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Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes

Medicinal Research Reviews, 2020
Type 1 diabetes (T1D) is one of the most common chronic diseases manifesting in early life, with the prevalence increasing worldwide at a rate of approximately 3% per annum.
Amelia Fotheringham, Josephine Forbes, Selena le Bagge   +2 more
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Scavenger Receptors that Recognize Advanced Glycation End Products

Trends in Cardiovascular Medicine, 2002
Scavenger receptors recognize modified low-density lipoproteins (LDLs) such as acetylated LDL and oxidized LDL. Advanced glycation end products (AGE), which are generated through long-term exposure of proteins to glucose, also behave as active ligands for some scavenger receptors, including class A scavenger receptor (SR-A) and class B scavenger ...
Akira, Miyazaki, Hitoshi, Nakayama, Seikoh, Horiuchi   +2 more
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Receptor for Advanced Glycation End Products: Dementia and Cognitive Impairment

Drug Research, 2023
AbstractThe pathophysiological processes of dementia and cognitive impairment are linked to advanced glycation end products (AGEs) and their receptor (RAGE).The neurofibrillary tangles (NFTs) of abnormally hyperphosphorylated tau protein and senile plaques (SPs), which are brought on by ...
Aditya, Singh, Vaseem Ahamad, Ansari, Tarique, Mahmood, Farogh, Ahsan, Rufaida, Wasim, Mohammad, Shariq, Saba, Parveen, Shubhrat, Maheshwari   +7 more
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Advanced glycation end products, their receptors and diabetic angiopathy

Journal of the Peripheral Nervous System, 2002
The role of chronic hyperglycemia in the development of diabetic microvascular complications and in neuropathy has been clearly established by intervention studies. However, the biochemical or cellular links between elevated blood glucose levels, and the vascular lesions remain incompletely understood.
J L, Wautier, P J, Guillausseau
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Receptor for advanced glycation end products in bacterial infection

Current Opinion in Infectious Diseases, 2012
Sepsis is still associated with excess morbidity and mortality worldwide, despite significant advances in critical care medicine. A novel approach is needed in the treatment of sepsis, one that will aim to correct the specific immunologic imbalance that is detrimental to the septic host.As receptor for advanced glycation end products (RAGE) is involved
Christaki, Eirini, Lazaridis, Nikolaos, Opal, Steven M., Christaki, Eirini, Lazaridis, Nikolaos, Opal, Steven M.   +5 more
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Expression of Receptor for Advanced Glycation End Products in Sarcoid Granulomas

American Journal of Respiratory and Critical Care Medicine, 2007
Abstract Rationale The receptor for advanced glycation end products (RAGE) engages a number of ligands implicated in inflammatory processes. The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis.
CAMPO I, MORBINI P, ZORZETTO M, TINELLI C, BRUNETTA E, VILLA C, BOMBIERI C, CUCCIA M, AGOSTINI, CARLO, BOZZI V, FACOETTI A, FERRAROTTI I, MAZZOLA P, SCABINI R, SEMENZATO, GIANPIETRO CARLO, PIGNATTI PF, POZZI E, LUISETTI M.   +17 more
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Role of receptor for advanced glycation end-products in pathogenesis of psoriasis

Molecular Biology, 2013
This review summarizes the existing knowledge regarding the role of receptor for advanced glycation end products which is a key participant of the inflammatory process, in pathogenesis of psoriasis. By interacting with multiple ligands and activating several signaling mechanisms, receptor for advanced glycation end products regulates gene expression ...
A G, Soboleva, S A, Bruskin, A A, Nikolaev, V V, Sobolev, A V, Mezentsev   +4 more
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Cellular signalling of the receptor for advanced glycation end products (RAGE)

Cellular Signalling, 2013
The receptor for advanced glycation end-product (RAGE) is the signal transduction receptor which senses a variety of signalling molecules including advanced glycation end products (AGEs), HMGB1, S100/calgranulins, β-amyloid, phosphatidylserine, C3a and advanced oxidation protein products (AOPPs).
Jianling, Xie, José D, Méndez, Verna, Méndez-Valenzuela, María Montserrat, Aguilar-Hernández   +3 more
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The receptor for advanced glycation end products: A fuel to pancreatic cancer

Seminars in Cancer Biology, 2018
The receptor for advanced glycation end products (RAGEs) was first illustrated in the year 1992. RAGE is a single-transmembrane and multi-ligand component of the immunoglobulin protein super family. The engagement of RAGE turns out to an establishment of numerous intracellular signalling mechanisms resulting in the progression and perpetuation of many ...
Uzma, Shahab, Mohd Kaleem, Ahmad, Abbas Ali, Mahdi, Mohd, Waseem, Binish, Arif, , Moinuddin, Saheem, Ahmad   +6 more
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Receptor for advanced glycation end products (RAGE) in atrial fibrillation

International Journal of Cardiology, 2013
with advanced heart failure. J Am Coll Cardiol 2006;48:2485–9. [9] Okonko DO, Grzeslo A, Witkowski T, et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency: FERRIC-HF: a randomized, controlled, observerblinded trial. JACC 2008;51:103.
Nitin, Mahajan, Veena, Dhawan
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