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Characterization of CGRP Receptor Binding
Current Protocols in Pharmacology, 2004AbstractCGRP receptor binding may be measured using homogenates of cell membranes or intact cells. Here a microcentrifugation‐based assay is described that utilizes radioiodinated CGRP in displacement studies to determine the binding parameters for any ligand that interacts with CGRP receptors. A similar assay is described for binding to cultured cells.
Alex C, Conner +2 more
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The Receptor-Binding Sequence of Urokinase
1987uPA is the urokinase type of plasminogen activator that has been associated with cellular invasion and tissue involution. Specific uPA receptors have been recently described (1,2). The receptor-binding domain of uPA is located in the 17,000 dalton amino-terminal fragment (ATF) and it is completely independent of the catalytic domain.
Appella E +6 more
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On the receptor binding site of relaxins
International Journal of Peptide and Protein Research, 1988Relaxin plays a critical role in viviparity and has recently been implicated as a hormone of oviparity as well. In most mammals relaxin causes the widening of the birth canal during parturition and suppresses uterine motility during pregnancy. Relaxins isolated from several species have shown a great deal of sequence variability, and speculations ...
E E, Büllesbach, C, Schwabe
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Binding of insulin dimers to receptors
Biophysical Chemistry, 1985A synthesis of current views of the nature of the self-association of insulin in solution, of the identity of the amino acid residues in the insulin molecule constituting the receptor binding site, and of characteristics of the apparent 'negative cooperativity' of the binding leads to the seemingly contradictory conclusions that only the monomeric form
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Antigen-Binding Receptors on Lymphocytes
1974The concept that activation of immunocompetent cells by antigen depends upon the presence of specific antigen-binding receptors on the cell surface has been central to immunologic theory since it was originally proposed by Paul Ehrlich (1900). Direct evidence for the existence of such receptors has been amassed in recent years.
J M, Davie, W E, Paul
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Receptor-Binding Profiles of Neuroleptics
1985Dopamine-receptor blockade seems to be a prominent effect of neuroleptics. Blockade of other receptors might, however, contribute to the therapeutic effect. A series of neuroleptics have been tested for affinity to DA D-1 and D-2 receptors, serotonin receptors (S2), alpha-adrenoceptors (alpha 1), histamine receptors (H1), and muscarinic cholinergic ...
J, Hyttel +3 more
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Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
exaly
Receptor Binding and Complex Structures of Human ACE2 to Spike RBD From Omicron and Delta SARS-CoV-2
Cell, 2022Xin Zhao, George F. Gao, Chao Su
exaly