Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins. [PDF]
J Biol Chem, 2023 Cholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled receptor (GPCR) Mas-related GPCR subtype X4 (MRGPRX4) has been identified as a receptor for bile acids, which are ...
Kotliar IB +9 more
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Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins. [PDF]
Pharmacol Rev, 2023 G protein-coupled receptors (GPCRs) are known to interact with several other classes of integral membrane proteins that modulate their biology and pharmacology.
Kotliar IB +4 more
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Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins [PDF]
iScience, 2019 Summary: A recent phylogenetic analysis showed global co-evolution of G protein-coupled receptors (GPCRs) and receptor-activity-modifying proteins (RAMPs) suggesting global interactions between these two protein families. Experimental validation of these
Shahar Barbash +5 more
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GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs. [PDF]
Proc Natl Acad Sci U S A, 2017 SignificanceG-protein–coupled receptors (GPCRs) are the largest group of membrane receptors in eukaryotes, are involved in a plethora of cellular processes, and are implicated in many human diseases. Several individual GPCRs were shown to interact with a small gene group called receptor activity-modifying proteins (RAMPs).
Barbash S +4 more
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Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles. [PDF]
Annu Rev Pharmacol Toxicol, 2016 It is now recognized that G protein–coupled receptors (GPCRs), once considered largely independent functional units, have a far more diverse molecular architecture. Receptor activity-modifying proteins (RAMPs) provide an important example of proteins that interact with GPCRs to modify their function.
Hay DL, Pioszak AA.
europepmc +5 more sources
Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties. [PDF]
J Biol Chem, 2016 Adrenomedullin (AM) is a peptide hormone with numerous effects in the vascular systems. AM signals through the AM1 and AM2 receptors formed by the obligate heterodimerization of a G protein-coupled receptor, the calcitonin receptor-like receptor (CLR ...
Watkins HA +18 more
europepmc +7 more sources
A selective role for receptor activity-modifying proteins in subchronic action of the amylin selective receptor agonist NN1213 compared with salmon calcitonin on body weight and food intake in male mice. [PDF]
Eur J Neurosci, 2021 The role of receptor activity‐modifying proteins (RAMPs) in modulating the pharmacological effects of an amylin receptor selective agonist (NN1213) or the dual amylin–calcitonin receptor agonist (DACRA), salmon calcitonin (sCT), was tested in three RAMP ...
Arrigoni S +6 more
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Calcitonin and amylin receptor peptide interaction mechanisms. INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS. [PDF]
J Biol Chem, 2016 Sang-Min Lee, Debbie L. Hay, and Augen A. Pioszak The rAmy(8 –37) Y37A and Y37P peptides used in this study were synthesized with an additional Tyr at their N termini to permit quantification by UV absorbance.
Lee SM, Hay DL, Pioszak AA.
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An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. [PDF]
Cell Discov, 2016 G protein-coupled receptors are allosteric proteins that control transmission of external signals to regulate cellular response. Although agonist binding promotes canonical G protein signalling transmitted through conformational changes, G protein ...
J Gingell J +7 more
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Novel Receptor Partners and Function of Receptor Activity-modifying Proteins* [PDF]
Journal of Biological Chemistry, 2003 The receptor activity-modifying proteins (RAMPs) comprise a family of three accessory proteins that heterodimerize with the calcitonin receptor-like receptor (CL receptor) or with the calcitonin receptor (CTR) to generate different receptor phenotypes ...
A. Christopoulos +8 more
semanticscholar +3 more sources