Results 181 to 190 of about 2,465,843 (248)

Regulation of Adrenergic Receptors [PDF]

, 1981
Transmission of intercellular messages by the adrenergic mediators, epinephrine and norepinephrine, is a ubiquitous phenomenon in vertebrates which continues to invoke investigative effort after many years of research. It has become apparent that both the release and biological actions of these mediators are modulated very specifically by ...
Robert J. Lefkowitz, Albert O. Davies
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Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.

Science, 1992
The rate and extent of the agonist-dependent phosphorylation of beta 2-adrenergic receptors and rhodopsin by beta-adrenergic receptor kinase (beta ARK) are markedly enhanced on addition of G protein beta gamma subunits.
J. Pitcher, James Inglese, J. B. Higgins, J. Arriza, P. Casey, C. Kim, J. Benovic, M. Kwatra, M. Caron, R. Lefkowitz   +9 more
semanticscholar   +1 more source

Structure of β-Adrenergic Receptors

2013
β-Adrenergic receptors (βARs) control key physiological functions by transducing signals encoded in catecholamine hormones and neurotransmitters to activate intracellular signaling pathways. As members of the large family of G protein-coupled receptors (GPCRs), βARs have a seven-transmembrane helix topology and signal via G protein- and arrestin ...
Brueckner Florian, Piscitelli Chayne L., Tsai Chingju, Standfuss Jörg, Deupí Xavier, Schertler Gebhard FX X   +5 more
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The β-Adrenergic Receptors

Herz, 2002
The beta-adrenergic receptors of the myocardium play an important role in the regulation of heart function. The beta-adrenergic receptors belong to the family of G-protein coupled receptors. Three subtypes have been distinguished (beta1-, beta2-, and beta3-adrenoceptors).
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Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.

Science, 1988
The alpha 2 and beta 2 adrenergic receptors, both of which are activated by epinephrine, but which can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on the adenylyl cyclase system.
B. Kobilka, T. S. Kobilka, K. Daniel, J. Regan, M. Caron, R. Lefkowitz   +5 more
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Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury.

Science, 1991
The mechanisms by which peripheral nerve injuries sometimes lead to causalgia, aberrant burning pain peripheral to the site of nerve damage, are uncertain, although the sympathetic nervous system is known to be involved.
J. Sato, E. Perl
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Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

Science, 1999
The Ras-dependent activation of mitogen-activated protein (MAP) kinase pathways by many receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins) requires the activation of Src family tyrosine kinases.
L. Luttrell, S. Ferguson, Y. Daaka, W. Miller, Stuart Maudsley, G. D. Della Rocca, F. Lin, H. Kawakatsu, K. Owada, D. Luttrell, M. Caron, R. Lefkowitz   +11 more
semanticscholar   +1 more source

Adrenergic Receptors and Kinins

1968
Epinephrine, as it is known, exhibits a diphasic effect on the blood pressure. In hypertensive patients, if small amounts of epinephrine are used, the hypotension is more evident than hypertension (Greppi 1932, Goldenberger et al. 1948). The effect of nor-adrenaline is simply monophasic.
Federigo Sicuteri, Marcello Fanciullacci, G. Franchi, N. Siddel, P. L. Del Bianco   +4 more
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Adrenergic receptors in the veins of the dog

European Journal of Pharmacology, 1969
Abstract The actions of catecholamines and adrenergic blocking drugs on the veins of the dog (posterior vena cava, portal vein, femoral vein, lateral saphenous vein) were studied in vitro . In these experiments quantitative and qualitative differences were found. Superficial veins were more sensitive.
Serafim Guimarães, Walter Osswald
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Beta Adrenergic Receptors

2014
β-Adrenergic receptors (β-ARs) have a key position not in to the overall regulation of cardiac function and have been shown to play an important role in various cardiac diseases and heart failure in particular. Beta adrenergic receptors (β-ARs) belong to the G protein-coupled receptor (GPCR) superfamily with widespread expression and cardiovascular ...
Konstantinos Makaritsis, Filippos Triposkiadis   +1 more
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