Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy
Journal of Hematology & Oncology, 2019 Angiogenesis has always been the topic of major scientific interest in the field of malignant tumors. Nowadays, targeting angiogenesis has achieved success in various carcinomas by several mechanisms, including the use of anti-angiogenic small molecule ...
Shuang Qin +5 more
semanticscholar +1 more source
PLoS ONE, 2023 Rheumatoid arthritis is an inflammatory autoimmune disease, characterized by autoantibody production, synovial inflammation, and joint destruction. Its pathogenesis is due to environmental factors and genetic backgrounds.
Daichi Akasaka +9 more
doaj +2 more sources
Tumor Biology, 2017 The finding of epidermal growth factor receptor tyrosine kinase inhibitors, which reflects a classical process of translational research, is a critical milestone for non-small-cell lung cancer treatment.
Shaohua Cui, Liyan Jiang
doaj +1 more source
Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]
, 2014 Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean +3 more
core +2 more sources
Receptor Tyrosine Kinase-Targeted Cancer Therapy
International Journal of Molecular Sciences, 2018 In the past two decades, several molecular targeted inhibitors have been developed and evaluated clinically to improve the survival of patients with cancer. Molecular targeted inhibitors inhibit the activities of pathogenic tyrosine kinases. Particularly,
T. Yamaoka +4 more
semanticscholar +1 more source
Insulin receptor has tyrosine kinase activity toward Shc in rat liver
Brazilian Journal of Medical and Biological Research, 1998 Insulin induces tyrosine phosphorylation of Shc in cell cultures and in insulin-sensitive tissues of the intact rat. However, the ability of insulin receptor (IR) tyrosine kinase to phosphorylate Shc has not been previously demonstrated.
E.V. Páez-Espinosa +3 more
doaj +1 more source
Inhibition of tyrosine kinase activity decreases expression of surfactant protein A in a human lung adenocarcinoma cell line independent of epidermal growth factor receptor [PDF]
, 1997 Epidermal growth factor (EGF) enhances fetal lung development in vivo and in vitro. Ligand binding to the EGF receptor stimulates an intrinsic receptor tyrosine kinase initiating a signal transduction cascade.
Klein, Jonathan M, McCarthy, Troy A
core +1 more source
AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling
Cell Communication and Signaling, 2023 Background Gonadotropin-releasing hormone (GnRH) receptors are essential for reproduction and are expressed in numerous urogenital, reproductive, and non-reproductive cancers.
Pardis Mohammadzadeh +2 more
doaj +1 more source
A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. [PDF]
, 2012 EphB receptor tyrosine kinases control multiple steps in nervous system development. However, it remains unclear whether EphBs regulate these different developmental processes directly or indirectly.
Ataman, Bulent +12 more
core +1 more source
Anaplastic Lymphoma Kinase (ALK) Receptor Tyrosine Kinase: A Catalytic Receptor with Many Faces
International Journal of Molecular Sciences, 2018 The anaplastic lymphoma kinase (ALK) receptor is a membrane-bound tyrosine kinase. The pathogenesis of several cancers is closely related to aberrant forms of ALK or aberrant ALK expression, including ALK fusion proteins, ALK-activated point mutations ...
Hao Huang
semanticscholar +1 more source