Berry, PA +5 more
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Scientific Reports, 2017 The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in various ...
S. J. Desmet +9 more
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Nature Communications, 2023 The class Frizzled of G protein-coupled receptors (GPCRs), consisting of ten Frizzled (FZD1-10) paralogs and Smoothened, remains one of the most enigmatic GPCR families.
Lukas Grätz +8 more
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Scientific Reports, 2017 The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta +12 more
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IL-1α and TNF-α Down-Regulate CRH Receptor-2 mRNA Expression in the Mouse Heart [PDF]
, 2001 Two receptors (CRH receptor type 1 and CRH receptor type 2) have been identified for the stress-induced neuropeptide, CRH and related peptides, urocortin, and urocortin II.
Coste, Sarah C. +4 more
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Cold Spring Harbor Perspectives in Biology, 2010 Of the established Ca2+-mobilizing messengers, NAADP is arguably the most tantalizing. It is the most potent, often efficacious at low nanomolar concentrations, and its receptors undergo dramatic desensitization. Recent studies have identified a new class of calcium-release channel, the two-pore channels (TPCs), as the likely targets for NAADP ...
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Harmonic oscillator model of the insulin and IGF1 receptors’ allosteric binding and activation
Molecular Systems Biology, 2009 The insulin and insulin‐like growth factor 1 receptors activate overlapping signalling pathways that are critical for growth, metabolism, survival and longevity.
Vladislav V Kiselyov +3 more
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Expression of the insulin-like growth factor-II/mannose-6-phosphate receptor in multiple human tissues during fetal life and early infancy [PDF]
, 1992 The insulin like growth factor-II/mannose-6-phosphate (IGF-II/M6P) receptor has been detected in many cells and tissues. In the rat, there is a dramatic developmental regulation of IGF-II/M6P receptor expression, the receptor being high in fetal and ...
Eisenmenger, Wolfgang +5 more
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