Results 221 to 230 of about 181,056 (261)

B61 is a ligand for the ECK receptor protein-tyrosine kinase

Nature, 1994
A protein ligand for the ECK receptor protein-tyrosine kinase has been isolated by using the extracellular domain (ECK-X) of the receptor as an affinity reagent. Initially, concentrated cell culture supernatants were screened for receptor binding activity using immobilized ECK-X in a surface plasmon resonance detection system.
Timothy D. Bartley, Robert W. Hunt, Andrew A. Welcher, William J. Boyle, Vann P. Parker, Richard A. Lindberg, Hsieng S. Lu, Anne M. Colombero, Robin L. Elliott, Brenda A. Guthrie, Paige L. Holst, James D. Skrine, Robert J. Toso, Ming Zhang, Elsa Fernandez, Geraldine Trail, Brian Varnum, Yosef Yarden, Tony Hunter, Gary M. Fox   +19 more
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Comparative characterization of receptor and non-receptor associated protein tyrosine kinases

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1989
By using poly(Glu: Tyr, 4:1) as an exogenous substrate, the characteristics of insulin receptor associated protein tyrosine kinase (PTK) from rabbit skeletal muscle has been compared with a growth factor-independent non-receptor PTK partially purified from rat lung particulate fraction.
A K, Srivastava, J L, Chiasson
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The ErbB/HER receptor protein-tyrosine kinases and cancer

Biochemical and Biophysical Research Communications, 2004
The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor, consist of a growth-factor-binding ectodomain, a single transmembrane segment, an intracellular protein-tyrosine kinase catalytic domain, and a tyrosine-containing cytoplasmic tail.
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Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases

1994
Maintenance of a satisfactory immune system requires the daily generation of millions of lymphocytes from immature progenitor cells that reside (in adult mammals) in the bone marrow. Three fundamental processes underlie lymphopoiesis. First, a small population of hematopoietic stem cells (estimated to represent something less than 0.1% of bone marrow ...
R M, Perlmutter, S J, Anderson
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Signalling pathways operated by receptor protein tyrosine kinases

2002
The first RTK discovered was the EGFR. It was also the first receptor that provided evidence for a relationship between activating mutations (oncogenes) and cancer. About 90 genes code for protein tyrosine kinases in the human genome, out of which 58 are receptors (rPTK) and are classified into 20 subfamilies.
Bastien D. Gomperts, IJsbrand M. Kramer, Peter E.R. Tatham   +2 more
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VEGF receptor protein–tyrosine kinases: Structure and regulation

Biochemical and Biophysical Research Communications, 2008
The human VEGF family consists of VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF). The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2).
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Non-Receptor Protein Tyrosine Kinases and Phosphatases in Human Platelets

Thrombosis and Haemostasis, 1996
There is now a large and rapidly growing body of information on the different types of non-receptor tyrosine kinases and phosphatases present within platelets. These enzymes appear to play a critical role in co-ordinating, integrating and amplifying signals from multiple cell surface receptors.
S P, Jackson, S M, Schoenwaelder, Y, Yuan, H H, Salem, P, Cooray   +4 more
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Phosphorylation of the Nicotinic Acetylcholine Receptor by Protein Tyrosine Kinases^a

Annals of the New York Academy of Sciences, 1995
Most neurotransmitter receptors examined to date are either regulated by phosphorylation or contain consensus sequences for phosphorylation by protein kinases. The nicotinic acetylcholine receptor (AChR), which mediates depolarization at the neuromuscular junction, has served as a model for the study of the structure, function, and regulation of ligand-
S L, Swope, Z, Qu, R L, Huganir
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Non-receptor protein tyrosine kinases as immune targets of viruses

Immunology Today, 1997
Abstract Non-receptor protein tyrosine kinases (NRPTKs) are critically involved in signaling pathways that modulate growth, differentiation and (mature) cell function. Here, Yves Collette and Daniel Olive reviaw the recently identified interactions of virus proteins from Herpesviridae, Retroviridae and Papavaviridae with NRPTKs, mid propose that these
Y, Collette, D, Olive
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Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

Trends in Cell Biology, 2001
Signaling through receptor tyrosine kinases (RTKs) is a major mechanism for intercellular communication during development and in the adult organism, as well as in disease-associated processes. The phosphorylation status and signaling activity of RTKs is determined not only by the kinase activity of the RTK but also by the activities of protein ...
A, Ostman, F D, Böhmer
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