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Adrenomedullin receptors : pharmacological features and possible pathophysiological roles

Adrenomedullin receptors : pharmacological features and possible pathophysiological roles
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Adrenomedullin: receptor and signal transduction

Biochemical Society Transactions, 2002
Adrenomedullin is a vascular tissue peptide and a member of the calcitonin family of peptides, which includes calcitonin, calcitonin-gene-related peptide (CGRP) and amylin. Its many biological actions are mediated via CGRP type 1 (CGRP1) receptors and by specific adrenomedullin receptors.
D M, Smith, H A, Coppock, D J, Withers, A A, Owji, D L, Hay, T P, Choksi, P, Chakravarty, S, Legon, D R, Poyner   +8 more
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Desensitisation of adrenomedullin and CGRP receptors

Regulatory Peptides, 2003
Adrenomedullin (AM), a potent vasoactive peptide, is elevated in certain disease states such as sepsis. Its role as a physiologically relevant peptide has been confirmed with the advent of the homozygous lethal AM peptide knockout mouse. So far, there have been few and conflicting studies which examine the regulatory role of AM at the receptor level ...
Debbie L, Hay, David R, Poyner, David M, Smith   +2 more
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Adrenomedullin receptors: molecular identity and function

Peptides, 2001
Since its discovery in 1993 adrenomedullin (AM) has been the subject over 600 published articles. This multifunctional peptide has powerful vasodilator actions and recent evidence from AM gene-deleted mice suggest that AM plays an essential role in vascular development.
D L, Hay, D M, Smith
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Adrenomedullin receptors in rat cerebral microvessels

Molecular Brain Research, 2000
To characterize the sites of action of adrenomedullin (AM) in the cerebral microvasculature, we studied the effect of AM on cyclic AMP (cAMP) level as well as expression of AM and its receptor in the rat cerebral microvessels. The microvessels were prepared from rat cerebral cortex by albumin flotation and glass bead filtration technique.
H, Kobayashi, S, Minami, R, Yamamoto, K, Masumoto, T, Yanagita, Y, Uezono, K, Tsuchiya, M, Mohri, K, Kitamura, T, Eto, A, Wada   +10 more
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Adrenomedullin mediates vasodilation via CGRP1 receptors

Life Sciences, 1994
Adrenomedullin is a recently discovered 52 amino acid polypeptide with potent hypotensive activity. The peptide possesses 21% homology with the amino acid sequence of human calcitonin gene-related peptide-alpha (hCGRP-alpha). In 125I-hCGRP-alpha receptor binding experiments using membranes from human neuroblastoma cells (SK-N-MC) adrenomedullin is a ...
M, Entzeroth, H N, Doods, H A, Wieland, W, Wienen   +3 more
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Adrenomedullin receptors in rat choroid plexus

Neuroscience Letters, 2001
To characterize transmembrane signaling of adrenomedullin (AM) in the choroid plexus, we studied the effects of AM on cyclic AMP (cAMP) and cyclic GMP (cGMP) levels as well as expression of mRNA for AM receptor in the rat choroid plexus slices. AM or calcitonin gene-related peptide (CGRP) increased cAMP (but not cGMP) level in a concentration-dependent
H, Kobayashi, S, Shiraishi, S, Minami, H, Yokoo, T, Yanagita, T, Saitoh, M, Mohri, A, Wada   +7 more
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Expression of the Rat Adrenomedullin Receptor or a Putative Human Adrenomedullin Receptor Does Not Correlate with Adrenomedullin Binding or Functional Response

Biochemical and Biophysical Research Communications, 1998
There has been considerable difficulty in defining distinct adrenomedullin (AM) binding sites and function in vivo. However, a rat adrenomedullin receptor (rAMR) and a putative human adrenomedullin receptor (hAMR) have recently been reported. We attempted to confirm and extend the pharmacological characterization of these cloned receptors.
S P, Kennedy, D, Sun, J J, Oleynek, C F, Hoth, J, Kong, R J, Hill   +5 more
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Effect of adrenomedullin receptor and calcitonin gene-related peptide receptor antagonists on centrally mediated adrenomedullin renal action

Brain Research Bulletin, 2001
To determine pharmacological specificity of intracerebroventricular (IVT) administration of adrenomedullin (AM) on water and sodium excretion, studies were performed in rats pretreated with AM (22-52), a putative AM-receptor antagonist or CGRP(8-37), a ligand that preferentially antagonizes the CGRP(1)-receptor subtype.
E, Diaz, A, Israel
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