Results 191 to 200 of about 156,578 (338)

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu, Zicheng Yu, Yueping Liu, Lei Guo, Lianghong Teng, Lingchuan Guo, Li Liang, Jing Wang, Jie Gao, Ruiyu Li, Ling Yang, Xiu Nie, Dan Su, Zhiyong Liang   +13 more
wiley   +1 more source

Properties of FDA-approved small molecule protein kinase inhibitors: A 2024 update

Pharmacological Research
Owing to the dysregulation of protein kinase activity in many diseases including cancer, this enzyme family has become one of the most important drug targets in the 21st century.
Robert Roskoski, Jr.
doaj  

Regulation of Synaptic NMDA Receptor Activity by Post-Translational Modifications. [PDF]

Neurochem Res
Tahiri E, Corti E, Duarte CB.
europepmc   +1 more source

A potent protein‐tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor‐expressing tumor cells in vitro and in vivo. Int. J. Cancer, 76, 154–163 (1998) [PDF]

, 1999
N. Lydon, H. Mett, M. Mueller, M. Becker, R.M. Cozens, D. Daniels, P. Traxler, E. Buchdunger, D. Stover   +8 more
openalex   +1 more source

π‐PhenoDrug: A Comprehensive Deep Learning‐Based Pipeline for Phenotypic Drug Screening in High‐Content Analysis

Advanced Intelligent Systems, EarlyView.
This study develops a deep learning‐based pipeline named π‐PhenoDrug for cell phenotype‐driven drug activity screening. π‐PhenoDrug integrates cell segmentation, morphological profile construction, and phenotype analysis modules, and it can assess drug effects on living cells in both supervised and unsupervised modes.
Xiao Li, Qinxue Ouyang, Mingfei Han, Xiaoqing Liu, Fuchu He, Yunping Zhu, Ling Leng, Jie Ma   +7 more
wiley   +1 more source

Site-Specific Competitive Kinase Inhibitor Target Profiling Using Phosphonate Affinity Tags. [PDF]

Mol Cell Proteomics
van Bergen W, Nederstigt AE, Heck AJR, Baggelaar MP.   +3 more
europepmc   +1 more source

Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

, 1995
Betsy D. Bennett, FC Zeigler, Qiongnan Gu, B M Fendly, Audrey D. Goddard, Nancy A. Gillett, William Matthews   +6 more
openalex   +1 more source

Association of the High-Affinity Receptor for IgG with the Protein Tyrosine Kinases Hck and Lyn [PDF]

, 1995
Amu Wang, Paul Scholl, Raif S. Geha
openalex   +1 more source

Advances in Protein Kinase Regulation of Stress Responses in Fruits and Vegetables. [PDF]

Int J Mol Sci
Song Y, Li F, Ali M, Li X, Zhang X, Ahmed ZFR.   +5 more
europepmc   +1 more source

Identification of an Atypical Grb2 Carboxyl-terminal SH3 Domain Binding Site in Gab Docking Proteins Reveals Grb2-dependent and -independent Recruitment of Gab1 to Receptor Tyrosine Kinases [PDF]

, 2000
Lisa Lock, Isabelle Royal, Monica A. Naujokas, Morag Park   +3 more
openalex   +1 more source