Results 241 to 250 of about 293,862 (300)

The Role of Protein Kinases in the Management of Oncological Diseases by Acting on Ferroptotic Pathways. [PDF]

Int J Mol Sci
Folgiero V, Caforio M.
europepmc   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Antibody-Drug Conjugates Targeting Resistance-Associated Signaling Pathways: Recent Advances and Future Perspectives. [PDF]

Int J Mol Sci
Xie D, Yang C, Gao S, Li J, Yang J, Li X, Jiang R, Cao F, Zhang S, Wang L, Sun M.   +10 more
europepmc   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Protein Tyrosine Phosphatases in Schizophrenia: A Review of Pathophysiology and Emerging Evidence. [PDF]

Cureus
Murugesan K, Rebellow D, Kasagga A, Mon AM, Anwar S.   +4 more
europepmc   +1 more source

Proteome-Wide Analysis of Functional Phosphosites in the FGFR Family of Proteins: Insights from Large-Scale Phosphoproteomic Analysis. [PDF]

Proteomes
Palollathil A, Mahin A, Perunelly Gopalakrishnan A, Poojari TR, Sambreena A, Basthikoppa Shivamurthy P, Raju R.   +6 more
europepmc   +1 more source

Post-translational Modifications in Proteins: Prediction Methods, Biological Functions, and Diseases. [PDF]

MedComm (2020)
Zhang S, Li J, Chen M, Huang H.
europepmc   +1 more source

Lipids regulate epidermal growth factor receptor activation by its ligands. [PDF]

Biochem Soc Trans
Hutchison JM, Lemmon MA.
europepmc   +1 more source

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Protein tyrosine kinases in the initiation of antigen receptor signaling

Current Opinion in Immunology, 1995
Intracellular responses to antigen receptor engagement involve the activation of protein tyrosine kinases and the tyrosine phosphorylation of cellular proteins, including components of the antigen receptor. Phosphorylation of two tyrosine residues within an 18 amino acid segment of the cytoplasmic domain of antigen receptor subunits, and the subsequent
Joseph Bolen, Joseph B Bolen
exaly   +3 more sources