Results 101 to 110 of about 59,203 (302)

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

New Glycotoxin Inhibitor from Sesuvium sesuvioides Mitigates Symptoms of Insulin Resistance and Diabetes by Suppressing AGE-RAGE Axis in Skeletal Muscle

Molecules
The current study intended to investigate the role of new natural compounds derived from the Sesuvium sesuvioides plant in mitigating symptoms of diabetes and insulin resistance in the diabetic mice model.
Safina Ghaffar, Rizwana Sanaullah Waraich, Raha Orfali, Areej Al-Taweel, Hanan Y. Aati, Sonia Kamran, Shagufta Perveen   +6 more
doaj   +1 more source

Postprandial Glucose Spikes, an Important Contributor to Cardiovascular Disease in Diabetes?

Frontiers in Cardiovascular Medicine, 2020
Clinical trials investigating whether glucose lowering treatment reduces the risk of CVD in diabetes have thus far yielded mixed results. However, this doesn't rule out the possibility of hyperglycemia playing a major causal role in promoting CVD or ...
Nordin M. J. Hanssen, Nordin M. J. Hanssen, Michael J. Kraakman, Michelle C. Flynn, Prabhakara R. Nagareddy, Casper G. Schalkwijk, Andrew J. Murphy, Andrew J. Murphy   +7 more
doaj   +1 more source

Cardiac remodelling in the era of the recommended four pillars heart failure medical therapy

ESC Heart Failure, Volume 12, Issue 2, Page 1029-1044, April 2025.
Abstract Cardiac remodelling is a key determinant of worse cardiovascular outcome in patients with heart failure (HF) and reduced ejection fraction (HFrEF). It affects both the left ventricle (LV) structure and function as well as the left atrium (LA) and the right ventricle (RV).
Giada Colombo, Tor Biering‐Sorensen, Joao P. Ferreira, Carlo Mario Lombardi, Andrea Bonelli, Andrea Garascia, Marco Metra, Riccardo M. Inciardi   +7 more
wiley   +1 more source

RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB [PDF]

, 2005
The exquisite ability of the liver to regenerate is finite. Identification of mechanisms that limit regeneration after massive injury holds the key to expanding the limits of liver transplantation and salvaging livers and hosts overwhelmed by carcinoma ...
Cataldegirmen, Guellue, Zeng, Shan, Feirt, Nikki, Ippagunta, Nikalesh, Dun, Hao, Qu, Wu, Lu, Yan, Rong, Ling Ling, Hofmann, Marion A, Kislinger, Thomas, Pachydaki, Sophia I, Jenkins, Daniel G, Weinberg, Alan, Lefkowitch, Jay, Rogiers, Xavier, Yan, Shi Fang, Schmidt, Ann Marie, Emond, Jean C   +17 more
core   +1 more source

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, EarlyView.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source

The usefulness of soluble receptor for advanced glycation end-products in the identification of COPD frequent exacerbator phenotype

International Journal of COPD, 2018
Joanna Miłkowska-Dymanowska,1,2,* Adam J Białas,1,2,* Karolina Szewczyk,1 Zofia Kurmanowska,1 Paweł Górski,1,2 Wojciech J Piotrowski1,2 1Department of Pneumology and Allergy, Medical University of Łódź, Łódź, Poland; 2Healthy Ageing
Miłkowska-Dymanowska J, Białas AJ, Szewczyk K, Kurmanowska Z, Górski P, Piotrowski WJ   +5 more
doaj  

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source

Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. [PDF]

, 2019
Poor solute transport through the cartilage endplate (CEP) impairs disc nutrition and could be a key factor that limits the success of intradiscal biologic therapies.
Dolor, Aaron, Fields, Aaron J, Lazar, Ann A, Lotz, Jeffrey C, Sampson, Sara L, Szoka, Francis C   +5 more
core   +2 more sources

S100B is increased in Parkinson’s disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway [PDF]

, 2012
Peer reviewedPublisher ...
Berg, Daniela, Fleckenstein, Corinna, Itohara, Shigeyoshi, Lang, Johannes, Maetzler, Walter, Martin, Heather Louise, Mounsey, Ross Brian, Mustafa, Sarah, Sathe, Kinnari, Schulte, Claudia, Synofzik, Matthis, Teismann, Peter, Vukovic, Zvonimir   +12 more
core   +1 more source