Results 1 to 10 of about 585,906 (351)
The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. [PDF]
PLoS ONE, 2008 The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
Shiva Akbarzadeh +5 more
doaj +8 more sources
Skin Toxicities Induced by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and their Influence on Treatment Adjustments in Lung Cancer Patients [PDF]
Acta Dermato-VenereologicaSkin toxicities caused by epidermal growth factor receptor tyrosine kinase inhibitors can affect patient quality of life and lead to treatment adjustments, including dose reduction or discontinuation.
Ji Su Lee +5 more
doaj +2 more sources
Tyrosine Kinase Receptors in Oncology [PDF]
International Journal of Molecular Sciences, 2020 Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and differentiation. Consequently, genetic alterations of TKRs may lead to tumorigenesis and, therefore, cancer development.
Jorge Esteban-Villarrubia +8 more
openaire +4 more sources
Thoracic Cancer, 2021 Background T790M mutation causes resistance to tyrosine kinase inhibitors (TKIs) in approximately 49% of patients with epidermal growth receptor‐mutant non‐small cell lung cancer (NSCLC).
Tadashi Nishimura +12 more
doaj +1 more source
Transglutaminases and receptor tyrosine kinases [PDF]
Amino Acids, 2011 Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling.
Sivaramakrishnan, Manas +3 more
openaire +4 more sources
MET Receptor Tyrosine Kinase [PDF]
Journal of Thoracic Oncology, 2009 MET receptor tyrosine kinase (RTK) and its ligand hepatocyte growth factor (HGF) have become important therapeutic target in oncology, especially lung cancer. MET RTK is involved in cancer cell growth/survival, motility/migration, invasion/metastasis, and in angiogenesis.
Gustavo M. Cervantes +3 more
openaire +2 more sources
Receptor Tyrosine Kinases in the Nucleus [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the cell surface to the nucleus in response to ligand binding or heterologous agonist exposure. In most cases, an intracellular domain (ICD) fragment of the receptor is generated at the cell surface and translocated to the nucleus, whereas for a few others the ...
Graham Carpenter, Hong-Jun Liao
openaire +3 more sources
Endocytosis of Receptor Tyrosine Kinases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation.
Lai Kuan Goh, Alexander Sorkin
openaire +3 more sources
Proteolytic Cleavage of Receptor Tyrosine Kinases [PDF]
Biomolecules, 2021 The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular ...
openaire +3 more sources
Journal of Medical Case Reports, 2020 Background Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor–sensitizing and T790M resistance mutations.
Shinichi Miyazaki +8 more
doaj +1 more source