Results 21 to 30 of about 156,578 (338)

Substrate Specificity of R3 Receptor-like Protein-tyrosine Phosphatase Subfamily toward Receptor Protein-tyrosine Kinases [PDF]

Journal of Biological Chemistry, 2013
Receptor-like protein-tyrosine phosphatases (RPTPs) are involved in various aspects of cellular functions, such as proliferation, differentiation, survival, migration, and metabolism. A small number of RPTPs have been reported to regulate activities of some cellular proteins including receptor protein-tyrosine kinases (RPTKs).
Juichi Sakuraba, Juichi Sakuraba, Sachiko Tani, Sachiko Tani, Masaharu Noda, Masaharu Noda, Takafumi Shintani, Takafumi Shintani   +7 more
openaire   +3 more sources

Primary extranodal diffuse large B‐cell lymphoma: Molecular features, treatment, and prognosis

Aging and Cancer, Volume 3, Issue 3-4, Page 133-146, September-December 2022., 2022
One‐third of DLBCL arises from extranodal organs and is challenging to manage. Molecular features are critical to elucidate the differences in clinical features, predict the disease prognosis, and improve effective targeted therapeutic strategies. Abstract Diffuse large B‐cell lymphoma (DLBCL) is the most common subtype of non‐Hodgkin's lymphoma and ...
Si‐Yuan Chen, Meng‐Meng Ji, Peng‐Peng Xu, Wei‐Li Zhao   +3 more
wiley   +1 more source

Time-reversal symmetry breaking in the chemosensory array reveals mechanisms for dissipation-enhanced cooperative sensing [PDF]

Nature Communications 15, 8892 (2024), 2023
The Escherichia coli chemoreceptors form an extensive array that achieves cooperative and adaptive sensing of extracellular signals. The receptors control the activity of histidine kinase CheA, which drives a nonequilibrium phosphorylation-dephosphorylation reaction cycle for response regulator CheY.
arxiv   +1 more source

Recent Advances in the Role of Discoidin Domain Receptor Tyrosine Kinase 1 and Discoidin Domain Receptor Tyrosine Kinase 2 in Breast and Ovarian Cancer

Frontiers in Cell and Developmental Biology, 2021
Discoidin domain receptor tyrosine kinases (DDRs) are a class of receptor tyrosine kinases (RTKs), and their dysregulation is associated with multiple diseases (including cancer, chronic inflammatory conditions, and fibrosis).
Li Chen, Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang   +10 more
doaj   +1 more source

Characterization of B61, the Ligand for the Eck Receptor Protein-Tyrosine Kinase [PDF]

Journal of Biological Chemistry, 1995
B61 was originally described as a novel secreted tumor necrosis factor-alpha-inducible gene product in endothelial cells (Holzman, L. B., Marks, R. M., and Dixit, V. M. (1990) Mol. Cell. Biol. 10, 5830-5838). It was recently discovered that soluble recombinant B61 could serve as a ligand for the Eck receptor protein-tyrosine kinase, a member of the Eph/
Vishva M. Dixit, Akhilesh Pandey, Haining Shao, Michael F Seldin, K. S. O'shea   +4 more
openaire   +3 more sources

The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation

Haematologica, 2009
Background Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRβ (TPβ, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRα (FPα ...
Federica Toffalini, Anders Kallin, Peter Vandenberghe, Pascal Pierre, Lucienne Michaux, Jan Cools, Jean-Baptiste Demoulin   +6 more
doaj   +1 more source

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

MedComm, 2022
Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang, Wei Wang, Jia‐Xin Qin, Zhen‐Duo Shi, Lin Hao, Yu‐Yang Ma, Hao Xu, Zhuo‐Xun Wu, Deng Pan, Zhe‐Sheng Chen, Cong‐Hui Han   +10 more
doaj   +1 more source

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons [PDF]

Cellular Signalling 19, 9 (2007) 1996-2002, 2008
gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor activates ERK(1/2) in neurons of the central nervous system, but the molecular mechanisms underlying this ...
arxiv   +1 more source

How the Discovery of the CD4/CD8-p56lck Complexes Changed Immunology and Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
The past 25 years have seen enormous progress in uncovering the receptors and signaling mechanisms on T-cells that activate their various effecter functions.
Christopher E. Rudd, Christopher E. Rudd, Christopher E. Rudd   +2 more
doaj   +1 more source