Results 291 to 300 of about 546,866 (330)

Receptor Activity Modifying Proteins and Their Potential as Drug Targets

2010
The receptor activity modifying proteins (RAMPs) are a family of membrane proteins that interact with some G protein-coupled receptors (GPCRs) to regulate their function. RAMPs can alter GPCR pharmacology and can regulate their signaling as well as trafficking to and from the cell surface. GPCRs have been successfully exploited as drug targets for many
Denise L, Wootten, John, Simms, Debbie L, Hay, Arthur, Christopoulos, Patrick M, Sexton   +4 more
openaire   +2 more sources

Functional characterization of two human receptor activity-modifying protein 3 variants

Peptides, 2010
Adrenomedullin (AM) and amylin are involved in angiogenesis/lymphangiogenesis and glucose homeostasis/food intake, respectively. They activate receptor activity-modifying protein (RAMP)/G protein-coupled receptor (GPCR) complexes. RAMP3 with the calcitonin receptor-like receptor (CLR) forms the AM(2) receptor, whereas when paired with the calcitonin ...
Richard J, Bailey, Joshua W I, Bradley, David R, Poyner, Dan L, Rathbone, Debbie L, Hay   +4 more
openaire   +2 more sources

Novel regulation of adrenomedullin receptor by PDGF: role of receptor activity modifying protein-3

American Journal of Physiology-Cell Physiology, 2002
Receptor activity modifying protein-3 (RAMP-3) has been shown to complex with the calcitonin receptor-like receptor, establishing a functional receptor for adrenomedullin (AM). AM exhibits potent antiproliferative and antimigratory effects on rat mesangial cells (RMCs).
Wojciech, Nowak, Narayanan, Parameswaran, Carolyn S, Hall, Nambi, Aiyar, Harvey V, Sparks, William S, Spielman   +5 more
openaire   +2 more sources

Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product

Molecular Pharmacology, 1999
Receptor activity-modifying proteins (RAMPs) are single-transmembrane proteins that transport the calcitonin receptor-like receptor (CRLR) to the cell surface. RAMP 1-transported CRLR is a calcitonin gene-related peptide (CGRP) receptor. RAMP 2- or RAMP 3-transported CRLR is an adrenomedullin receptor.
G, Christopoulos, K J, Perry, M, Morfis, N, Tilakaratne, Y, Gao, N J, Fraser, M J, Main, S M, Foord, P M, Sexton   +8 more
openaire   +2 more sources

Adrenomedullin, Chemokine Receptors, and Receptor Activity Modifying Proteins in Lymphangiogenesis

2015
Over the past decade, we have begun to appreciate that the lymphatic vascular system does more than simply return plasma back into the circulatory system and, in fact, contributes to a wide variety of normal and disease states. For this reason, much research has been devoted to understanding how lymphatic vessels form and function, with a particular ...
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023

exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

Breast Cancer Statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Hyuna Sung, Kimberly D Miller, Rebecca L Siegel   +2 more
exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly