Results 21 to 30 of about 266,503 (301)

Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. [PDF]

PLoS ONE, 2017
Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function.
Mahita Kadmiel, Brooke C Matson, Scott T Espenschied, Patricia M Lenhart, Kathleen M Caron   +4 more
doaj   +1 more source

RAMP1 as a novel prognostic biomarker in pan-cancer and osteosarcoma.

PLoS ONE, 2023
Receptor activity modifying protein 1 (RAMP1) facilitates the localization of the calcitonin-like receptor (CLR) to the plasma membrane, but its role in osteosarcoma (OS) remains unclear.
Long Xie, Weiwei Xiao, Hangqi Fang, Guoqiang Liu   +3 more
doaj   +1 more source

Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice. [PDF]

PLoS ONE, 2014
Asthma is a chronic inflammatory disease affecting the lung, characterized by breathing difficulty during an attack following exposure to an environmental trigger. Calcitonin gene-related peptide (CGRP) is a neuropeptide that may have a pathological role
Manyu Li, Sarah E Wetzel-Strong, Xiaoyang Hua, Stephen L Tilley, Erin Oswald, Matthew F Krummel, Kathleen M Caron   +6 more
doaj   +1 more source

Adrenomedullin is an Important Pathological Mediator in Progression of Chronic Neuropathic Pain

Frontiers in Bioscience-Landmark, 2022
Background: The characterization of neuropathic pain is maladaptive plasticity within the nociceptive system. Multiple alterations contribute to complex pain phenotypes. Adrenomedullin (AM) has been documented to be a pain mediator.
Chunmei Wang, Yaping Xue, Qiuhua Lu, Yonghui Shi, Wei Tang, Dongmei Wang   +5 more
doaj   +1 more source

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach [PDF]

, 2013
The calcitonin gene-related peptide (CGRP) receptor is a complex of a calcitonin receptor-like receptor (CLR), which is a family B G-protein-coupled receptor (GPCR) and receptor activity modifying protein 1.
Alex C. Conner, Barwell J, Bruck Taddese, Christopher A. Reynolds, Conner AC, David R. Poyner, Debbie L. Hay, Harriet A. Watkins, James Barwell, Kevin J. Smith, Michael. J. Woolley, Urano D, Watkins HA, Z. Gamze Karakullukcu   +13 more
core   +2 more sources

Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]

, 1997
Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A., Li, Jun, Zagotta, William N.   +2 more
core   +1 more source

Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis

Advanced Science, 2022
Sensory nerves are long being recognized as collecting units of various outer stimuli; recent advances indicate that the sensory nerve also plays pivotal roles in maintaining organ homeostasis.
Bo Hu, Xiao Lv, Leixin Wei, Yunhao Wang, Genjiang Zheng, Chen Yang, Fazhi Zang, Jianxi Wang, Jing Li, Xiaodong Wu, Zhihao Yue, Qiangqiang Xiao, Zengwu Shao, Wen Yuan, Jinsong Li, Peng Cao, Chen Xu, Huajiang Chen   +17 more
doaj   +1 more source

Cloning and transcriptional analysis of the mouse receptor activity modifying protein-1 gene promoter [PDF]

BMC Molecular Biology, 2005
Abstract Background Receptor activity modifying protein-1 (RAMP-1) is a single transmembrane-domain protein required for the functional expression of calcitonin gene-related peptide (CGRP) receptors. To date, little is known about the molecular mechanism(s) that activate/inhibit RAMP-1 gene expression ...
Pondel, Marc D, Mould, Richard
openaire   +2 more sources

Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]

, 2015
Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn, Andrade-Gordon, Andrews, Bae, Bae, Bae, Bernatowicz, Capodanno, Chackalamannil, Chandra C. Ghosh, Chris Dockendorff, Christian G. Peters, Connolly, Covic, Dockendorff, Dowal, Garcia, Griffin, James R. Dilks, Karen De Ceunynck, Kataoka, Katritch, Knezevic, Kosoglou, Kosoglou, Lee, Matsuoka, May, McCoy, Mingdong Huang, Moers, Morrow, Mosnier, Mosnier, Mosnier, Nicholls, Offermanns, Omozuanvbo Aisiku, O’Callaghan, O’Donoghue, Riewald, Riewald, Robert Flaumenhaft, Salchow, Samir M. Parikh, Susanna F. Fustolo-Gunnink, Swift, Taylor, Tressel, Tricoci, Vanhoorelbeke, Wiviott, Zhang   +52 more
core   +2 more sources

Screening of potential GCMS derived antimigraine compound from the leaves of Abrus precatorius Linn to target “calcitonin gene related peptide” receptor using in silico analysis

Food Science and Human Wellness, 2019
Calcitonin receptor-like receptor (CRLR) is a human protein, that produces a calcitonin gene-related peptide receptor (CGRP) when associates with human receptor activity-modifying protein-1 (HRAMP1).
Parthasarathy V., Ajay Kumar T.V
doaj   +1 more source