Results 151 to 160 of about 206,749 (211)
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Molecular structure of the .beta.-adrenergic receptor
Biochemistry, 1985The beta-adrenergic receptor from several tissues has been purified to homogeneity or photoaffinity radiolabeled and its subunit molecular weight determined by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis. In this study we have examined the oligomeric structure of nondenatured beta 1- and beta 2-adrenergic receptor proteins, as ...
Darrell R. McCaslin +6 more
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Tocolysis with beta-adrenergic receptor agonists
Seminars in Perinatology, 2001Beta-adrenergic receptor agonists have been used for tocolysis in the setting of preterm labor for more than three decades. One of these agents, ritodrine hydrochloride, is the only Federal Drug Administration (FDA) approved drug for the treatment of preterm labor.
Julian T. Parer, Aaron B. Caughey
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Antibodies to Beta-Adrenergic Receptors
1991Contemporary biochemists and molecular biologists strive to understand the relationship between the function and the detailed chemical structure of macromolecules. Whereas chemical and direct physical analyses are employed to probe molecular structure, specific antibodies to proteins have been invaluable reagents in the determination of the fine ...
Harvey J. Brandwein +2 more
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BETA‐ADRENERGIC RECEPTOR ANTAGONISM IN MYOPIA*
Ophthalmic and Physiological Optics, 1987Abstract— A previous study has demonstrated that timolol maleate (0.5%), a non‐selective beta‐adrenergic antagonist, produces in emmetropes a significant reduction in accommodative convergence (AC) during the initial four minutes of a near‐vision task.
Mark Rosenfield, Bernard Gilmartin
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The Beta-Adrenergic Receptor in Heart Failure
Hospital Practice, 1983Although the role of the autonomic nervous system in the pathophysiology of heart failure has been studied for decades, only within the past few years have adrenergic receptors and their alterations occupied center stage. There is now considerable evidence linking such receptors to many of the phenomena of heart failure; recent work appears to have ...
Robert J. Lefkowitz, James A. Heinsimer
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Modulation of porcine adipocyte beta-adrenergic receptors by a beta-adrenergic agonist.
Journal of Animal Science, 2000Mammalian cells have several mechanisms to decrease the response to beta-adrenergic agonists. Agonists are metabolized or taken up by nerve endings. The beta-adrenergic receptors (betaAR) are inactivated by phosphorylation and removed from the cell membrane, and synthesis is decreased or degradation is increased.
Shih-Torng Ding +3 more
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Perspectives in adrenergic beta‐receptor blockade
Clinical Pharmacology & Therapeutics, 1969The adrenergic ß‐receptor blocking drugs currently undergoing clinical evaluation are classified in relation to their pharmacological properties. Particular consideration is given to those pharmacological properties that may be of importance in the clinical application of these drugs.
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Clinical Pharmacology and Therapeutics, 1986
Tertatolol is a potent new beta-blocker with no intrinsic sympathomimetic activity or beta 1/beta 2-receptor subtype selectivity. When given at therapeutic doses (5 mg/day) to human subjects it induced a reduction in the beta-adrenergic receptor number measured by 3H-CGP 12177 specific binding, without any change in the affinity on intact lymphocytes ...
DE BLASI, ANTONIO +5 more
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Tertatolol is a potent new beta-blocker with no intrinsic sympathomimetic activity or beta 1/beta 2-receptor subtype selectivity. When given at therapeutic doses (5 mg/day) to human subjects it induced a reduction in the beta-adrenergic receptor number measured by 3H-CGP 12177 specific binding, without any change in the affinity on intact lymphocytes ...
DE BLASI, ANTONIO +5 more
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Solubilization of a mammalian ?-adrenergic receptor
Naunyn-Schmiedeberg's Archives of Pharmacology, 1978Binding sites for iodohydroxybenzylpindolol with characteristics of a beta2-adrenergic receptor have been identified in a crude membrane fraction from guinea-pig lung. The binding sites could be solubilized by treatment of the membrane fraction with digitonin.
J, Kleinstein +3 more
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Pharmacogenetics of Beta-1- and Beta-2-Adrenergic Receptors
Pharmacology, 2000β<sub>1</sub>- and β<sub>2</sub>-adrenergic receptors are G protein-coupled receptors expressed throughout the body and serve as receptors for the catecholamines epinephrine and norepinephrine. They are targets for therapeutive agonists and/or antagonists in treatment of heart failure and asthma.
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