Results 81 to 90 of about 3,511,004 (317)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance [PDF]

, 2001
Toshimasa Yamauchi, Junji Kamon, Hironori Waki, Koji Murakami, Kiyoto Motojima, Kajuro Komeda, Tomohiro Ide, Naoto Kubota, Yasuo Terauchi, Kazuyuki Tobe, Hiroshi Miki, Atsuko Tsuchida, Yasuo Akanuma, Ryozo Nagai, Satoshi Kimura, Takashi Kadowaki   +15 more
openalex   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

PancrESS – a meta-analysis resource for understanding cell-type specific expression in the human pancreas

BMC Genomics
Background The human pancreas is composed of specialized cell types producing hormones and enzymes critical to human health. These specialized functions are the result of cell type-specific transcriptional programs which manifest in cell-specific gene ...
David Sturgill, Li Wang, H. Efsun Arda
doaj   +1 more source

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. [PDF]

, 1996
Paul Ponath, Suofu Qin, T W Post, Jian-Feng Wang, Lin Wu, N P Gerard, Walter Newman, Craig Gerard, Charles R. Mackay   +8 more
openalex   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Allosteric Receptors after 30 Years [PDF]

, 1998
Jean-Pierre Changeux, Stuart J Edelstein
openalex   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Structures of adenosine receptor A2BR bound to endogenous and synthetic agonists

Cell Discovery, 2022
Hongmin Cai, Youwei Xu, Shimeng Guo, Xinheng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H. Eric Xu, Xin Xie, Yi Jiang   +12 more
doaj   +1 more source