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SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL‐Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development

Aging Cell, Volume 25, Issue 5, May 2026.
Mechanistic study of AGEs‐induced OA progression via SIRT1/RANKL/RANK signaling‐mediated osteoclast–chondrocyte communication and cellular senescence. ABSTRACT Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology.
Yizhou Li, Jian Wu, Rui Liu, Qiang Li, Fei Xue   +4 more
wiley   +1 more source

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Advanced glycation end product ligands for the receptor for advanced glycation end products: biochemical characterization and formation kinetics

Analytical Biochemistry, 2004
Advanced glycation end products (AGEs) accumulate with age and at an accelerated rate in diabetes. AGEs bind cell-surface receptors including the receptor for advanced glycation end products (RAGE). The dependence of RAGE binding on specific biochemical characteristics of AGEs is currently unknown.
Jeroen DeGroot, Johan M Tekoppele, Thomas E Hughes   +2 more
exaly   +4 more sources

Modulation of Soluble Receptor for Advanced Glycation End Products Isoforms and Advanced Glycation End Products in Long-Living Individuals

Biomarkers in Medicine, 2021
Background: Circulating levels of soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) correlate with aging/cardiovascular risk, which is delayed in long-living individuals (LLIs). AGEs/sRAGE isoforms (cleaved RAGE [cRAGE] and secretory RAGE [esRAGE]) ratio is a valuable marker for disease risk ...
Francesco Scavello, Calogero C Tedesco, Stefania Castiglione, Anna Maciag, Elena Sangalli, Fabrizio Veglia, Gaia Spinetti, Annibale A Puca, Angela Raucci   +8 more
openaire   +2 more sources

Understanding RAGE, the receptor for advanced glycation end products

Journal of Molecular Medicine, 2005
Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-beta peptides, and the family of beta-sheet fibrils have been shown to contribute to a number of chronic diseases such as diabetes, amyloidoses, inflammatory conditions, and tumors by promoting cellular dysfunction via binding to cellular surface receptors.
Angelika, Bierhaus, Per M, Humpert, Michael, Morcos, Thoralf, Wendt, Triantafyllos, Chavakis, Bernd, Arnold, David M, Stern, Peter P, Nawroth   +7 more
openaire   +2 more sources

Receptor for advanced glycation end-products in neurodegenerative diseases

Reviews in the Neurosciences, 2015
AbstractThis review, for the first time, aims to summarize the current knowledge in the emerging field of RAGE (receptor for advanced glycation end-products) studies in neurodegeneration and neurodegenerative diseases. RAGE, a member of the multiligand cell surface immunoglobulin family, has been implicated in numerous pathological conditions – from ...
Judyta, Juranek, Rashmi, Ray, Marta, Banach, Vivek, Rai   +3 more
openaire   +2 more sources

Expression of advanced glycation end‐product receptors in the cochlea

The Laryngoscope, 2010
AbstractObjectives/Hypothesis:Advanced glycation end products (AGE) have recently been implicated in aging changes within different tissues of the body. The role of AGEs and their receptors in the mammalian inner ear is largely unknown. In this study we analyzed for the expression of two AGE receptors, namely RAGE and Ddost (AGE‐R1).Study Design ...
Hanusek, Claudia, Setz, Cristian, Radojevic, Vesna, Brand, Yves, Levano, Soledad, Bodmer, Daniel   +5 more
openaire   +3 more sources

Receptor for Advanced Glycation End Products: Dementia and Cognitive Impairment

Drug Research, 2023
AbstractThe pathophysiological processes of dementia and cognitive impairment are linked to advanced glycation end products (AGEs) and their receptor (RAGE).The neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau protein and senile plaques (SPs), which are brought on by ...
Aditya, Singh, Vaseem Ahamad, Ansari, Tarique, Mahmood, Farogh, Ahsan, Rufaida, Wasim, Mohammad, Shariq, Saba, Parveen, Shubhrat, Maheshwari   +7 more
openaire   +2 more sources

Scavenger Receptors that Recognize Advanced Glycation End Products

Trends in Cardiovascular Medicine, 2002
Scavenger receptors recognize modified low-density lipoproteins (LDLs) such as acetylated LDL and oxidized LDL. Advanced glycation end products (AGE), which are generated through long-term exposure of proteins to glucose, also behave as active ligands for some scavenger receptors, including class A scavenger receptor (SR-A) and class B scavenger ...
Akira, Miyazaki, Hitoshi, Nakayama, Seikoh, Horiuchi   +2 more
openaire   +2 more sources

Advanced glycation end products, their receptors and diabetic angiopathy

Journal of the Peripheral Nervous System, 2002
The role of chronic hyperglycemia in the development of diabetic microvascular complications and in neuropathy has been clearly established by intervention studies. However, the biochemical or cellular links between elevated blood glucose levels, and the vascular lesions remain incompletely understood.
J L, Wautier, P J, Guillausseau
openaire   +2 more sources

Receptor for advanced glycation end products in bacterial infection

Current Opinion in Infectious Diseases, 2012
Sepsis is still associated with excess morbidity and mortality worldwide, despite significant advances in critical care medicine. A novel approach is needed in the treatment of sepsis, one that will aim to correct the specific immunologic imbalance that is detrimental to the septic host.As receptor for advanced glycation end products (RAGE) is involved
Christaki, Eirini, Lazaridis, Nikolaos, Opal, Steven M., Christaki, Eirini, Lazaridis, Nikolaos, Opal, Steven M.   +5 more
openaire   +3 more sources