Results 281 to 290 of about 546,866 (330)

Expression of the calcitonin receptor, calcitonin receptor‐like receptor, and receptor activity modifying proteins during osteoclast differentiation

Journal of Cellular Biochemistry, 2008
AbstractThe expressions of the calcitonin receptor (CTR), the calcitonin receptor‐like receptor (CLR), the receptor activity‐modifying proteins (RAMP) 1–3, and of the receptor component protein (RCP) have been studied in mouse bone marrow macrophages (BMM) during osteoclast differentiation, induced by treatment with M‐CSF and RANKL.
S. Granholm, P. Lundberg, U. Lerner
semanticscholar   +3 more sources

Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries.

Neuroscience Letters, 1998
Recently a new type of proteins modulating the pharmacological profile of the calcitonin receptor-like receptor (CRLR) were identified. The receptor-activity-modifying proteins (RAMPs) were shown to be essential for the expression of a functional CRLR and furthermore the RAMPs seemed to modify ligand selectivity of CRLR: coexpression of CRLR and RAMP1 ...
A. Sams, I. Jansen-Olesen
semanticscholar   +3 more sources

Functional relevance of G-protein-coupled-receptor-associated proteins, exemplified by receptor-activity-modifying proteins (RAMPs).

Biochemical Society Transactions, 2001
The calcitonin (CT) receptor (CTR) and the CTR-like receptor (CRLR) are close relatives within the type II family of G-protein-coupled receptors, demonstrating sequence identity of 50%. Unlike the interaction between CT and CTR, receptors for the related hormones and neuropeptides amylin, CT-gene-related peptide (CGRP) and adrenomedullin (AM) require ...
J. Fischer, R. Muff, W. Born
semanticscholar   +3 more sources

Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS.

Peptides, 2023
Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition characterized by widespread inflammation and pulmonary edema. Adrenomedullin (AM), a bioactive peptide with various functions, is expected to be applied in treating ARDS. Its
T. Kasahara, Megumu Tanaka, Yunlu Zhao, Akiko Kamiyoshi, T. Sakurai, Yuka Ichikawa-Shindo, Hisaka Kawate, Yorishige Matsuda, Yan Zhang, Qianqian Guo, Peixuan Li, Ken Hoshiyama, Jiake Li, Naho Onishi, Marina Hayashi, Hideki Sanjo, Kumiko Ishida, Satoshi Tanaka, M. Kawamata, T. Shindo   +19 more
semanticscholar   +1 more source

Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes

Molecular Pharmacology, 2005
Calcitonin (CT) receptors dimerize with receptor activity-modifying proteins (RAMPs) to create high-affinity amylin (AMY) receptors, but there is no reliable means of pharmacologically distinguishing these receptors. We used agonists and antagonists to define their pharmacology, expressing the CT(a) receptor alone or with RAMPs in COS-7 cells and ...
Debbie L, Hay, George, Christopoulos, Arthur, Christopoulos, David R, Poyner, Patrick M, Sexton   +4 more
openaire   +2 more sources

The receptor activity modifying protein family of G protein coupled receptor accessory proteins

Seminars in Cell & Developmental Biology, 2004
Receptor diversity for the calcitonin peptide family is created by the interaction of two 7-transmembrane proteins--the calcitonin receptor (CTR) or the calcitonin receptor-like receptor (CL-R)--with the receptor activity modifying protein (RAMP) family.
Madhara, Udawela, Debbie L, Hay, Patrick M, Sexton   +2 more
openaire   +2 more sources

Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs)

2022
AbstractCholestatic itch is a severe and debilitating symptom in liver diseases with limited treatment options. The class A G protein-coupled receptor (GPCR) Mas-related GPCR subtype X4 (MRGPRX4) has been identified as a receptor for bile acids, which are potential cholestatic pruritogens.
Ilana B. Kotliar, Emilie Ceraudo, Kevin Kemelmakher-Liben, Deena A. Oren, Emily Lorenzen, Tea Dodig-Crnković, Mizuho Horioka-Duplix, Thomas Huber, Jochen M. Schwenk, Thomas P. Sakmar   +9 more
openaire   +1 more source

The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.

Molecular Pharmacology, 1999
The calcitonin receptor-like receptor (CRLR) can function as either a receptor for calcitonin gene-related peptide (CGRP) or for adrenomedullin (ADM), depending upon the coexpression of a novel family of single transmembrane proteins, which we have ...
Neil J. Fraser, A. Wise, Jason Brown, L. McLatchie, Martin J. Main, Steven M. Foord   +5 more
semanticscholar   +1 more source

Distinct Receptor Activity-Modifying Protein Domains Differentially Modulate Interaction with Calcitonin Receptors

Molecular Pharmacology, 2006
Calcitonin receptors (CTRs) dimerize with receptor activity-modifying proteins (RAMPs) to generate high-affinity amylin (AMY) receptors; however, the relative contribution of individual RAMP domains to the formation of AMY receptors is poorly understood.
Madhara, Udawela, George, Christopoulos, Nanda, Tilakaratne, Arthur, Christopoulos, Anthony, Albiston, Patrick M, Sexton   +5 more
openaire   +2 more sources

Calcitonin receptor-like receptor (CLR) influences posttranslational events of receptor activity-modifying proteins (RAMPs)

Biochemical and Biophysical Research Communications, 2012
Adrenomedullins (AM) form a multifunctional subfamily of the calcitonin gene-related peptide (CGRP) superfamily, the members of which exert their physiological roles through a 1:1 combination of calcitonin receptor-like receptors (CLRs) and receptor activity-modifying proteins (RAMPs).
Kakon, Nag, Naznin, Sultana, Shigehisa, Hirose   +2 more
openaire   +2 more sources