Results 251 to 260 of about 85,891 (312)
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Alpha-adrenergic receptors on human platelets
Life Sciences, 1977Abstract [3H] dihydroergocyrptine, an α-adrenergic antagonist, binds specifically to sites on human platelet membranes. Prostaglandin E1 (PGE1) stimulates the production of cyclic AMP (cAMP) in human platelets. Alpha-adrenergic agonists, 1-epinephrine and 1-norepinephrine, and antagonists, phentolamine, phenoxybenzamine, and dihydroergocyrptine ...
M S, Kafka +3 more
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Alpha-Adrenergic Receptors In Rabbit Eyes
Journal of Ocular Pharmacology and Therapeutics, 1985The IOP and pupil response to alpha-adrenergic agonists and blockers was studied in albino rabbits. Topical ocular application of solutions of methoxamine (alpha 1) and oxymetazoline (alpha 2) caused dose-related early rises in IOP which were inhibited by pretreatment with prazosin, an alpha 1-blocker, or with yohimbine, an alpha 2-blocker.
D L, Murray, I H, Leopold
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Alpha 1-adrenergic receptor structure.
Molecular Pharmacology, 1984The structure of the alpha 1-adrenergic receptor was investigated by comparing polypeptides identified by sodium dodecyl sulfate (NaDodSO4)-polyacrylamide gel electrophoresis with the size of the intact receptor in cell membranes as determined by target size analysis.
J C, Venter +4 more
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1988
The actions of epinephrine, an adrenal hormone and central neurotransmitter, and norepinephrine, a peripheral sympathetic and central neurotransmitter, are mediated through alpha-1, alpha-2, and beta-adrenergic receptors. In addition, a variety of drugs also produce their effects by interacting with these receptors. alpha-2 Adrenergic agonists, such as
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The actions of epinephrine, an adrenal hormone and central neurotransmitter, and norepinephrine, a peripheral sympathetic and central neurotransmitter, are mediated through alpha-1, alpha-2, and beta-adrenergic receptors. In addition, a variety of drugs also produce their effects by interacting with these receptors. alpha-2 Adrenergic agonists, such as
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Central alpha adrenergic receptors in thermoregulation
Neuropharmacology, 1972Abstract Alpha and beta adrenergic receptor blocking agents were injected into the cerebral ventricles of unanesthetized cats and their effects on subsequent responses to intraventricular norepinephrine were determined. The alpha receptor blocking agent phentolamine (100 μg) antagonized the hypothermie and emetic responses to 100 μg norepinephrine ...
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Heterogeneity of alpha-2 adrenergic receptors
Pharmacology Biochemistry and Behavior, 1985Alpha adrenergic receptors are subdivided into alpha-1 and alpha-2 subtypes on the basis of their pharmacologic properties. An evaluation of data from radioligand binding and functional experiments indicates that the receptors classified as alpha-2 are not a homogeneous group.
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Alpha 2A adrenergic receptor gene and suicide
Psychiatry Research, 2004Suicide is a complex trait resulting from the interaction of several predisposing factors, among which genes seem to play an important role. Alterations in the noradrenergic system have been observed in postmortem brain studies of suicide victims when compared to controls.
Adolfo, Sequeira +8 more
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Alpha-2 Adrenergic Receptor Agonists
2014Alpha-2 adrenergic receptor agonists include clonidine, guanfacine, guanabenz, methyldopa, rilmenidine, and moxonidine. These are centrally active antihypertensive drugs.
Esen Özkaya +1 more
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Structure and Function of Alpha-Adrenergic Receptors
The American Journal of Medicine, 1989Alpha 1- and alpha 2-adrenergic receptors are the initial recognition sites on a wide variety of catecholamine-responsive target cells. This article addresses several major questions related to subtypes, structure, signal transduction mechanisms, and regulation of alpha 1- and alpha 2-adrenergic receptors.
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The alpha-1 Adrenergic Receptors
1987Section 1: Historical Perspectives.- 1 alpha-1 Adrenergic Receptors: A Historical Perspective.- 1. Introduction.- 2. Adrenotropic Receptors.- 3. Receptor Blockers.- 4. Recent Developments.- 5. Conclusion.- References.- Section 2: Characterization of the Receptor and Its Binding Site.- 2 Biochemistry and Pharmacology of the alpha-1 Adrenergic Receptor.-
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