Results 251 to 260 of about 4,238,851 (307)
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Binding of the Ah receptor to receptor binding factors in chromatin
Biochemical Pharmacology, 1993Dioxin induces biological responses through interaction with a specific intracellular receptor, the Ah receptor, and the subsequent interaction of the Ah receptor with chromatin. We report the binding of the Ah receptor, partially purified from rabbit liver, to receptor binding factors in chromatin. Rabbit liver chromatin proteins (CP) were isolated by
R T, Dunn, T S, Ruh, M F, Ruh
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Receptor binding of asialoerythropoietin
Journal of Cellular Biochemistry, 1992AbstractThe interaction of 125I‐asialoeythropoietin (asialoepo) with receptors has been characterized both by binding assay and affinity cross‐linking. Purified spleen cells from mice infected with the anemia strain of Friend virus (FVA cells) have receptors for 123I‐asialoepo with two classes of affinity constant: one with Kd = 0.02–0.03 nM and 300 ...
Y J, Dong, C, Kung, E, Goldwasser
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Binding to Cysteinyl-Leukotriene Receptors
American Journal of Respiratory and Critical Care Medicine, 2000It is widely accepted that leukotrienes (LTs) exert their actions through high-affinity specific receptors, although only the LTB 4 receptor has been cloned so far (1). Given the differences between the two classes of LTs (LTB 4 versus LTC 4 , LTD 4 , and LTE 4 , i.e., cysteine-containing leukotrienes or cysteinyl-LTs) in terms of both structure and ...
S. Nicosia +3 more
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A ligand-receptor binding assay by receptor immobilization
Analytical Biochemistry, 1988Using transferrin-transferrin receptor binding as a model of ligand-receptor binding, we have developed a new and simple binding assay for the solubilized receptor. Solubilized membrane proteins containing transferrin receptor were immobilized by covalent binding to beads having chemical reactive epoxide groups, and then 125I-labeled transferrin was ...
M, Takami, I, Kasuya, H, Tsunoo
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2016
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be useful ...
Catani, VM, GASPERI, VALERIA
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Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be useful ...
Catani, VM, GASPERI, VALERIA
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Receptor Binding Thermodynamics at the Neuronal Nicotinic Receptor
Current Topics in Medicinal Chemistry, 2004Simple determination of K(A) or K(D) values makes it possible to calculate the standard free energy DeltaG degrees = -RTlnK(A) = RT lnK(D)(T= 298.15 K) of the binding equilibrium but not that of its two components as defined by the Gibbs equation DeltaG degrees = DeltaH degrees - TDeltaS degrees where DeltaH degrees and DeltaS degrees are the ...
BOREA, Pier Andrea +6 more
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2022
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both the central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be ...
Gasperi V, Savini I, Catani MV
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Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both the central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be ...
Gasperi V, Savini I, Catani MV
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Androgen and Antiandrogen Receptor Binding
Annual Review of Physiology, 1984Recent studies have demonstrated that androgenic stimulation of early and late responding genes depends on the nuclear uptake of the receptor-steroid complex. The longer the complex is retained in the nucleus, the shorter the lag period and the greater the magnitude of the response. Most antiandrogens or their metabolites bind to the cytosolic androgen
O A, Jänne, C W, Bardin
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Nuclear Medicine and Biology, 1994
The successful imaging of tumor biochemistry using a receptor binding radiotracer is related to the affinity constant and the receptor concentration. The target to nontarget ratio can be predicted by steady state equations using in vitro data, although this is a necessary but not sufficient upper limit.
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The successful imaging of tumor biochemistry using a receptor binding radiotracer is related to the affinity constant and the receptor concentration. The target to nontarget ratio can be predicted by steady state equations using in vitro data, although this is a necessary but not sufficient upper limit.
openaire +2 more sources