Results 231 to 240 of about 181,056 (261)

Vertebrate non‐receptor protein–tyrosine kinase families

Genes to Cells, 1996
Many non‐receptor protein–tyrosine kinases (PTKs) function as subunits of receptors, either receptors with or without intrinsic PTK catalytic activity of their own. There are currently at least 33 known vertebrate genes that encode non‐receptor PTKs.
K, Neet, T, Hunter
openaire   +2 more sources

Protein tyrosine kinases couple the interleukin‐2 receptor to p21^ras

European Journal of Immunology, 1993
AbstractThe T cell growth factor interleukin‐2 (IL‐2) induces p21ras activation in T lymphocytes. We have previously shown that a protein kinase C (PKC)‐mediated pathway for p21ras regulation exists in T cells and that the IL‐2 receptor (IL‐2R) can couple to p21ras independently of the presence of the PKC pathway for p21ras regulation.
Izquierdo, Manuel, Cantrell, Doreen A.
openaire   +4 more sources

Salicylanilides as Inhibitors of the Protein Tyrosine Kinase Epidermal Growth Factor Receptor.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Liechti C, Séquin U, Bold G, Furet P, Meyer T, Traxler P   +5 more
openaire   +3 more sources

Separation of the protein-tyrosine kinase and phosphatidylinositol kinase activities of the human placental insulin receptor

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1988
On immunoprecipitation using a specific antiphosphotyrosine antibody, phosphatidylinositol kinase (EC 2.7.1.67) activity was separated from the protein-tyrosine kinase (EC 2.7.1.112) activity of the wheat germ agglutinin (WGA) -purified insulin receptor from human placenta.
J M, Carroscosa, E, Schleicher, R, Maier, C, Hackenberg, O H, Wieland   +4 more
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Protein tyrosine kinase receptors.

Cancer surveys, 1997
More than 50 PTK receptors are known to be involved in regulation of cell growth, differentiation, chemotaxis and actin reorganization. PTK receptors can be classified into subfamilies according to their structural features. PTK receptors are activated by ligand induced homo- or heterodimerization, which leads to receptor autophosphorylation on ...
openaire   +1 more source

Regulation of aryl hydrocarbon receptor signal transduction by protein tyrosine kinases

Cellular Signalling, 2005
The involvement of protein tyrosine kinases (PTKs) in aryl hydrocarbon receptor (AhR)-mediated signalling by omeprazole and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was investigated in hepatoma cells. Both omeprazole- and TCDD-dependent AhR signalling was attenuated by inhibition of c-src kinase, either by using pyrazolopyrimidine 4-amino-5-(4 ...
Maria, Backlund, Magnus, Ingelman-Sundberg   +1 more
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Thermal Inactivation of the Protein Tyrosine Kinase of the Epidermal Growth Factor Receptor

Biochemistry, 1996
It has been shown previously that the EGF-stimulable protein tyrosine kinase in a membrane preparation from A431 cells was inactivated by heat shock (45 degrees C), under conditions where EGF binding was unaffected [Carpenter et al. (1979) J. Biol. Chem. 254, 4884-4891].
R A, Stein, J V, Staros
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Annexin I as a Potential Inhibitor of Insulin Receptor Protein Tyrosine Kinase

Biochemical and Biophysical Research Communications, 1994
Insulin receptor (IR) purified from human placenta by wheat germ agglutinin affinity chromatography was incubated in the presence of insulin, [gamma-32P]ATP and annexin I. In parallel to its own tyrosine phosphorylation, annexin I promoted a dose-dependent inhibition of IR autophosphorylation (IC50 0.5 microM).
V, Melki, F, Hullin, H, Mazarguil, J, Fauvel, J M, Ragab-Thomas, H, Chap   +5 more
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Coupling of the IL2 receptor complex with non-receptor protein tyrosine kinases.

Cancer surveys, 1997
IL2 induces the proliferation of T lymphocytes through the IL2 receptor (IL2R) following T lymphocyte activation. The IL2R consists of at least three subunits, IL2R alpha, beta and gamma chains. The cytoplasmic regions of the IL2R beta and gamma chains are critical for transduction of the IL2 signal to the cell interior.
T, Miyazaki, T, Taniguchi
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Non-Receptor Protein Tyrosine Kinases

1995
Roger M. Perlmutter, Steven J. Anderson, Jane A. Gross, Mark W. Appleby   +3 more
openaire   +1 more source