Results 1 to 10 of about 266,503 (301)

Receptor activity‐modifying protein 1 regulates mouse skin fibroblast proliferation via the Gαi3-PKA-CREB-YAP axis [PDF]

Cell Communication and Signaling, 2022
Background Skin innervation is crucial for normal wound healing. However, the relationship between nerve receptors and wound healing and the intrinsic mechanism remains to be further identified.
Siyuan Yin, Ru Song, Jiaxu Ma, Chunyan Liu, Zhenjie Wu, Guoqi Cao, Jian Liu, Guang Zhang, Huayu Zhang, Rui Sun, Aoyu Chen, Yibing Wang   +11 more
doaj   +4 more sources

CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1. [PDF]

Br J Pharmacol, 2017
Background and PurposeCGRP is a potent vasodilator and nociceptive neuropeptide linked to migraine. CGRP receptors are heterodimers of receptor activity modifying protein 1 (RAMP1) and either calcitonin receptor‐like receptor (CLR; forms canonical CGRP receptor) or calcitonin receptor (CT receptor; forms AMY1 receptor).
Bohn KJ, Li B, Huang X, Mason BN, Wattiez AS, Kuburas A, Walker CS, Yang P, Yu J, Heinz BA, Johnson KW, Russo AF.   +11 more
europepmc   +10 more sources

Characterization of Antibodies against Receptor Activity-Modifying Protein 1 (RAMP1): A Cautionary Tale. [PDF]

Int J Mol Sci, 2022
Calcitonin gene-related peptide (CGRP) is a key component of migraine pathophysiology, yielding effective migraine therapeutics. CGRP receptors contain a core accessory protein subunit: receptor activity-modifying protein 1 (RAMP1). Understanding of RAMP1 expression is incomplete, partly due to the challenges in identifying specific and validated ...
Hendrikse ER, Rees TA, Tasma Z, Garelja ML, Siow A, Harris PWR, Pawlak JB, Caron KM, Blakeney ES, Russo AF, Sowers LP, Lutz TA, Le Foll C, Walker CS, Hay DL.   +14 more
europepmc   +4 more sources

Neuronal receptor activity-modifying protein 1 promotes energy expenditure in mice. [PDF]

Diabetes, 2011
OBJECTIVE Receptor activity–modifying proteins (RAMPs) 1, 2, and 3 are unusual accessory proteins that dictate the binding specificity of two G protein–coupled receptors involved in energy homeostasis: calcitonin gene–related peptide (CGRP) and amylin receptors.
Zhang Z, Liu X, Morgan DA, Kuburas A, Thedens DR, Russo AF, Rahmouni K.   +6 more
europepmc   +4 more sources

Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line. [PDF]

PLoS ONE, 2014
The Calcium Sensing Receptor (CaSR) plays a role in calcium homeostasis by sensing minute changes in serum Ca(2+) and modulating secretion of calciotropic hormones. It has been shown in transfected cells that accessory proteins known as Receptor Activity
Aditya J Desai, David J Roberts, Gareth O Richards, Timothy M Skerry   +3 more
doaj   +2 more sources

Receptor activity-modifying protein modulation of parathyroid hormone-1 receptor function and signaling

Frontiers in Pharmacology
IntroductionReceptor activity-modifying proteins (RAMPs) are known to modulate the pharmacology and function of several G-protein-coupled receptors (GPCRs), including the parathyroid hormone 1 receptor (PTH1R).
Paris Avgoustou, Ameera B. A. Jailani, Aditya J. Desai, David J. Roberts, Ewan R. Lilley, Grant W. Stothard, Timothy M. Skerry, Gareth O. Richards   +7 more
doaj   +4 more sources

Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract. [PDF]

Peptides, 2012
Calcitonin gene-related peptide (CGRP) exerts its diverse effects on vasodilation, nociception, secretion, and motor function through a heterodimeric receptor comprising of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1).
Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A.   +5 more
europepmc   +4 more sources

Post-endocytic Sorting of Calcitonin Receptor-like Receptor and Receptor Activity-modifying Protein 1 [PDF]

Journal of Biological Chemistry, 2007
Calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 1 (RAMP1) comprise a receptor for calcitonin gene-related peptide (CGRP). Although CGRP induces endocytosis of CLR/RAMP1, little is known about post-endocytic sorting of these proteins.
Graeme S, Cottrell, Benjamin, Padilla, Stella, Pikios, Dirk, Roosterman, Martin, Steinhoff, Eileen F, Grady, Nigel W, Bunnett   +6 more
  +8 more sources

Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis

Reproductive Biology and Endocrinology, 2021
Background Accumulating data indicate that sensory nerve derived neuropeptides such as substance P and calcitonin gene related-protein (CGRP) can accelerate the progression of endometriosis via their respective receptors, so can agonists to their ...
Xiaofang Xu, Xianjun Cai, Xishi Liu, Sun-Wei Guo   +3 more
doaj   +1 more source

Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine

Frontiers in Pharmacology, 2022
Migraine is a complex neurovascular disease, which seriously affects the quality of life in patients. This study aimed to evaluate the effect of Xiongmatang (XMT) extract on rats with migraine induced by inflammatory soup and the underlying mechanisms ...
Dingding Liu, Lulu Chang, Jingru Wang, Qiang Zhu, Ning Jiang, Mudassar Azhar, Ayaz Ahmed, Guirong Zeng   +7 more
doaj   +1 more source