Results 241 to 250 of about 4,238,851 (307)

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Impact of ASO conjugation and receptor binding affinity on intracellular transport of mono- and bispecific TfR- and CD98-Brainshuttle^TM variants. [PDF]

MAbs
Sela T, Wirth T, Sommer A, Larraillet V, Butzer J, Lohmann S, Wittmann P, Klein C, Knoetgen H, Villasenor R, Indlekofer A, Hofer K, Schumacher F, Niewöhner J.   +13 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Genomic characterization of Sabiá virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding. [PDF]

PLoS Negl Trop Dis
Claro IM, Manuli ER, da Silva CAM, Coletti TM, Lemey P, Nastri AC, Casadio LVB, Duarte-Neto AN, Quick J, Romano CM, Whittaker C, Hill SC, Prete CA, Candido DS, Moreira FRR, Ramundo MS, Valença IN, de Jesus JG, Sales FCS, Cunha MS, Guerra JM, Mendes-Correa MC, Tozetto-Mendoza TR, Fumagalli MJ, Ho YL, Simmonds P, Ng WM, Bowden TA, de Souza WM, Pybus OG, Levin AS, Loman N, Sabino EC, Faria NR.   +33 more
europepmc   +1 more source

Receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human. [PDF]

Emerg Microbes Infect
Kandeil A, Chopra P, Ray SD, Ghotekar BK, Ranadheera C, Jeevan T, Fabrizio T, Rubrum A, Boons GJ, Tompkins SM, Bastien N, Webby RJ.   +11 more
europepmc   +1 more source

A novel lipid-triggered allosteric site modulates LC3-LIR receptor binding activity

Gahlot D, Castin J, Mathur S, Das D, Kumar A, Arun A, Gain C, Sharma M, Pal RK, Jain N, Biswal BK, Singh R, Thukral L.   +12 more
europepmc   +1 more source

Correction: Met-enkephalin modulates the stress responses of plasma concentrations of corticosterone, delta opioid receptor binding, pro-enkephalin expression, and processing in chickens. [PDF]

Front Physiol
Pierzchała-Koziec K, Scanes CG, Jaszcza K.   +2 more
europepmc   +1 more source

The glycan shield of alphaherpesvirus glycoprotein B modulates host co-receptor binding

Krepel ST, Ianiski FR, Janssen BJ, Snijder J.   +3 more
europepmc   +1 more source

Convergent increases in serotonin 1B receptor binding following ketamine and electroconvulsive therapy: a multi-centre bayesian re-analysis of PET data. [PDF]

Mol Psychiatry
Matheson GJ, Lundberg J, Gärde M, Veldman ER, Tateno A, Ekman CJ, Arakawa R, Knudsen GM, Okubo Y, Ogden RT, Tiger M.   +10 more
europepmc   +1 more source

The role of receptor binding and immunity in SARS-CoV-2 fitness landscape: A modeling study. [PDF]

iScience
Ding Z, Yuan HY.
europepmc   +1 more source