Effect of intracerebroventricular (ICV) injection of adrenomedullin and its interaction with NPY and CCK pathways on food intake regulation in neonatal layer-type chicks [PDF]
Poultry Science: Adrenomedullin has various physiological roles including appetite regulation. The objective of present study was to determine the effects of ICV injection of adrenomedullin and its interaction with NPY and CCK receptors on food intake regulation.
Maryam Soleymani Zahed +2 more
doaj +2 more sources
Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications [PDF]
The Journal of Headache and PainBackground Different responses in human coronary arteries (HCA) and human middle meningeal arteries (HMMA) were observed for some of the novel CGRP receptor antagonists, the gepants, for inhibiting CGRP-induced relaxation.
Tessa de Vries +6 more
doaj +2 more sources
Male-female comparison of vasomotor effects of circulating hormones in human intracranial arteries [PDF]
The Journal of Headache and PainBackground The purpose of this study was to examine whether there are sex differences in vasomotor responses and receptor localization of hormones and neuropeptides with relevance to migraine (vasopressin, oxytocin, estrogen, progesterone, testosterone ...
Jacob C. A. Edvinsson +3 more
doaj +2 more sources
Unraveling the role of GPCR signaling in metabolic reprogramming and immune microenvironment of lung adenocarcinoma: a multi-omics study with experimental validation [PDF]
Frontiers in ImmunologyBackgroundLung adenocarcinoma (LUAD) is characterized by metabolic and immune heterogeneity, driving tumor progression and therapy resistance. While G protein-coupled receptors (GPCR) signaling is known to regulate metabolism and immunity in cancers, its
Zhaoxuan Wang +4 more
doaj +2 more sources
Sex differences in expression of CGRP family of receptors and ligands in the rat trigeminal system [PDF]
The Journal of Headache and PainBackground Calcitonin gene-related peptide (CGRP) is part of the calcitonin peptide family, which includes calcitonin (CT), amylin (AMY), and adrenomedullin (ADM). CGRP and its receptor are highly present in the trigeminovascular system (TVS).
Aida Maddahi +2 more
doaj +2 more sources
Plasma Clearance of Intravenously Infused Adrenomedullin in Rats with Acute Renal Failure
Biomolecules, 2022 Plasma adrenomedullin concentrations are reportedly elevated in patients with renal failure; however, the underlying mechanism is unclear. In this study, we investigated the plasma clearance of synthetic human adrenomedullin (AM) in two models of rats ...
Hiroshi Hosoda +2 more
doaj +1 more source
Gel-forming antagonist provides a lasting effect on CGRP-induced vasodilation
Frontiers in Pharmacology, 2022 Migraine affects ∼15% of the adult population, and the standard treatment includes the use of triptans, ergotamines, and analgesics. Recently, CGRP and its receptor, the CLR/RAMP1 receptor complex, have been targeted for migraine treatment due to their ...
Chia Lin Chang +2 more
doaj +1 more source
Future targets for migraine treatment beyond CGRP
The Journal of Headache and Pain, 2023 Background Migraine is a disabling and chronic neurovascular headache disorder. Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a pivotal role in the pathogenesis of migraine.
Linda Al-Hassany +17 more
doaj +1 more source
КардиоСоматика, 2022 It has been proven that in patients with heart failure (HF), there is an increased level of adrenomedullin (ADM) in plasma. Biomarker indices correlate with the severity of hemodynamic dysfunction, as well as with neurohumoral indices, which are ...
Amina M. Alieva +7 more
doaj +1 more source
Calcitonin receptor-like receptor is expressed on gastrointestinal immune cells [PDF]
, 2002 Background/Aims: Pharmacological and morphological studies suggest that the gut mucosal immune system and local neuropeptide-containing neurones interact.
Göke, B. +5 more
core +1 more source