Results 21 to 30 of about 546,866 (330)

Structure-function relationships of the N-terminus of receptor activity-modifying proteins. [PDF]

Br J Pharmacol, 2010
Qi T, Hay DL.
europepmc   +2 more sources

Plasma Clearance of Intravenously Infused Adrenomedullin in Rats with Acute Renal Failure

Biomolecules, 2022
Plasma adrenomedullin concentrations are reportedly elevated in patients with renal failure; however, the underlying mechanism is unclear. In this study, we investigated the plasma clearance of synthetic human adrenomedullin (AM) in two models of rats ...
Hiroshi Hosoda, Tsutomu Nakamura, Fumiki Yoshihara   +2 more
doaj   +1 more source

Cellular Factors That Shape the Activity or Function of Nitric Oxide-Stimulated Soluble Guanylyl Cyclase

Cells, 2023
NO-stimulated guanylyl cyclase (SGC) is a hemoprotein that plays key roles in various physiological functions. SGC is a typical enzyme-linked receptor that combines the functions of a sensor for NO gas and cGMP generator.
Iraida Sharina, Emil Martin
doaj   +1 more source

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

Communications Biology, 2021
Clark et al. explore the ability of ligands to activate the calcitonin-like receptor (CLR) in primary endothelial cells, and the influence of co-expressed receptor-activity modifying proteins (RAMPs).
Ashley J. Clark, Niamh Mullooly, Dewi Safitri, Matthew Harris, Tessa de Vries, Antoinette MaassenVanDenBrink, David R. Poyner, Davide Gianni, Mark Wigglesworth, Graham Ladds   +9 more
doaj   +1 more source

Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.

ACS Pharmacology & Translational Science, 2020
Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) receptors are critically important for metabolism, vascular tone, and inflammatory response.
Yi-Lynn Liang, M. Belousoff, Madeleine M. Fletcher, Xin Zhang, M. Khoshouei, Giuseppe Deganutti, Cassandra Koole, S. Furness, L. Miller, D. Hay, A. Christopoulos, C. Reynolds, R. Danev, D. Wootten, P. Sexton   +14 more
semanticscholar   +1 more source

Pharmacological levels of withaferin A (Withania somnifera) trigger clinically relevant anticancer effects specific to triple negative breast cancer cells [PDF]

, 2014
Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based
A Albini, A Cock-Rada, A Grigoriadis, An Wouters, AP Mazar, B Castellana, B Grin, B Jayaprakasam, D Hanahan, D Sarrio, Dariusz Ratman, DG Johnson, DR Hurst, ER Hahm, Erik Fransen, F Pereira, F Zambelli, Filip Lardon, G Chiappetta, G Natoli, GK Smyth, Guy Van Camp, H Yu, Ilse M. Beck, J Chia, J Lee, J Lee, JB Mitchem, JH Nijwening, JJ Steffan, JT Thaiparambil, K Belguise, K Miyazaki, Karen Heyninck, Karolien De Bosscher, Katarzyna Szarc vel Szic, KD Brown, Ken Declerck, Ken Op de Beeck, L Dumartin, L Ma, LC Mishra, LP Blair, M Endo, M Kaileh, M Tian, Marc Bracke, MD Edmonds, MJ Duffy, MJ Dunning, MN Ndlovu, N Brunner, N Pouliot, N Widodo, O De Wever, P Chi, PH O'Donnell, PJ Boimel, R Nanda, R Santana-Davila, Rajeev Samant, S Mirza, S Ramadoss, S Subbaram, SC Smith, SD Stan, SD Stan, SL Floor, TW Rockway, W Vanden Berghe, Wim Vanden Berghe, WL Berry, WW Bhat, Y He, YJ Surh   +74 more
core   +6 more sources

Activity dependent dissociation of the Homer1 interactome

Scientific Reports, 2022
Neurons encode information by rapidly modifying synaptic protein complexes, which changes the strength of specific synaptic connections. Homer1 is abundantly expressed at glutamatergic synapses, and is known to alter its binding to metabotropic glutamate
Mason Stillman, Jonathan D. Lautz, Richard S. Johnson, Michael J. MacCoss, Stephen E. P. Smith   +4 more
doaj   +1 more source

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias

Frontiers in Physiology, 2022
Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists.
Abigail Pearce, Theo Redfern-Nichols, Matthew Harris, David R. Poyner, Mark Wigglesworth, Graham Ladds   +5 more
doaj   +1 more source

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2) [PDF]

Journal of Biological Chemistry, 2015
The glucagon and glucagon-like peptide-1 (GLP-1) receptors play important, opposing roles in regulating blood glucose levels. Consequently, these receptors have been identified as targets for novel diabetes treatments. However, drugs acting at the GLP-1 receptor, although having clinical efficacy, have been associated with severe adverse side-effects ...
Weston, C., Lu, J., Li, N., Barkan, K., Richards, G.O., Roberts, D.J., Skerry, T.M., Poyner, D., Pardamwar, M., Reynolds, C.A., Dowell, S.J., Willars, G.B., Ladds, G.   +12 more
openaire   +6 more sources

Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation [PDF]

, 1997
Most working proteins, including metabolic enzymes, transcription regulators, and membrane receptors, transporters, and ion channels, share the property of allosteric coupling. The term 'allosteric' means that these proteins mediate indirect interactions
Lester, Henry A., Li, Jun, Zagotta, William N.   +2 more
core   +1 more source