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Receptor tyrosine kinase-mediated angiogenesis. [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
The endothelial cell is the essential cell type forming the inner layer of the vasculature. Two families of receptor tyrosine kinases (RTKs) are almost completely endothelial cell specific: the vascular endothelial growth factor (VEGF) receptors (VEGFR1 ...
M. Jeltsch, V. Leppänen, P. Saharinen, K. Alitalo   +3 more
semanticscholar   +4 more sources

Skin Toxicities Induced by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and their Influence on Treatment Adjustments in Lung Cancer Patients [PDF]

Acta Dermato-Venereologica
Skin toxicities caused by epidermal growth factor receptor tyrosine kinase inhibitors can affect patient quality of life and lead to treatment adjustments, including dose reduction or discontinuation.
Ji Su Lee, Jimin Woo, Tae Min Kim, Namkyu Kim, Bhumsuk Keam, Seong Jin Jo   +5 more
doaj   +2 more sources

Tyrosine Kinase Receptors in Oncology [PDF]

International Journal of Molecular Sciences, 2020
Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and differentiation. Consequently, genetic alterations of TKRs may lead to tumorigenesis and, therefore, cancer development.
Jorge Esteban-Villarrubia, Juan José Soto-Castillo, Javier Pozas, María San Román-Gil, Inmaculada Orejana-Martín, Javier Torres-Jiménez, Alfredo Carrato, Teresa Alonso-Gordoa, Javier Molina-Cerrillo   +8 more
openaire   +4 more sources

Second‐line therapy with first‐ or second‐generation tyrosine kinase inhibitors in EGFR‐mutated non‐small cell lung cancer patients with T790M‐negative or unidentified mutation

Thoracic Cancer, 2021
Background T790M mutation causes resistance to tyrosine kinase inhibitors (TKIs) in approximately 49% of patients with epidermal growth receptor‐mutant non‐small cell lung cancer (NSCLC).
Tadashi Nishimura, Tomohito Okano, Masahiro Naito, Soichi Iwanaka, Ayaka Ohiwa, Yasumasa Sakakura, Taro Yasuma, Hajime Fujimoto, Corina N. D'Alessandro‐Gabazza, Yasuhiro Oomoto, Tetsu Kobayashi, Esteban C. Gabazza, Hidenori Ibata   +12 more
doaj   +1 more source

MET Receptor Tyrosine Kinase [PDF]

Journal of Thoracic Oncology, 2009
MET receptor tyrosine kinase (RTK) and its ligand hepatocyte growth factor (HGF) have become important therapeutic target in oncology, especially lung cancer. MET RTK is involved in cancer cell growth/survival, motility/migration, invasion/metastasis, and in angiogenesis.
Gustavo M. Cervantes, Ravi Salgia, Essam El-Hashani, Leonardo Faoro   +3 more
openaire   +2 more sources

Transglutaminases and receptor tyrosine kinases [PDF]

Amino Acids, 2011
Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling.
Sivaramakrishnan, Manas, Shooter, Gary, Upton, Zee, Croll, Tristan   +3 more
openaire   +4 more sources

Receptor Tyrosine Kinases in the Nucleus [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the cell surface to the nucleus in response to ligand binding or heterologous agonist exposure. In most cases, an intracellular domain (ICD) fragment of the receptor is generated at the cell surface and translocated to the nucleus, whereas for a few others the ...
Graham Carpenter, Hong-Jun Liao
openaire   +3 more sources

Transformation of Receptor Tyrosine Kinases into Glutamate Receptors and Photoreceptors [PDF]

Angewandte Chemie International Edition, 2020
AbstractReceptor tyrosine kinases (RTKs) are key regulators of cellular functions in metazoans. In vertebrates, RTKs are mostly activated by polypeptides but are not naturally sensitive to amino acids or light. Taking inspiration from Venus kinase receptors (VKRs), an atypical family of RTKs found in nature, we have transformed the human insulin (hIR ...
Dirk Trauner, Dirk Trauner, Marion Morel, Jérôme Vicogne, Colette Dissous, Philipp Leippe, Johannes Broichhagen, Alexandra Mougel, Katia Cailliau   +8 more
openaire   +8 more sources

Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis [PDF]

International Journal of Basic Science in Medicine, 2019
Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies.
Maryam Poursadeghfard, Sara Azhdari
doaj   +1 more source

Endocytosis of Receptor Tyrosine Kinases [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation.
Lai Kuan Goh, Alexander Sorkin
openaire   +3 more sources