Results 21 to 30 of about 396,884 (345)

Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis.

PLoS ONE, 2023
Genomic analysis of the unicellular choanoflagellate, Monosiga brevicollis (MB), revealed the remarkable presence of cell signaling and adhesion protein domains that are characteristically associated with metazoans. Strikingly, receptor tyrosine kinases,
Teena Bajaj, John Kuriyan, Christine L Gee   +2 more
doaj   +1 more source

Recent Advances in the Role of Discoidin Domain Receptor Tyrosine Kinase 1 and Discoidin Domain Receptor Tyrosine Kinase 2 in Breast and Ovarian Cancer

Frontiers in Cell and Developmental Biology, 2021
Discoidin domain receptor tyrosine kinases (DDRs) are a class of receptor tyrosine kinases (RTKs), and their dysregulation is associated with multiple diseases (including cancer, chronic inflammatory conditions, and fibrosis).
Li Chen, Li Chen, Xiangyi Kong, Yi Fang, Shishir Paunikar, Xiangyu Wang, James A. L. Brown, James A. L. Brown, Emer Bourke, Xingrui Li, Jing Wang   +10 more
doaj   +1 more source

The fusion proteins TEL-PDGFRβ and FIP1L1-PDGFRα escape ubiquitination and degradation

Haematologica, 2009
Background Chimeric oncogenes encoding constitutively active protein tyrosine kinases are associated with chronic myeloid neoplasms. TEL-PDGFRβ (TPβ, also called ETV6-PDGFRB) is a hybrid protein produced by the t(5;12) translocation, FIP1L1-PDGFRα (FPα ...
Federica Toffalini, Anders Kallin, Peter Vandenberghe, Pascal Pierre, Lucienne Michaux, Jan Cools, Jean-Baptiste Demoulin   +6 more
doaj   +1 more source

Role of protein phosphorylation in cell signaling, disease, and the intervention therapy

MedComm, 2022
Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Kun Pang, Wei Wang, Jia‐Xin Qin, Zhen‐Duo Shi, Lin Hao, Yu‐Yang Ma, Hao Xu, Zhuo‐Xun Wu, Deng Pan, Zhe‐Sheng Chen, Cong‐Hui Han   +10 more
doaj   +1 more source

The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis

Cell Reports, 2020
Summary: PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the murine cortex.
Hideaki Tomita, Francisca Cornejo, Begoña Aranda-Pino, Cameron L. Woodard, Constanza C. Rioseco, Benjamin G. Neel, Alejandra R. Alvarez, David R. Kaplan, Freda D. Miller, Gonzalo I. Cancino   +9 more
doaj   +1 more source

Molecular docking study of new sorafenib analogues as platelet-derived growth factor receptor inhibitors for the treatment of cancer

Journal of Pharmacy and Bioallied Sciences, 2023
Cancer is a disease triggered by an uncontrolled growth of a group of cells usually from a single cell. Chemotherapy is a common and systematic therapy that involves the use of anticancer drugs also known as chemotherapeutical agents to treat cancer ...
Marwan I Jihad, Monther F Mahdi
doaj   +1 more source

Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT

Molecules, 2010
Imaging protein kinase expression with radiolabeled small molecule inhibitors has been actively pursued to monitor the clinical potential of targeted therapeutics and treatments as well as to determine kinase receptor density changes related to disease ...
Justin W. Hicks, Henry F. VanBrocklin, Alan A. Wilson, Sylvain Houle, Neil Vasdev   +4 more
doaj   +1 more source

MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers

Egyptian Journal of Medical Human Genetics, 2021
Background Bladder cancer (BCa) and prostate cancer (PCa) are frequent urothelial and genital malignancies with a high ratio of morbidity and mortality which are more common among males.
Malihe Zangoue, Amir Sadra Zangouei, Majid Mojarrad, Meysam Moghbeli   +3 more
doaj   +1 more source

Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors

Cells
Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer.
Mohammed Hawash
doaj   +1 more source

Molecular insights into kinase mediated signaling pathways of chemokines and their cognate G protein coupled receptors

Frontiers in Bioscience-Landmark, 2020
Chemokines are small regulatory proteins that play a crucial role in the coordinated migration of cell populations to the site of infection/inflammation by binding to their cognate receptors.
Deepak Kumar Tripathi, Krishna Mohan Poluri   +1 more
doaj   +1 more source