Results 51 to 60 of about 266,503 (301)

Management of Osteoarthritis with Avocado/Soybean Unsaponifiables. [PDF]

, 2015
Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the worlds population living longer,
Bhatti, Simi, Christiansen, Blaine, Emami, Shahin, Goudarzi, Ramin   +3 more
core   +1 more source

Possible sites of action of the new calcitonin gene-related peptide receptor antagonists

Therapeutic Advances in Neurological Disorders, 2010
Migraine is considered a neurovascular disease affecting more than 10% of the general population. Currently available drugs for the acute treatment of migraine are vasoconstrictors, which have limitations in their therapeutic use.
Sajedeh Eftekhari, Lars Edvinsson
doaj   +1 more source

Receptor activity–modifying protein 3 enhances GLP-1-mediated insulin secretion

Journal of Biological Chemistry
Abstract The targeting of the Glucagon-like peptide-1 receptor (GLP-1R) for diabetes and obesity is not a novel strategy, with recent therapeutics showing efficacy in weight loss and glycaemic control. However, they are also associated with side effects, including gastrointestinal disruptions and pancreatitis.
Abigail Pearce, Poonam Kumari, Claudia M. Sisk, Matthew Harris, Ho Yan Yeung, Sabrina Winfield, Kathleen M. Caron, Graham Ladds   +7 more
openaire   +3 more sources

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO, CONTE, MICHELA, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, FABBRINI, Giovanni, GALLO, Andrea, GRECO, Antonio, INGHILLERI, Maurizio, RIZZO, MARIA IDA, ROSATO, CHIARA   +9 more
core   +1 more source

Rheumatoid arthritis [PDF]

, 2016
Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor ...
Aletaha, Daniel, McInnes, Iain B., Smolen, Josef S.   +2 more
core   +1 more source

RIPK1 is aberrantly expressed in multiple B-cell cancers and implicated in the underlying pathogenesis

Discover Oncology, 2023
According to the latest epidemiology of the US, B-cell cancers account for > 3% of all new cancer cases and > 80% of non-Hodgkin lymphomas. However, the disease-modifying small molecular drug suitable for most B-cell cancers is still lacking.
Baoyu Wu, Jingyu Li, Han Wang, Jianguo Liu, Jiayong Li, Fang Sun, Dong chuan Feng   +6 more
doaj   +1 more source

Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. [PDF]

, 2018
OBJECTIVE:Epigenetic modifications have previously been associated with rheumatoid arthritis (RA). In this study, we aimed to determine whether differential DNA methylation in peripheral blood cell subpopulations is associated with any of 4 clinical ...
Barcellos, Lisa F, Chernitskiy, Vladimir, Criswell, Lindsey A, Graf, Jonathan, Harrison, Ruby, Holingue, Calliope, Imboden, John, Link, Thomas, Mok, Amanda, Quach, Diana, Quach, Hong L, Rhead, Brooke, Shao, Xiaorong, Sinclair, Elizabeth   +13 more
core   +1 more source

A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis

Arthritis Research & Therapy, 2021
Background Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation through cell death and proinflammatory cytokine production.
Kathleen Weisel, Scott Berger, Katie Thorn, Peter C. Taylor, Charles Peterfy, Hilary Siddall, Debra Tompson, Susanne Wang, Emilia Quattrocchi, Susan W. Burriss, Jochen Walter, Paul Peter Tak   +11 more
doaj   +1 more source

Modulation of parathyroid hormone 1 receptor (PTH1R) signaling by receptor activity-modifying proteins (RAMPs)

, 2023
G Protein-gekoppelte Rezeptoren (GPCRs) bilden die größte und pharmakologisch wichtigste Familie von Zelloberflächenrezeptoren, die zahlreiche (patho-)physiologische Prozesse im menschlichen Körper steuern. GPCRs übertragen während des Rezeptoraktivierungsprozesses extrazelluläre Signale in das Zellinnere, wo durch die extrazelluläre Stimulation ...
openaire   +2 more sources

The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]

, 2017
Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna, J LiWang, Patricia, Jian, Mike, S Schill, Megan   +3 more
core   +2 more sources