Results 271 to 280 of about 590,153 (303)

Quantitative Analysis of Fluorescent Sensor Arrays

Analysis &Sensing, Accepted Article.
Fluorescent sensor arrays address the limitations of a single sensor by leveraging multiple sensing elements to generate unique response patterns for each of the analyte of interest. This approach has emerged as a powerful tool for identifying and analysing intricate chemical and biological environments using various multivariate analytical tools such ...
Karandeep Grover, Muhammad Tahir Waseem, Haobo Guo, Elizabeth New   +3 more
wiley   +1 more source

Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley IV, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +18 more
wiley   +1 more source

Antifibrotic effects of specific targeting of the 5‐hydroxytryptamine 2B receptor (5‐HT2BR) in murine models and ex vivo models of scleroderma skin

Arthritis &Rheumatology, EarlyView.
Objective Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case‐specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options.
Thuong Trinh‐Minh, Cuong Tran‐Manh, Andrea‐Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H. W. Distler   +12 more
wiley   +1 more source

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The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor.

Science, 1992
The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular ...
C. D. Vries, J. Escobedo, H. Ueno, K. Houck, N. Ferrara, L. Williams   +5 more
semanticscholar   +1 more source

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

Science, 1985
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene ...
L. Coussens, Teresa L. Yang−Feng, Y. Liao, E. Chen, A. Gray, J. Mcgrath, P. Seeburg, T. Libermann, J. Schlessinger, U. Francke, A. Levinson, A. Ullrich   +11 more
semanticscholar   +1 more source

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

Science, 1997
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds from this class inhibited the kinase activity of fibroblast growth factor receptor 1 (FGFR1) and showed differential ...
M. Mohammadi, G. Mcmahon, Li Sun, C. Tang, P. Hirth, Brian K. Yeh, S. Hubbard, J. Schlessinger   +7 more
semanticscholar   +1 more source

Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor.

Blood, 2000
STI 571 (formerly known as CGP 57148B) is a known inhibitor of the c-abl, bcr-abl, and platelet-derived growth-factor receptor (PDGFR) tyrosine kinases. This compound is being evaluated in clinical trials for the treatment of chronic myelogenous leukemia.
M. Heinrich, D. Griffith, B. Druker, C. Wait, Kristen A. Ott, A. J. Zigler   +5 more
semanticscholar   +1 more source

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

Nature, 1995
G. Fong, J. Rossant, M. Gertsenstein, M. Breitman   +3 more
semanticscholar   +1 more source

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Science, 1996
G. Hotamisligil, P. Peraldi, A. Budavari, Ramsey Ellis, M. White, B. Spiegelman   +5 more
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly