Results 1 to 10 of about 514,942 (384)

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI [PDF]

Cancer Cell International
Triple-Negative Breast Cancer (TNBC) is the most aggressive type of breast malignancy, with chemotherapy as the only mainstay treatment. TNBC patients have the worst prognoses as a large fraction of them do not achieve complete pathological response post-
Nazia Chaudhary, Bhagya Shree Choudhary, Anusha Shivashankar, Subhakankha Manna, Khyati Ved, Shagufa Shaikh, Sonal Khanna, Jeetnet Baar, Jagruti Dani, Sarthak Sahoo, R. Soundharya, Mohit Kumar Jolly, Nandini Verma   +12 more
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The dictyostelium kinome--analysis of the protein kinases from a simple model organism. [PDF]

PLoS Genetics, 2006
Dictyostelium discoideum is a widely studied model organism with both unicellular and multicellular forms in its developmental cycle. The Dictyostelium genome encodes 285 predicted protein kinases, similar to the count of the much more advanced ...
Jonathan M Goldberg, Gerard Manning, Allen Liu, Petra Fey, Karen E Pilcher, Yanji Xu, Janet L Smith   +6 more
doaj   +2 more sources

Regulation of Phosphoinositide Levels in the Retina by Protein Tyrosine Phosphatase 1B and Growth Factor Receptor-Bound Protein 14

Biomolecules, 2021
Protein tyrosine kinases and protein phosphatases play a critical role in cellular regulation. The length of a cellular response depends on the interplay between activating protein kinases and deactivating protein phosphatases.
Raju V. S. Rajala, Austin McCauley, Rahul Rajala, Kenneth Teel, Ammaji Rajala   +4 more
doaj   +1 more source

The Oncogenic Signaling Disruptor, NDRG1: Molecular and Cellular Mechanisms of Activity

Cells, 2021
NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers, including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in the inhibition of multiple tyrosine kinases, including EGFR, c-Met, HER2 and ...
Jason Chekmarev, Mahan Gholam Azad, Des R. Richardson   +2 more
doaj   +1 more source

The Jak/STAT signaling pathway is downregulated at febrile temperatures. [PDF]

PLoS ONE, 2012
BACKGROUND: The Janus family of kinases (JAKs), Jak1, Jak2, Jak3, and Tyk2, constitute a subgroup of non-receptor protein tyrosine kinases. Upon cytokine binding, the receptor-associated kinases are activated and phosphorylate tyrosine residues in their ...
Tobias Nespital, Ger J Strous
doaj   +1 more source

Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation

Frontiers in Synaptic Neuroscience, 2022
Membrane lipid rafts are sphingolipids and cholesterol-enriched membrane microdomains, which form a center for the interaction or assembly of palmitoylated signaling molecules, including Src family non-receptor type protein tyrosine kinases.
Takashi Hayashi, Takashi Hayashi
doaj   +1 more source

Targeting Canonical and Non-Canonical STAT Signaling Pathways in Renal Diseases

Cells, 2021
Signal transducer and activator of transcription (STAT) plays an essential role in the inflammatory reaction and immune response of numerous renal diseases.
Lili Gai, Yuting Zhu, Chun Zhang, Xianfang Meng   +3 more
doaj   +1 more source

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1

Cells, 2023
The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs.
Yagmur Kan, YiTing Paung, Markus A. Seeliger, W. Todd Miller   +3 more
doaj   +1 more source

Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future

Frontiers in Pharmacology, 2023
Tyrosine-protein phosphatase non-receptor type 2(PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases. Accumulating
Xiao-Er Tang, Ya-Qiong Cheng, Chao-Ke Tang   +2 more
doaj   +1 more source

Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts. [PDF]

PLoS Computational Biology, 2015
Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment.
Juan Palacios-Moreno, Lauren Foltz, Ailan Guo, Matthew P Stokes, Emily D Kuehn, Lynn George, Michael Comb, Mark L Grimes   +7 more
doaj   +1 more source