Results 201 to 210 of about 156,578 (338)

syk protein tyrosine kinase regulates Fc receptor gamma -chain-mediated transport to lysosomes

, 1998
Christian Bonnerot
openalex   +2 more sources

Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation [PDF]

, 2000
Liyu Zeng, Perminder S. Sachdev, LunBiao Yan, Joseph L.‐K. Chan, Thomas Trenkle, Michael McClelland, John Welsh, Lu‐Hai Wang   +7 more
openalex   +1 more source

TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Sometimes Small Is Beautiful: Discovery of the Janus Kinases (JAK) and Signal Transducer and Activator of Transcription (STAT) Pathways and the Initial Development of JAK Inhibitors for IBD Treatment. [PDF]

Dig Dis Sci
Kaunitz JD.
europepmc   +1 more source

Regulation of T-Cell Antigen Receptor Signalling by Syk Tyrosine Protein Kinase

, 1997
Sylvain Latour, Marielle Fournel, André Veillette   +2 more
openalex   +1 more source

Direct Binding of the Signaling Adapter Protein Grb2 to the Activation Loop Tyrosines on the Nerve Growth Factor Receptor Tyrosine Kinase, TrkA [PDF]

, 2000
James I. MacDonald, Ela A. Gryz, Chris J. Kubu, Joseph M. Verdi, Susan O. Meakin   +4 more
openalex   +1 more source

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, EarlyView.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Tracking protein kinase targeting advances: integrating QSAR into machine learning for kinase-targeted drug discovery. [PDF]

Future Sci OA
Shahin R, Jaafreh S, Azzam Y.
europepmc   +1 more source

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

, 1996
Bin Li, Marianne Subleski, Noemi Fusaki, Tadashi Yamamoto, T D Copeland, G L Princler, Hsiang‐Fu Kung, Tohru Kamata   +7 more
openalex   +1 more source

Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte development [PDF]

, 2000
Jennifer Buckland, Daniel J. Pennington, Ludovica Bruno, Michael J. Owen   +3 more
openalex   +1 more source