Results 251 to 260 of about 59,203 (302)
JCC Plus, Volume 1, Issue 3, May 2026.ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin +7 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Djordje S. Popovic +2 more
wiley +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases
MedComm, Volume 7, Issue 5, May 2026.1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang +6 more
wiley +1 more source
Association of four differently processed diets with plasma and urine advanced glycation end products and serum soluble receptor for advanced glycation end products concentration in healthy dogs. [PDF]
J Anim Physiol Anim Nutr (Berl)Bridglalsingh S +6 more
europepmc +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley +1 more source
Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.The effects of psyllium husk supplementation on metabolic regulators, insulin resistance markers, and SIRT6 expression in the liver and skeletal muscle tissues of type 2 diabetic rats were investigated. PHP demonstration has significant beneficial effects by partially improving metabolic dysfunctions and increasing antioxidant capacity in T2DM ...
Furkan Ümit +5 more
wiley +1 more source
A first structural model for covalent dimerization of S100 proteins
Acta Crystallographica Section F, Volume 82, Issue 5, Page 176-183, May 2026.The first molecular description of a disulfide‐crosslinked S100 homodimer is revealed by the crystallographic structure of an S100A6 variant bound to the receptor for advanced glycation end‐products (RAGE). Sequence‐conservation analyses and computational modeling suggest that this covalent architecture may be adopted by other S100 proteins, thus ...
Maria Demou, Laure Yatime
wiley +1 more source
Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging
Aging Cell, Volume 25, Issue 5, May 2026.This study shows that long‐term, but not short‐term, stress exposure triggers molecular changes in yeast that mirror established hallmarks of aging, including altered proteostasis, epigenetic shifts, and reduced lifespan. These changes are reversible upon stress removal, and the genes involved are conserved across all domains of life. ABSTRACT Aging is
Yanzhuo Kong +7 more
wiley +1 more source
A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]
, 2017 et al,, Yee, Derek
core +1 more source