Brazilian Journal of Medical and Biological Research, 2014 The aim of the present study was to determine the mechanisms underlying the relaxant effect of adrenomedullin (AM) in rat cavernosal smooth muscle (CSM) and the expression of AM system components in this tissue.
L.N. Leite +4 more
doaj +1 more source
Adrenomedullin receptors on human T cells are glucocorticoid-sensitive
International Immunopharmacology, 2012 Adrenomedullin (AM) is a novel vasodilatatory peptide which acts primarily through the calcitonin receptor-like receptor (CLR) in combination with either receptor-activity-modifying-protein (RAMP) 2 or 3 (forming receptors, AM(1) and AM(2) respectively).
Liverani, Elisabetta +2 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 3, 14 January 2026.A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni +6 more
wiley +1 more source
Calcitonin Gene-Related Peptide Receptor Antagonists: Beyond Migraine Pain—A Possible Analgesic Strategy for Osteoarthritis? [PDF]
, 2013 Osteoarthritis (OA) pain is poorly understood and managed, as current analgesics have only limited efficacy and unwanted side effect profiles. A broader understanding of the pathological mechanisms driving OA joint pain is vital for the development of ...
C. M. Bullock, S. Kelly
core +1 more source
Toward Implantation‐Assisting Technologies: Lessons From In Vivo and Ex Vivo Models
Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.ABSTRACT Background Despite advances in assisted reproductive technology (ART), embryo implantation remains inefficient and represents a major barrier to successful pregnancy. Recurrent implantation failure persists even after transfer of high‐quality embryos, reflecting an incomplete understanding of the molecular mechanisms governing implantation ...
Takehiro Hiraoka +2 more
wiley +1 more source
Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate [PDF]
, 1999 Adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP) are two recently discovered hypotensive peptides translated from the same message transcript (preproAM mRNA).
Calvo, A. (Alfonso) +5 more
core +1 more source
Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study [PDF]
, 2015 published_or_final_versio
Cheung, ANY +7 more
core +1 more source
Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]
, 2008 Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Hongsui Wu +8 more
core +1 more source
G protein-coupled receptors: what a difference a 'partner' makes [PDF]
, 2014 G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately,
Abu-Helo +190 more
core +3 more sources
Migraine-provoking substances evoke periorbital allodynia in mice
The Journal of Headache and Pain, 2019 Background Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks.
Francesco De Logu +6 more
doaj +1 more source