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Expression of functional receptor activity modifying protein 1 by airway epithelial cells with dysregulation in asthma

Journal of Allergy and Clinical Immunology, 2010
Epithelial cell expression of calcitonin gene-related peptide (CGRP) is a feature of provoked asthma. Receptor activity modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor combine to form the CGRP1 receptor.To determine whether functional RAMP1 is expressed by airway epithelial cells and whether there are alterations in asthma.BEAS-2B
Kandace, Bonner   +4 more
openaire   +2 more sources

Receptor activity‐modifying protein 1 regulates the phenotypic expression of BMSCs via the Hippo/Yap pathway

Journal of Cellular Physiology, 2019
AbstractReceptor activity‐modifying protein 1 (RAMP1) might be a critical regulator during bone wound healing. However, the roles and mechanisms of RAMP1 in osteogenesis remain unclear. Here, we aimed to elucidate the role of RAMP1 and explore the effects of Yes‐associated protein 1 (Yap1), an effector of the Hippo/Yap pathway, in this process. We used
Qin Zhang   +8 more
openaire   +2 more sources

The calcitonin receptor-like receptor/receptor activity-modifying protein 1 heterodimer can function as a calcitonin gene-related peptide-(8–37)-sensitive adrenomedullin receptor

European Journal of Pharmacology, 2002
The receptor activity-modifying protein (RAMP)/calcitonin receptor-like (CRL) receptor heterodimer is thought to function as a receptor for either a calcitonin gene-related peptide (CGRP) (CRL receptor/RAMP1) or adrenomedullin (CRL receptor/RAMP2 or -3), depending on the RAMP isoform present.
Yasuko, Nagoshi   +6 more
openaire   +2 more sources

The influence of receptor activity–modifying protein‐1 overexpression on angiogenesis in mouse brain capillary endothelial cells

Journal of Cellular Biochemistry, 2018
AbstractReceptor activity–modifying protein‐1 (RAMP1) is highly expressed in the heart and vasculature, indicating that it might be related to the vascular system. However, the effects of RAMP1 on angiogenesis and the intrinsic mechanisms underlying this process remain unclear.
Qin Zhang   +6 more
openaire   +2 more sources

Aspartate69 of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2

Biochemical and Biophysical Research Communications, 2004
The calcitonin-like receptor (CLR) associated with receptor-activity-modifying proteins (RAMP) 1 or -2 recognizes calcitonin gene-related peptide (CGRP) and adrenomedullin (AM), respectively. The amino acid sequence CNRTWDGWLCW corresponding to residues 64-74 in the extracellular N-terminus of the CLR is conserved. The Asp(69) (D(69)) is present in all
Lars M, Ittner   +5 more
openaire   +2 more sources

Haplotype-based, case–control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension

Journal of Human Hypertension, 2017
The adrenomedullin receptor is a complex molecule that comprises the calcitonin-receptor-like receptor (CRLR) and the receptor-activity-modifying protein (RAMP). RAMP1 is a vasodilation factor, and RAMP1-deficient mice (RAMP1(-/-)) exhibit inflammatory responses with a significant transient increase in serum calcitonin-gene-related peptide levels and ...
T, Nakayama   +8 more
openaire   +2 more sources

[Manual Acupuncture Stimulation Regulates Expression of Receptor Activity-modifying Protein 1 and 5-HT 1 D Receptor Proteins and Genes in Migraine Rats].

Zhen ci yan jiu = Acupuncture research, 2019
To observe the effect of liver-soothing and mental-activity-regulating (LSMAR) needling on the expression of receptor activity-modifying protein 1 (RAMP 1, receptor of calcitonin gene-related peptide), 5-hydroxytryptamine 1 D receptor(5-HT 1 DR) in the spinal trigeminal nucleus (STN) and midbrain in migraine rats, so as to explore its underlying ...
Meng-Meng, Wang   +6 more
openaire   +1 more source

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung   +2 more
exaly  

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