Results 1 to 10 of about 940,834 (307)

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. [PDF]

PLoS ONE, 2008
The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
Shiva Akbarzadeh, Lee M Wheldon, Steve M M Sweet, Sonia Talma, Faraz Khosravi Mardakheh, John K Heath   +5 more
doaj   +15 more sources

Receptor tyrosine kinase-mediated angiogenesis. [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
The endothelial cell is the essential cell type forming the inner layer of the vasculature. Two families of receptor tyrosine kinases (RTKs) are almost completely endothelial cell specific: the vascular endothelial growth factor (VEGF) receptors (VEGFR1-3) and the Tie receptors (Tie1 and Tie2). Both are key players governing the generation of blood and
M. Jeltsch, V. Leppänen, P. Saharinen, K. Alitalo   +3 more
semanticscholar   +4 more sources

Tyrosine Kinase Receptors in Oncology [PDF]

International Journal of Molecular Sciences, 2020
Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and differentiation. Consequently, genetic alterations of TKRs may lead to tumorigenesis and, therefore, cancer development.
Jorge Esteban-Villarrubia, Juan José Soto-Castillo, Javier Pozas, María San Román-Gil, Inmaculada Orejana-Martín, Javier Torres-Jiménez, Alfredo Carrato, Teresa Alonso-Gordoa, Javier Molina-Cerrillo   +8 more
openaire   +4 more sources

Second‐line therapy with first‐ or second‐generation tyrosine kinase inhibitors in EGFR‐mutated non‐small cell lung cancer patients with T790M‐negative or unidentified mutation

Thoracic Cancer, 2021
Background T790M mutation causes resistance to tyrosine kinase inhibitors (TKIs) in approximately 49% of patients with epidermal growth receptor‐mutant non‐small cell lung cancer (NSCLC).
Tadashi Nishimura, Tomohito Okano, Masahiro Naito, Soichi Iwanaka, Ayaka Ohiwa, Yasumasa Sakakura, Taro Yasuma, Hajime Fujimoto, Corina N. D'Alessandro‐Gabazza, Yasuhiro Oomoto, Tetsu Kobayashi, Esteban C. Gabazza, Hidenori Ibata   +12 more
doaj   +1 more source

Transglutaminases and receptor tyrosine kinases [PDF]

Amino Acids, 2011
Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling.
Sivaramakrishnan, Manas, Shooter, Gary, Upton, Zee, Croll, Tristan   +3 more
openaire   +4 more sources

MET Receptor Tyrosine Kinase [PDF]

Journal of Thoracic Oncology, 2009
MET receptor tyrosine kinase (RTK) and its ligand hepatocyte growth factor (HGF) have become important therapeutic target in oncology, especially lung cancer. MET RTK is involved in cancer cell growth/survival, motility/migration, invasion/metastasis, and in angiogenesis.
Gustavo M. Cervantes, Ravi Salgia, Essam El-Hashani, Leonardo Faoro   +3 more
openaire   +2 more sources

Receptor Tyrosine Kinases in the Nucleus [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the cell surface to the nucleus in response to ligand binding or heterologous agonist exposure. In most cases, an intracellular domain (ICD) fragment of the receptor is generated at the cell surface and translocated to the nucleus, whereas for a few others the ...
Graham Carpenter, Hong-Jun Liao
openaire   +3 more sources

Endocytosis of Receptor Tyrosine Kinases [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation.
Lai Kuan Goh, Alexander Sorkin
openaire   +3 more sources

Proteolytic Cleavage of Receptor Tyrosine Kinases [PDF]

Biomolecules, 2021
The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular ...
openaire   +3 more sources

An EGFR T790M-mutated lung adenocarcinoma undergoing large-cell neuroendocrine carcinoma transformation after osimertinib therapy: a case report

Journal of Medical Case Reports, 2020
Background Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor–sensitizing and T790M resistance mutations.
Shinichi Miyazaki, Yasumasa Kuno, Shunsaku Hayai, Ryo Teramachi, Ryo Yamashita, Yusuke Saito, Kosuke Higuchi, Yoshiharu Nara, Takuya Ikeda   +8 more
doaj   +1 more source