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ErbB-4: a receptor tyrosine kinase
Inflammation Research, 2002ErbB-4 is a receptor tyrosine kinase that is activated by the binding of specific growth factors to its ectodomain. In addition to the initiation of signal transduction pathways that direct cell responses, such as proliferation or differentiation, this receptor is subject to ligand-dependent trafficking events.
G. Carpenter, W. Zhou
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Allosteric targeting of receptor tyrosine kinases
Nature Biotechnology, 2014The drug discovery landscape has been transformed over the past decade by the discovery of allosteric modulators of all major mammalian receptor superfamilies. Allosteric ligands are a rich potential source of drugs and drug targets with clear therapeutic advantages.
Arthur Christopoulos +2 more
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Non-receptor protein tyrosine kinases
Frontiers in Bioscience, 2003The protein tyrosine kinases (PTKs) are enzymes catalyzing the transfer of the gamma-phosphate group of ATP to the hydroxyl groups of specific tyrosine residues in peptides. Although phosphotransfer reactions catalyzed by various PTKs are similar with regard to their basic mechanisms, their biological functions demonstrate a considerable degree of ...
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Forthcoming receptor tyrosine kinase inhibitors
Expert Opinion on Therapeutic Targets, 2006Receptor tyrosine kinases play a significant role in carcinogenesis and have been successfully targeted with monoclonal antibodies and small-molecule inhibitors. There have been recent developments in the understanding of receptor tyrosine kinase signal transduction which have enabled better drug development.
Ezra E.W. Cohen, Nicholas W. Choong
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SIGNALLING BY RECEPTOR TYROSINE KINASES [PDF]
Annual Review of Biochemistry, 1993 Lewis T. Williams +2 more
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Tyrosine kinase phosphorylation of GABAA receptors
Molecular Brain Research, 1995Phosphorylation of purified bovine brain GABAA receptors by the tyrosine kinase, pp60v-src was examined. pp60v-src phosphorylated two bands of 54-62 kDa and 48-51 kDa that migrated to approximately the same position as bands recognized by antisera against the beta 2 and gamma 2 GABAA receptor subunits, respectively.
Geoffrey B. Smith +10 more
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Signal transduction by receptor tyrosine kinases
1993Many oncogenes exert proliferative effects on cells by influencing signal transduction pathways. Signal transduction provides a means for cells to propagate and amplify signals received from the environment to specific targets within the cell. The culmination of this pathway is DNA synthesis and cell division.
Archibald Perkins +2 more
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Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
Nature, 1995G. Fong +3 more
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Structure and function of tyrosine kinase receptors
Journal of Bioenergetics and Biomembranes, 1991Over the past ten years, several growth factor receptors have been shown to be ligand-regulated tyrosine kinases. Tyrosine kinase activity is essential for signal transmission, suggesting that phosphorylation cascades may play an important role. Considerable effort has gone into understanding the structure and function of tyrosine kinase receptors in ...
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