Results 1 to 10 of about 151 (123)

Toll-like receptors [PDF]

Current Biology, 2011
SummaryBeginning with the physical barrier presented by the epithelium, infectious agents such as viruses and bacteria encounter an array of cellular and molecular countermeasures that evolved within the host to resist them. Host immune responses are of two types, termed innate and adaptive.
Moresco, Eva Marie Y., LaVine, Diantha, Beutler, Bruce   +2 more
openaire   +2 more sources

TYK2‐Inhibition: Potenzial bei der Behandlung chronisch‐entzündlicher Immunerkrankungen

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 19, Issue 10, Page 1409-1420, October 2021., 2021
Zusammenfassung In den letzten Jahrzehnten sind immunvermittelte chronisch‐entzündliche Krankheiten zu führenden Ursachen für Morbidität und Mortalität in westlichen Ländern geworden. Obwohl zahlreiche Faktoren als ursächlich für diese Erkrankungen vermutet werden, ist eine vereinende Ätiologie nach wie vor unbekannt.
Kamran Ghoreschi, Matthias Augustin, Xenofon Baraliakos, Gerhard Krönke, Matthias Schneider, Stefan Schreiber, Hendrik Schulze‐Koops, Sebastian Zeißig, Diamant Thaçi   +8 more
wiley   +1 more source

Toll-like Receptors and Thrombopoiesis

International Journal of Molecular Sciences, 2023
Platelets are the second most abundant blood component after red blood cells and can participate in a variety of physiological and pathological functions. Beyond its traditional role in hemostasis and thrombosis, it also plays an indispensable role in inflammatory diseases. However, thrombocytopenia is a common hematologic problem in the clinic, and it
Xiaoqin Tang, Qian Xu, Shuo Yang, Xinwu Huang, Long Wang, Feihong Huang, Jiesi Luo, Xiaogang Zhou, Anguo Wu, Qibing Mei, Chunling Zhao, Jianming Wu   +11 more
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Toll-Like Receptors in Neurodegeneration [PDF]

Brain Research Reviews, 2009
Innate pattern recognition receptors are implicated in first-line defense against pathogens but also participate in maintenance of tissue homeostasis and response to injury. This chapter reviews the role of Toll-like receptors (TLRs) in neuronal and glial responses that are associated with neurodegeneration.
Okun, Eitan, Griffioen, Kathleen J., Lathia, Justin D., Tang, Sung-Chun, Mattson, Mark P., Arumugam, Thiruma V.   +5 more
openaire   +7 more sources

COVID‐19 und Immunregulation – von grundlegenden und translationalen Aspekten zu klinischen Implikationen

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 8, Page 795-809, August 2020., 2020
Zusammenfassung Die durch SARS‐CoV‐2 verursachte Pandemie COVID‐19 hat weitreichende direkte und indirekte medizinische Folgen. Dazu gehören sowohl der Verlauf als auch die Behandlung vieler Krankheiten. Es wird immer deutlicher, dass Infektionen mit SARS‐CoV‐2 erhebliche immunologische Veränderungen verursachen können, die insbesondere auch ...
Michael P. Schön, Carola Berking, Tilo Biedermann, Timo Buhl, Luise Erpenbeck, Kilian Eyerich, Stefanie Eyerich, Kamran Ghoreschi, Matthias Goebeler, Ralf J. Ludwig, Knut Schäkel, Bastian Schilling, Christoph Schlapbach, Georg Stary, Esther von Stebut, Kerstin Steinbrink   +15 more
wiley   +1 more source

Vitiligo‐ähnliche Depigmentierung in der Folge eines subakut kutanen Lupus erythematodes und Hydroxychloroquin‐Behandlung

, 2020
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 18, Issue 12, Page 1470-1474, December 2020.
Dennis Niebel, Christine Braegelmann, Thomas Bieber, Joerg Wenzel   +3 more
wiley   +1 more source

Toll-like receptors in COPD [PDF]

European Respiratory Journal, 2017
TLR4 and NODs could be potential therapeutic targets in chronic obstructive pulmonary diseasehttp://ow.ly ...
Hansbro, Philip M., Haw, Tatt Jhong, Starkey, Malcolm R., Miyake, Kensuke   +3 more
openaire   +2 more sources

Toll-like receptors as adjuvant receptors

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2002
The mammalian Toll-like receptors (TLRs) are expressed on macrophages and dendritic cells, which are primarily involved in innate immunity. At present, ligands for several of the TLRs, such as TLR2, TLR3, TLR4, TLR5, TLR6, and TLR9, have been identified.
Kaisho, Tsuneyasu, Akira, Shizuo
openaire   +2 more sources

Toll-Like Receptors in Angiogenesis [PDF]

The Scientific World JOURNAL, 2011
Toll-like receptors (TLRs) are known as pattern-recognition receptors related to the Toll protein ofDrosophila. After recognition of pathogen-associated molecular patterns of microbial origin, the TLRs alert the immune system, and initiate innate and adaptive immune responses.
Karsten Grote, Harald Schütt, Bernhard Schieffer   +2 more
openaire   +3 more sources

Toll-like Receptors and the Eye [PDF]

Investigative Opthalmology & Visual Science, 2006
The immune response to microbial pathogens relies on both innate and adaptive components.1 The innate or immediate response is mediated in large measure by leukocytes of the blood, such as neutrophils (PMNs) and macrophages, cells that phagocytose and kill the pathogens and that concurrently coordinate additional host responses by synthesis of a wide ...
Fu-Shin X, Yu, Linda D, Hazlett
openaire   +2 more sources