Results 281 to 290 of about 396,884 (345)

Receptor protein tyrosine kinases and phosphatases.

Cold Spring Harbor Symposia on Quantitative Biology, 1992
It is clear that the number of receptor PTKs and PTPs encoded by a typical vertebrate genome is rather large. Although the signal pathways activated by the receptor PTKs may in many cases be common, specificity is provided by the ligand-binding domain and the availability of ligand.
T. Hunter, R. Lindberg, D. Middlemas, S. Tracy, P. Geer   +4 more
semanticscholar   +4 more sources

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The ErbB/HER receptor protein-tyrosine kinases and cancer.

Biochemical and Biophysical Research Communications, 2004
The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor, consist of a growth-factor-binding ectodomain, a single transmembrane segment, an intracellular protein-tyrosine kinase catalytic domain, and a tyrosine-containing cytoplasmic tail.
R. Roskoski
semanticscholar   +4 more sources

Receptor protein-tyrosine kinases and their signal transduction pathways.

Annual Review of Cell Biology, 1994
P. Geer, T. Hunter, R. Lindberg
semanticscholar   +3 more sources

VEGF receptor protein-tyrosine kinases: structure and regulation.

Biochemical and Biophysical Research Communications, 2008
The human VEGF family consists of VEGF (VEGF-A), VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF). The VEGF family of receptors consists of three protein-tyrosine kinases (VEGFR1, VEGFR2, and VEGFR3) and two non-protein kinase co-receptors (neuropilin-1 and neuropilin-2).
R. Roskoski
semanticscholar   +4 more sources

Non-receptor protein tyrosine kinases of normal tissues.

International Journal of Biochemistry, 1990
A. K. Srivastava
semanticscholar   +4 more sources

Signalling Pathways Operated by Receptor Protein Tyrosine Kinases

, 2002
The first RTK discovered was the EGFR. It was also the first receptor that provided evidence for a relationship between activating mutations (oncogenes) and cancer. About 90 genes code for protein tyrosine kinases in the human genome, out of which 58 are receptors (rPTK) and are classified into 20 subfamilies.
B. Gomperts, I. Kramer, P. Tatham
semanticscholar   +3 more sources

Non-Receptor Protein Tyrosine Kinases and Phosphatases in Human Platelets

Thrombosis and Haemostasis, 1996
There is now a large and rapidly growing body of information on the different types of non-receptor tyrosine kinases and phosphatases present within platelets. These enzymes appear to play a critical role in co-ordinating, integrating and amplifying signals from multiple cell surface receptors.
S. Jackson, Simone Schoenwaeider, Yuping Yuan, H. Salem, P. Cooray   +4 more
semanticscholar   +4 more sources

Deceiving appearances: signaling by “dead” and “fractured” receptor protein‐tyrosine kinases

BioEssays, 2000
The mechanisms by which most receptor protein-tyrosine kinases (RTKs) transmit signals are now well established. Binding of ligand results in the dimerization of receptor monomers followed by transphosphorylation of tyrosine residues within the cytoplasmic domains of the receptors.
M. Kroiher, Michael A. Miller, R. Steele
semanticscholar   +4 more sources