Results 51 to 60 of about 546,866 (330)
Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice. [PDF]
PLoS ONE, 2012 Even protective ventilation may aggravate or induce lung failure, particularly in preinjured lungs. Thus, new adjuvant pharmacologic strategies are needed to minimize ventilator-induced lung injury (VILI).
Holger Christian Müller-Redetzky +9 more
doaj +1 more source
Regulation of tomato fruit ripening [PDF]
, 2009 Fruit ripening is a sophisticatedly orchestrated developmental process, unique to plants, that results in major physiological and metabolic changes, ultimately leading to fruit decay and seed dispersal.
Bouzayen, Mondher +4 more
core +2 more sources
Molecules, 2019 The interaction between androgen receptor (AR) and coactivator proteins plays a critical role in AR-mediated prostate cancer (PCa) cell growth, thus its inhibition is emerging as a promising strategy for PCa treatment. To develop potent inhibitors of the
Tae-Kyung Lee +4 more
doaj +1 more source
Intermedin attenuates LPS-induced inflammation in the rat testis. [PDF]
PLoS ONE, 2013 First reported as a vasoactive peptide in the cardiovascular system, intermedin (IMD), also known as adrenomedullin 2 (ADM2), is a hormone with multiple potent roles, including its antioxidant action on the pulmonary, central nervous, cardiovascular and ...
Lei Li +6 more
doaj +1 more source
The Effect of N-Terminal Cyclization on the Function of the HIV Entry Inhibitor 5P12-RANTES. [PDF]
, 2017 Despite effective treatment for those living with Human Immunodeficiency Virus (HIV), there are still two million new infections each year. Protein-based HIV entry inhibitors, being highly effective and specific, could be used to protect people from ...
F Nguyen, Anna +3 more
core +2 more sources
Targeting Toll-like Receptor (TLR) Pathways in Inflammatory Arthritis: Two Better Than One?
Biomolecules, 2021 Inflammatory arthritis is a cluster of diseases caused by unregulated activity of the immune system. The lost homeostasis is followed by the immune attack of one’s self, what damages healthy cells and tissues and leads to chronic inflammation of various ...
Sandra Santos-Sierra
doaj +1 more source
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]
, 2015 Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C +2 more
core +1 more source
RGS9‐2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models
EMBO Molecular Medicine, 2018 Dopamine D2 receptor signaling is central for striatal function and movement, while abnormal activity is associated with neurological disorders including the severe early‐onset DYT1 dystonia.
Paola Bonsi +16 more
doaj +1 more source
Adaptive response and enlargement of dynamic range [PDF]
, 2011 Many membrane channels and receptors exhibit adaptive, or desensitized, response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation.
A. Csik\'asz-Nagy +27 more
core +1 more source
Redundant mechanisms for regulation of midline crossing in Drosophila.
PLoS ONE, 2008 During development, all neurons have to decide on whether to cross the longitudinal midline to project on the contralateral side of the body. In vertebrates and invertebrates regulation of crossing is achieved by interfering with Robo signalling either ...
Giorgio F Gilestro
doaj +1 more source