Results 201 to 210 of about 93,900,112 (260)

Running‐based rehabilitation does not improve muscle function after volumetric muscle loss despite improving hindlimb weight‐bearing asymmetry in mice

Experimental Physiology, EarlyView.
Abstract Volumetric muscle loss (VML) is a traumatic skeletal muscle injury characterized by chronic functional impairments in the affected muscle and adjacent uninjured bone. Rehabilitative strategies aimed at restoring limb function following VML, including voluntary running, have shown limited efficacy and in some cases have been detrimental.
Angela S. Bruzina, Molly R. Weberg, Ryan J. Willoughby, Gordon L. Warren, Jarrod A. Call, Sarah M. Greising   +5 more
wiley   +1 more source

Simultaneous acquisition of maternal and dual‐fetal electrocardiography with maternal haemodynamic monitoring in anaesthetized pregnant rats

Experimental Physiology, EarlyView.
Abstract Experimental approaches that acquire maternal haemodynamics together with direct cardiac signals from more than one fetus remain limited. We developed a standardized in vivo method for simultaneous acquisition of maternal ECG, maternal arterial blood pressure and ECGs from two fetuses in anaesthetized late‐gestation Sprague–Dawley rats.
Sarah Pribil Pardun, Spencer Duff, Payton Ward, Auspy Li, Lie Gao   +4 more
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

TMEM16A Ca2+‐activated Cl− channel: Functional interactions with cytoskeletal and membrane‐associated proteins

The Journal of Physiology, EarlyView.
Abstract figure legend The calcium‐activated chloride (ClCa) channel TMEM16A (also known as ANO1) plays critical roles in ion transport, neurotransmission and smooth muscle contraction. Dysregulation of TMEM16A channel activity contributes to the development and progression of various diseases.
Hisao Yamamura, Rubii Kondo, Yoshiaki Suzuki, Yuji Imaizumi, Aya Yamamura   +4 more
wiley   +1 more source

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Genetic variation in the beta-3-adrenergic receptor in essential hypertension

Life Sciences, 2000
We investigated the role of the beta-3-adrenergic receptor polymorphism in membrane lipid composition and erythrocyte membrane sodium transport in essential hypertensive patients. We studied 87 essential hypertensive patients determining: The Trp64Arg mutation of the beta-3-adrenergic receptor by PCR, lipoprotein profile by standard laboratory methods,
E, Pamies-Andreu, R, García-Lozano, C, Palmero-Palmero, S, García-Morillo, A, Alonso-Arcas, P, Stiefel, J, Carneado de la Fuente, J, Villar   +7 more
openaire   +2 more sources

Beta 3-adrenergic receptor is involved in feeding regulation in chicks

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2003
We examined whether the brain beta 3-adrenergic receptor (B3-AR) is involved in the feeding regulation of chicks. Intracerebroventricular (ICV) injection of BRL37344, a B3-AR agonist, reduced food intake of chicks under ad libitum, but not fasting, feeding conditions.
Tetsuya, Tachibana, Tomo, Takagi, Ei Suke, Saito, Shozo, Tomonaga, Rong, Zhang, Yusuke, Koga, Yasuhiro, Kido, Donald, Michael Denbow, Mitsuhiro, Furuse   +8 more
openaire   +2 more sources

Characterization of the human beta 3-adrenergic receptor gene.

Molecular Pharmacology, 1993
Comparison of the rodent and human beta 3-adrenergic receptor cDNAs with the respective genomic sequences has revealed unexpectedly that these genes contain two protein-coding exons. The rat gene was cloned recently and was found to contain three exons and two introns.
J G, Granneman, K N, Lahners, A, Chaudhry   +2 more
openaire   +2 more sources

Beta-3 Adrenergic Receptor Agonists Cause an Increase in Gastrointestinal Transit Time in Wild-type Mice, But Not in Mice Lacking the Beta-3 Adrenergic Receptor

The Journal of Pharmacology and Experimental Therapeutics, 1998
The effects of beta-3 adrenergic receptor (beta3-AR) agonists on gastrointestinal (GI) motility, as reported by stomach retention and intestinal transit of radiolabelled charcoal, were compared in wild-type (WT) mice and in transgenic mice lacking beta3-AR (beta3-AR[KO]) or having beta3-AR in white and brown adipose tissue only (beta3-AR[WAT+BAT ...
D S, Fletcher, M R, Candelore, D, Grujic, B B, Lowell, S, Luell, V S, Susulic, D E, Macintyre   +6 more
openaire   +2 more sources

The human β3-adrenergic receptor: relationship with atypical receptors

The American Journal of Clinical Nutrition, 1992
Atypical beta-adrenergic receptors (beta AR), different from beta 1 and beta 2ARs, have been suggested to modulate energy expenditure. We have characterized a gene coding for a third human beta AR, beta 3AR, whose sequence is 402 amino acids long and is 50.7% and 45.5% homologous to that of the human beta 1 and beta 2AR, respectively.
L J, Emorine, B, Fève, J, Pairault, M M, Briend-Sutren, C, Nahmias, S, Marullo, C, Delavier-Klutchko, D A, Strosberg   +7 more
openaire   +2 more sources

[Beta 3 adrenergic receptor polymorphism and obesity].

Nihon rinsho. Japanese journal of clinical medicine, 1998
The beta 3-adrenoceptor plays a significant role in the control of lipolysis and thermogenesis in the brown adipose tissue of rodents and humans. In human beta 3-adrenoceptor, a Trp to Arg replacement has recently been discovered. This change which occurs at position 64, in the first coding exon, has been correlated with increased weight gain ...
T, Yoshida, T, Umekawa
openaire   +1 more source