Results 191 to 200 of about 168,706 (292)

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Artificial Organs, EarlyView.
This study aimed to investigate the influence of warm ischemic injury on renal vascular responsiveness to vasoactive drugs during normothermic machine perfusion (NMP). We found that the vascular responses to dopamine and norepinephrine could be used as objective indicators to assess kidney viability during NMP.
Isa M. van Tricht, Baran Ogurlu, Silke S. M. Wolfswinkel, Henri G. D. Leuvenink, Cyril Moers   +4 more
wiley   +1 more source

Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness. [PDF]

Crit Care
Kleyman A, Pisciotta W, Gaupp C, Khaliq W, Hofmaenner D, Brealey D, Pinto BB, Andreis DT, Waugh MG, Melis MJ, Miller M, Mehmetaj K, Bauer M, Press A, Singer M.   +14 more
europepmc   +1 more source

The interaction between neurotransmitter receptor activity and amyloid-β pathology in Alzheimer's disease. [PDF]

J Alzheimers Dis
Nong Y, Kim JS, Jia L, Arancio O, Wang Q.   +4 more
europepmc   +1 more source

Safety pharmacology of acute mescaline administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Psychedelics, including mescaline, may serve as novel treatments for depression and anxiety. However, data is scarce on the safety of mescaline. Methods The present pooled analysis included two double‐blind, randomized, placebo‐controlled studies with a total of 48 participants and 96 mescaline administrations. Single oral‐dose administrations (n =
Aaron Klaiber, Mélusine Humbert‐Droz, Laura Ley, Yasmin Schmid, Matthias E. Liechti   +4 more
wiley   +1 more source

β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia. [PDF]

Am J Physiol Heart Circ Physiol
Jacob DW, Shariffi B, Bond BJ, Boyes NG, Martin SA, Gonsalves AM, Harper JL, Bostick BP, Limberg JK.   +8 more
europepmc   +1 more source

Advances in the treatment of malignant tumors with neurological drugs. [PDF]

Discov Oncol
Li Y, Na J, Zhong L, Zhao Y.
europepmc   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

The Use of Ketamine and Dexmedetomidine in Cesarean Section: A Narrative Review of Clinical Applications and Safety Considerations. [PDF]

Anesth Pain Med
Kareem Oleiwi Atabi T, Jabbari A, Ghorbani Gholiabad S, Bader Gazal H, Movafegh A.   +4 more
europepmc   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source