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Activation of the receptor for advanced glycation end products and consequences on health
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2017Advanced glycation end products (AGE) resulted from a reaction between free amino group of proteins and carbohydrates. This reaction is followed by oxidation and molecular rearrangement. Alternatively AGEs can be produced by glycolysis and oxidation. AGEs bind to a cellular receptor RAGE.
Marie-Paule, Wautier +2 more
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Advanced Glycation End Product Receptor‐Mediated Cellular Dysfunction
Annals of the New York Academy of Sciences, 2005Abstract: Advanced glycation end products (AGEs), S100/calgranulins, and HMGB1 proteins supposedly play a pivotal role in diabetes mellitus and other chronic inflammatory diseases by promoting cellular dysfunction via binding to cellular surface receptors.
Angelika, Bierhaus +4 more
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Rage: A Novel Cellular Receptor for Advanced Glycation End Products
Diabetes, 1996Exposure of proteins to reducing sugars results in nonenzymatic glycation with the ultimate formation of advanced glycation end products (AGEs). One means through which AGEs modulate cellular functions is through binding to specific cell surface acceptor molecules.
A M, Schmidt +9 more
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Role of receptor for advanced glycation end products in cardiogenic shock*
Critical Care Medicine, 2012Activation of the receptor for advanced glycation end products by its ligands promotes inflammatory processes and tissue injury. The available evidence suggests that soluble forms of receptor for advanced glycation end products circulating in the plasma may neutralize the ligand-mediated damage by acting as a decoy.
Simina-Ramona, Selejan +5 more
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The role of the receptor for advanced glycation end-products in lung fibrosis
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007The pathogenesis of pulmonary fibrosis remains unclear. The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor known to be involved in the process of fibrotic change in several organs, such as peritoneal fibrosis and kidney fibrosis. The aim of this study was to examine the contribution of RAGE during the acute inflammation
Mei, He +6 more
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Receptor for advanced glycation end-product in ischemia-reperfusion injury
International ImmunopharmacologyIschemia-reperfusion injury (IRI) serves as a pivotal pathological mechanism underlying tissue damage in diverse clinical scenarios, particularly in organ transplantation, and cardiovascular surgery. A key factor in this process is the inflammatory response triggered by the receptor for advanced glycation end-products (RAGE).
Xi, Luo +3 more
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Nutrition Research, 2014
Advanced glycation end products (AGEs) not only inhibit DNA synthesis but also play a role in diabetic retinopathy by evoking apoptosis and inflammation in retinal pericytes via interaction with a receptor for AGE (RAGE). Similarly, sulforaphane, which is a naturally occurring isothiocyanate that is found in widely consumed cruciferous vegetables ...
Sayaka, Maeda +4 more
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Advanced glycation end products (AGEs) not only inhibit DNA synthesis but also play a role in diabetic retinopathy by evoking apoptosis and inflammation in retinal pericytes via interaction with a receptor for AGE (RAGE). Similarly, sulforaphane, which is a naturally occurring isothiocyanate that is found in widely consumed cruciferous vegetables ...
Sayaka, Maeda +4 more
openaire +2 more sources
American Journal of Respiratory and Critical Care Medicine, 2013
Sukkar, Maria B., Postma, Dirkje S.
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Sukkar, Maria B., Postma, Dirkje S.
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Advanced glycation end‐products and their receptors: Exercise effects
Obesity Reviews, 2020Kazuhiko Kotani, Alejandro Gugliucci
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