Results 21 to 30 of about 514,942 (384)
PLoS ONE, 2023 Genomic analysis of the unicellular choanoflagellate, Monosiga brevicollis (MB), revealed the remarkable presence of cell signaling and adhesion protein domains that are characteristically associated with metazoans. Strikingly, receptor tyrosine kinases,
Teena Bajaj +2 more
doaj +1 more source
Phosphoregulators:protein kinases and protein phosphatases of mouse [PDF]
, 2003 With the completion of the human and mouse genome sequences, the task now turns to identifying their encoded transcripts and assigning gene function. In this study, we have undertaken a computational approach to identify and classify all of the protein ...
+7 more
core +2 more sources
Cells, 2020 Helicobacter pylori, a stomach-colonizing Gram-negative bacterium, is the main etiological factor of various gastroduodenal diseases, including gastric adenocarcinoma. By establishing a life-long infection of the gastric mucosa, H.
Marina Leite +8 more
doaj +1 more source
Substrate Specificity of R3 Receptor-like Protein-tyrosine Phosphatase Subfamily toward Receptor Protein-tyrosine Kinases [PDF]
Journal of Biological Chemistry, 2013 Receptor-like protein-tyrosine phosphatases (RPTPs) are involved in various aspects of cellular functions, such as proliferation, differentiation, survival, migration, and metabolism. A small number of RPTPs have been reported to regulate activities of some cellular proteins including receptor protein-tyrosine kinases (RPTKs).
Juichi Sakuraba +7 more
openaire +3 more sources
Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core +2 more sources
Non-receptor protein-tyrosine kinases as molecular targets for antiangiogenic therapy (Review).
International Journal of Molecular Medicine, 2007 Antiangiogenic therapy, including blockade of vascular endothelial growth factor (VEGF) signaling, was highly anticipated to improve the prognosis for patients with advanced cancers following the success of preclinical animal models.
S. Kanda +3 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Discoidin domain receptor tyrosine kinases (DDRs) are a class of receptor tyrosine kinases (RTKs), and their dysregulation is associated with multiple diseases (including cancer, chronic inflammatory conditions, and fibrosis).
Li Chen +10 more
doaj +1 more source
Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]
, 2008 Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad +4 more
core +1 more source
Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling [PDF]
, 2010 The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM).
Eble, J. A. +7 more
core +2 more sources
Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.
Proceedings of the National Academy of Sciences of the United States of America, 1995 Htk is a receptor protein-tyrosine kinase that is related to the EPH subfamily of tyrosine kinases. The receptor has a wide tissue distribution including expression in several myeloid hematopoietic cell lines.
Betsy D. Bennett +6 more
openalex +2 more sources