Results 301 to 310 of about 148,079 (360)

Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts.

Biochemical and Biophysical Research Communications, 2003
Receptor activator of nuclear factor kappa B (RANK) is a tumor necrosis factor receptor (TNFR) family protein that plays an important role in the regulation of bone and immune systems. Cellular responses to RANK ligand (RANKL) and the signal transduction pathways of RANK have been well characterized in osteoclasts and osteoclast precursor cells.
Z. Lee, Hong-Hee Kim
semanticscholar   +3 more sources

Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa B

The Journal of Pathology, 2007
AbstractRANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal and pathological conditions. Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well as OPG, and functional RANK is expressed in a murine osteosarcoma cell line.
Kanji Mori, Kanji Mori, B. L. Goff, B. L. Goff, M. Berreur, M. Berreur, A. Riet, A. Riet, Anne Moreau, Frédéric Blanchard, Frédéric Blanchard, Catherine Chevalier, I. Guisle-Marsollier, Jean J. Leger, J. Guicheux, M. Masson, François Gouin, François Gouin, F. Redini, F. Redini, Dominique Heymann, Dominique Heymann   +21 more
semanticscholar   +3 more sources

Expression and Distribution of Receptor Activator of Nuclear Factor Kappa B, Receptor Activator of Nuclear Factor Kappa B Ligand, and Osteoprotegerin in Periradicular Cysts.

Journal of Endodontics, 2015
The receptor activator of nuclear factor kappa B (RANK)-RANK ligand (RANKL)-osteoprotegerin (OPG) system is important in osteoclastogenesis and may play a role in the development of apical periodontitis. This immunohistochemical study evaluated the distribution of the expression of these regulators of bone resorption in periradicular cysts.Biopsy ...
L. Armada, P. Marotta, F. Pires, J. Siqueira   +3 more
semanticscholar   +3 more sources

Receptor Activator of Nuclear Factor kappa-B Ligand is Not Regulated During Chronic Osteomyelitis in Pigs.

Journal of Comparative Pathology, 2020
Bone loss is a major complication of osteomyelitis and from numerous in-vitro studies, it has been concluded that the bone lysis is caused by elevated expression of the receptor activator of nuclear factor κB ligand (RANKL), leading to increased ...
F. Lüthje, F. Lüthje, Kerstin Skovgaard, Henrik Jeldtoft Jensen, S. A. Blirup-Plum, N. L. Henriksen, Bent Aalbæk, L. K. Jensen   +7 more
semanticscholar   +4 more sources

Interleukin‐12 Induces Receptor Activator of Nuclear Factor‐Kappa B Ligand Expression by Human Periodontal Ligament Cells

Journal of Periodontology, 2017
Background: Increased level of proinflammatory cytokine interleukin (IL)‐12 correlates with the severity of periodontitis. Yet, a possible role of IL‐12 in periodontal disease has not been clarified. The aim of this study is to investigate whether IL‐12 affects expression of receptor activator of nuclear factor‐kappa B (NF‐κB) ligand (RANKL), a potent ...
B. Issaranggun Na Ayuthaya, V. Everts, P. Pavasant   +2 more
semanticscholar   +3 more sources

Exendin‐4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor‐kappa B and osteoprotegerin signaling pathway

Journal of Cellular Biochemistry, 2022
The capability of mesenchymal stem cells (MSCs) to repair bone damage and defects has long been investigated. The receptor activator of nuclear factor‐kappa B (RANK), its ligand (RANKL) and the decoy receptor osteoprotegerin (OPG) axis is crucial to keep
S. Habib, Mohamed M. Kamal, S. El-Maraghy, Mahmoud A. Senousy   +3 more
semanticscholar   +1 more source

Influence of receptor activator of nuclear factor kappa B on human aortic valve myofibroblasts

Experimental and Molecular Pathology, 2005
Calcific aortic valve stenosis, the main heart valve disease in the elderly, is based on progressive calcification and fibrous thickening of the valve. Several reports addressed the pathogenesis of tissue calcification in this disorder, but few data exist on the molecular mechanisms of the fibrosis and remodeling of the extracellular matrix.
Jens J, Kaden, Carl-Erik, Dempfle, Refika, Kiliç, Aslihan, Sarikoç, Siegfried, Hagl, Siegfried, Lang, Martina, Brueckmann, Martin, Borggrefe   +7 more
openaire   +2 more sources

Regulation of Osteoblast Migration Involving Receptor Activator of Nuclear Factor‐kappa B (RANK) Signaling

Journal of Cellular Physiology, 2015
Bone remodeling requires osteoclast activation, resorption, and reversal, prior to osteoblast migration into the bone pit. The Receptor Activator of NF‐κB (RANK) signaling pathway plays an important role in bone remodeling. Two components of the RANK signaling pathway, RANK Ligand (RANKL) and the decoy receptor Osteoprotegerin (OPG), are expressed ...
Diana, Golden, Elizabeth A, Saria, Marc F, Hansen   +2 more
openaire   +2 more sources

Serum level of receptor activator of nuclear factor kappa‐B ligand in patients with psoriasis

International Journal of Dermatology, 2015
AbstractBackgroundPsoriasis usually precedes the onset of psoriatic arthritis by an average of 10 years in about 70% of patients. Receptor activator of nuclear factor kappa‐B ligand (RANKL) is a natural and necessary surface‐bound molecule, which is a ligand for osteoprotegrin and functions as a key factor for osteoclast differentiation and activation ...
Tarek E, Amin, Nashwa N, ElFar, Nahla R, Ghaly, Mona M, Hekal, Azza M, Hassan, Hanan M, Elsaadany   +5 more
openaire   +2 more sources

EP891 Receptor activator of nuclear factor kappa-B ligand expression predicts ovarian cancer outcome

ePoster, 2019
Introduction/Background The receptor activator of nuclear factor-κB (RANK) pathway, activated by RANK ligand (RANKL), critically controls bone metabolism and modulates tumour immune response. Denosumab, a neutralizing RANKL antibody, exerts tumour-suppressive effects in mice and humans. Herein, the relevance of RANK signalling was investigated for the
J Kögl, V Wieser, S Sprung, H Fiegl, C Marth, AG Zeimet   +5 more
openaire   +1 more source