Results 1 to 10 of about 620,852 (356)
The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. [PDF]
PLoS ONE, 2008 The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
Shiva Akbarzadeh +5 more
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Proteolytic Cleavage of Receptor Tyrosine Kinases [PDF]
Biomolecules, 2021 The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular ...
Hao Huang
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Cell Signaling by Receptor Tyrosine Kinases [PDF]
Cell, 2010 Recent structural studies of receptor tyrosine kinases (RTKs) have revealed unexpected diversity in the mechanisms of their activation by growth factor ligands. Strategies for inducing dimerization by ligand binding are surprisingly diverse, as are mechanisms that couple this event to activation of the intracellular tyrosine kinase domains.
Mark A. Lemmon, Joseph Schlessinger
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Tyrosine Kinase Receptors in Oncology [PDF]
International Journal of Molecular Sciences, 2020 Tyrosine kinase receptors (TKR) comprise more than 60 molecules that play an essential role in the molecular pathways, leading to cell survival and differentiation. Consequently, genetic alterations of TKRs may lead to tumorigenesis and, therefore, cancer development.
Jorge Esteban-Villarrubia +8 more
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Transglutaminases and receptor tyrosine kinases [PDF]
Amino Acids, 2011 Transglutaminases are confounding enzymes which are known to play key roles in various cellular processes. In this paper, we aim to bring together several pieces of evidence from published research and literature that suggest a potentially vital role for transglutaminases in receptor tyrosine kinases (RTK) signalling.
Sivaramakrishnan, Manas +3 more
openaire +3 more sources
Thoracic Cancer, 2021 Background T790M mutation causes resistance to tyrosine kinase inhibitors (TKIs) in approximately 49% of patients with epidermal growth receptor‐mutant non‐small cell lung cancer (NSCLC).
Tadashi Nishimura +12 more
doaj +1 more source
Endocytosis of Receptor Tyrosine Kinases [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Endocytosis is the major regulator of signaling from receptor tyrosine kinases (RTKs). The canonical model of RTK endocytosis involves rapid internalization of an RTK activated by ligand binding at the cell surface and subsequent sorting of internalized ligand-RTK complexes to lysosomes for degradation.
Lai Kuan, Goh, Alexander, Sorkin
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Receptor Tyrosine Kinases in the Nucleus [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the cell surface to the nucleus in response to ligand binding or heterologous agonist exposure. In most cases, an intracellular domain (ICD) fragment of the receptor is generated at the cell surface and translocated to the nucleus, whereas for a few others the ...
Graham, Carpenter, Hong-Jun, Liao
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Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis [PDF]
International Journal of Basic Science in Medicine, 2019 Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies.
Maryam Poursadeghfard, Sara Azhdari
doaj +1 more source
Journal of Medical Case Reports, 2020 Background Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor, is selective for both epidermal growth factor receptor tyrosine kinase inhibitor–sensitizing and T790M resistance mutations.
Shinichi Miyazaki +8 more
doaj +1 more source