Results 1 to 10 of about 403,129 (325)
Non-receptor protein tyrosine kinases.
Frontiers in Bioscience, 2003 The protein tyrosine kinases (PTKs) are enzymes catalyzing the transfer of the gamma-phosphate group of ATP to the hydroxyl groups of specific tyrosine residues in peptides. Although phosphotransfer reactions catalyzed by various PTKs are similar with regard to their basic mechanisms, their biological functions demonstrate a considerable degree of ...
A. Tsygankov
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Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment. [PDF]
Journal of Biochemistry, 2012 It is widely accepted that receptor protein-tyrosine kinases (RTKs) are activated upon dimerization by binding to their extracellular ligands. However, EGF receptor (EGFR) dimerization per se does not require ligand binding. Instead, its cytoplasmic kinase domains have to form characteristic head-to-tail asymmetric dimers to become active, where one ...
Y. Yamanashi +2 more
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Receptor protein tyrosine kinases and phosphatases.
Cold Spring Harbor Symposia on Quantitative Biology, 1992 It is clear that the number of receptor PTKs and PTPs encoded by a typical vertebrate genome is rather large. Although the signal pathways activated by the receptor PTKs may in many cases be common, specificity is provided by the ligand-binding domain and the availability of ligand.
T. Hunter +4 more
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Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase (*) [PDF]
Journal of Biological Chemistry, 1995 B61 was originally described as a novel secreted tumor necrosis factor-α-inducible gene product in endothelial cells (Holzman, L. B., Marks, R. M., and Dixit, V. M.(1990) Mol. Cell. Biol. 10, 5830-5838).
H. Shao +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 1992 K. Burgess +3 more
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The dictyostelium kinome--analysis of the protein kinases from a simple model organism. [PDF]
PLoS Genetics, 2006 Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced ...
Jonathan M Goldberg +6 more
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Biomolecules, 2021 Protein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases.
Raju V. S. Rajala +4 more
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Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation
Frontiers in Synaptic Neuroscience, 2022 Membrane lipid rafts are sphingolipids and cholesterol-enriched membrane microdomains, which form a center for the interaction or assembly of palmitoylated signaling molecules, including Src family non-receptor type protein tyrosine kinases.
Takashi Hayashi, Takashi Hayashi
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The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]
PLoS ONE, 2012 BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
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Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.
Proceedings of the National Academy of Sciences of the United States of America, 1995 Brian D. Bennetf +6 more
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