Results 231 to 240 of about 590,153 (303)

Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

, 1991
Susan O. Meakin, E.M. Shooter
openalex   +1 more source

Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer

Advanced Science, EarlyView.
Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska, Paula Allepuz‐Fuster, Chloé Maurizy, Alexandre Hego, Sandra Ormenese, Quentin Lion, Arnaud Blomme, Pierre Close, Arnaud Lavergne, Latifa Karim, Marc Thiry, Ivan Nemazanyy, Roopesh Krishnankutty, Jair Marques Jr, Alex von Kriegsheim, Nathaniel F. Henneman, Ganna Panasyuk, Kateryna Shostak, Alain Chariot   +18 more
wiley   +1 more source

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

, 1991
J P O'Bryan, R A Frye, P C Cogswell, A Neubauer, B Kitch, C Prokop, R Espinosa, Michelle M. Le Beau, H S Earp, E T Liu   +9 more
openalex   +2 more sources

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.

Biochemical and Biophysical Research Communications - BBRC, 1992
B. I. Terman, M. Dougher-Vermazen, Miguel Eduardo Carrion, Dragan Dimitrov, D. Armellino, D. Gospodarowicz, P. Bőhlen   +6 more
semanticscholar   +1 more source

Identification and Drug Screening of Single Cells from Human Tumors on Semiconductor Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
The study innovatively integrates single‐cell electric impedance identification and drug screening on a semiconductor chip, addressing tumor heterogeneity limitations. The system achieves label‐free cancer cell recognition while concurrently evaluating drug efficacy on cancer cells and toxicity on noncancerous cells.
Wenhao Hui, Ka‐Meng Lei, Yingying Liu, Xinru Huang, Yunlong Zhong, Xiaojun Chen, Mingji Wei, Jie Yan, Ren Shen, Pui‐In Mak, Rui P. Martins, Shuhong Yi, Ping Wang, Yanwei Jia   +13 more
wiley   +1 more source

LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5

Advanced Science, EarlyView.
Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li, Zhuo‐Ran Liang, Zhi‐Chao Liu, Xue‐Ping Luo, Jun‐Yi Li, Xiao‐Mei Yu, Xuan‐Zhang Huang, Yan He, Tao‐Yang Xu, Jiao‐Jiao Xu, Shao‐Cong Peng, Yu‐Xiang Song, Yan He, Xiao‐Wan Zhuang, Can‐Can Zheng, Fan Zhang, Alfred King‐Yin Lam, Wei Dai, Ming‐Liang He, Bo Liu, Qi Zhao, Guo‐Liang Lu, Jin‐Bao Liu, Zhen‐Ning Wang, Zhi‐Gang Li, Ze‐Xian Liu, Wen‐Wen Xu, Bin Li   +27 more
wiley   +1 more source

The dual EGF/VEGF receptor tyrosine kinase inhibitor AEE788 inhibits growth of human hepatocellular carcinoma xenografts in nude mice

, 1992
Matthias Ocker
openalex   +2 more sources

Changes in insulin-receptor structure associated with trypsin-induced activation of the receptor tyrosine kinase [PDF]

, 1991
Stella Clark, Glenn S. Eckardt, Kenneth Siddle, Len C. Harrison   +3 more
openalex   +1 more source

Blood Biomarker‐Based Predictive Indicator for Liver Metastasis in Alpha‐Fetoprotein‐Producing Gastric Cancer and Multi‐Omics Tumor Microenvironment Insights

Advanced Science, EarlyView.
Alpha‐fetoprotein‐producing gastric cancer (AFPGC), a rare and aggressive subtype of gastric cancer, presents a high risk of liver metastasis. This study introduces the ANLiM score, a blood biomarker‐based predictive indicator for assessing liver metastasis and immunotherapy response.
Yongfeng Ding, Yiran Chen, Jing Zhang, Qingrui Wang, Songting Zhu, Junjie Jiang, Chao He, Jincheng Wang, Laizhen Tou, Jingwei Zheng, Bicheng Chen, Sizhe Hu, Xiongfei Yu, Haohao Wang, Yimin Lu, Mei Kong, Yanyan Chen, Haiyong Wang, Haibin Zhang, Hongxia Xu, Fei Teng, Xian Shen, Nong Xu, Jian Ruan, Zhan Zhou, Jun Lu, Lisong Teng   +26 more
wiley   +1 more source

Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors

, 1991
Sophie Tartare, Robert Ballotti, Reiner Lammers, F Alengrin, Thomas J. Dull, Joseph Schlessinger, A. Ullrich, E Van Obberghen   +7 more
openalex   +1 more source