Results 201 to 210 of about 37,629 (265)
Some of the next articles are maybe not open access.
Alpha-Adrenergic Receptor Subtypes
New England Journal of Medicine, 1980CATECHOLAMINES modulate a host of diverse responses in man. These responses are initiated by the interaction of catecholamines with discrete sites located on the plasma membrane of cells. Adrenergic receptors, like other hormone receptors, are responsible for the selective recognition and binding of specific molecular structures, in this case ...
B B, Hoffman, R J, Lefkowitz
openaire +2 more sources
Alpha-adrenergic receptors on human platelets
Life Sciences, 1977Abstract [3H] dihydroergocyrptine, an α-adrenergic antagonist, binds specifically to sites on human platelet membranes. Prostaglandin E1 (PGE1) stimulates the production of cyclic AMP (cAMP) in human platelets. Alpha-adrenergic agonists, 1-epinephrine and 1-norepinephrine, and antagonists, phentolamine, phenoxybenzamine, and dihydroergocyrptine ...
M S, Kafka +3 more
openaire +2 more sources
Alpha-Adrenergic Receptors In Rabbit Eyes
Journal of Ocular Pharmacology and Therapeutics, 1985The IOP and pupil response to alpha-adrenergic agonists and blockers was studied in albino rabbits. Topical ocular application of solutions of methoxamine (alpha 1) and oxymetazoline (alpha 2) caused dose-related early rises in IOP which were inhibited by pretreatment with prazosin, an alpha 1-blocker, or with yohimbine, an alpha 2-blocker.
D L, Murray, I H, Leopold
openaire +2 more sources
Structure and Function of Alpha-Adrenergic Receptors
The American Journal of Medicine, 1989Alpha 1- and alpha 2-adrenergic receptors are the initial recognition sites on a wide variety of catecholamine-responsive target cells. This article addresses several major questions related to subtypes, structure, signal transduction mechanisms, and regulation of alpha 1- and alpha 2-adrenergic receptors.
openaire +2 more sources
Central alpha adrenergic receptors in thermoregulation
Neuropharmacology, 1972Abstract Alpha and beta adrenergic receptor blocking agents were injected into the cerebral ventricles of unanesthetized cats and their effects on subsequent responses to intraventricular norepinephrine were determined. The alpha receptor blocking agent phentolamine (100 μg) antagonized the hypothermie and emetic responses to 100 μg norepinephrine ...
openaire +2 more sources
Heterogeneity of alpha-2 adrenergic receptors
Pharmacology Biochemistry and Behavior, 1985Alpha adrenergic receptors are subdivided into alpha-1 and alpha-2 subtypes on the basis of their pharmacologic properties. An evaluation of data from radioligand binding and functional experiments indicates that the receptors classified as alpha-2 are not a homogeneous group.
openaire +2 more sources
alpha1-Adrenergic Receptor Subtypes
Annual Review of Pharmacology and Toxicology, 1994Investigators have not yet reached a consensus on the number and signaling mechanisms of alpha 1-adrenergic receptor (AR) subtypes. Two native subtypes (alpha 1A and alpha 1B) can be distinguished pharmacologically, and three subtypes (alpha 1B, alpha 1C, and alpha 1D) have been cloned.
K P, Minneman, T A, Esbenshade
openaire +2 more sources
The hepatic alpha1-adrenergic receptor
Biochemical Pharmacology, 1984Since the relatively recent advent of radioligand binding techniques, it has been possible to directly identify and characterize hepatic adrenergic receptors as well as study their physiological regulation. While it is now clear that alpha 1-adrenergic receptors constitute the major population of hepatic adrenergic receptors and are primarily ...
M, Goodhardt +3 more
openaire +2 more sources
Alpha 2A adrenergic receptor gene and suicide
Psychiatry Research, 2004Suicide is a complex trait resulting from the interaction of several predisposing factors, among which genes seem to play an important role. Alterations in the noradrenergic system have been observed in postmortem brain studies of suicide victims when compared to controls.
Adolfo, Sequeira +8 more
openaire +2 more sources