Results 121 to 130 of about 38,510 (295)

Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases

International Journal of Inflammation, 2013
The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE-ligands interaction induces a series of signal transduction cascades and lead to
Yaw Kuang Chuah, Rusliza Basir, Herni Talib, Tung Hing Tie, Norshariza Nordin   +4 more
doaj   +1 more source

Identification of pyridinoline, a collagen crosslink, as a novel intrinsic ligand for the receptor for advanced glycation end-products (RAGE)

, 2018
Advanced glycation end-products (AGEs) elicit inflammatory responses via the receptor for AGEs (RAGE) and participate in the pathogenesis of diabetic complications.
Toshiki Hasegawa, Fumitaka Hayase, Hirohito Watanabe, Takayuki Fujino, Teruyuki Usui, Yoto Murakami, Ryotaro Kurachi   +6 more
core   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Effect of protein glycation by methylglyoxal on pancreatic beta cell function [PDF]

Methylglyoxal is a physiological dicarbonyl metabolite and potent argininedirected glycating agent. It often modifies proteins at functional sites producing loss of positive charge, structural distortion and inactivation.
Tym, Amy
core  

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Glycation at the Crossroads of Disease Pathogenesis: Mechanistic Insights and Therapeutic Frontiers

Diseases
Protein glycation is a nonenzymatic modification that links sugar chemistry to molecular aging and chronic disease. Sequential reactions involving Schiff bases, Amadori products, and reactive α dicarbonyl intermediates generate advanced glycation end ...
Sneha Krishnamoorthi, Rupachandra Saravanakumar, Vivek Kumar   +2 more
doaj   +1 more source

Increased Expression of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease [PDF]

, 2014
金沢医科大学博士（医学 ...
451, タナカ マコト, 田中 良
core  

Receptor for advanced glycation end products (RAGE) in type 1 diabetes pathogenesis

, 2016
The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells ...
Leung, Sherman S., Forbes, Josephine M., Borg, Danielle J.   +2 more
core   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study.

, 2020
International audienceRe-epithelialization of the alveolar surface is a key process of lung alveolar epithelial barrier repair after acute lung injury.
Constantin, Jean-Michel, Pereira, Bruno, Sapin, Vincent, Zhai, Ruoyang, Henrioux, Fanny, Gross, Christelle, Blanchon, Loïc, Blondonnet, Raiko, Belville, Corinne, Ebrahimi, Ebrahim, Audard, Jules, Choltus, Helena, Jabaudon, Matthieu   +12 more
core   +1 more source