Results 171 to 180 of about 9,446 (221)

The adrenomedullin receptor acts as clearance receptor in pulmonary circulation

Biochemical and Biophysical Research Communications, 2002
Adrenomedullin (AM) is a powerful pulmonary vasodilator with antimitogenic properties. We investigated the role of the AM receptor (AMR) and the calcitonin gene-related peptide type-1 receptor (CGRP1R) in regulating pulmonary vascular AM levels. The AMR antagonist hAM(22-52) (120 nmol/L) significantly elevated AM release compared with controls to 250 ...
Thomas, Dschietzig, Hamid Adib, Azad, Louay, Asswad, Claudia, Böhme, Cornelia, Bartsch, Gert, Baumann, Karl, Stangl   +6 more
openaire   +2 more sources

Adrenomedullin Selectivity of Calcitonin-like Receptor/Receptor Activity Modifying Proteins

Hypertension Research, 2003
Co-expression of an initially orphan calcitonin receptor-like (CL)1 receptor with individual receptor-activity-modifying proteins (RAMP)1, -2 and -3 results in CL receptor/RAMP1, -2 and -3 proteins at the cell surface. The RAMP define the selectivity of the CL receptor for the vasodilatory peptides adrenomedullin (AM) and calcitonin gene-related ...
Roman, Muff, Walter, Born, Jan A, Fischer   +2 more
openaire   +2 more sources

Adrenomedullin receptors: pharmacological features and possible pathophysiological roles

Peptides, 2004
Three receptor activity modifying proteins (RAMPs) chaperone calcitonin-like receptor (CLR) to the cell surface. RAMP2 enables CLR to form an adrenomedullin (AM)-specific receptor that is sensitive to AM-(22-52) (AM(1) receptor). RAMP3 enables CLR to form an AM receptor sensitive to both calcitonin gene-related peptide (CGRP)-(8-37) and AM-(22-52) (AM ...
Kenji, Kuwasako, Yuan-Ning, Cao, Yasuko, Nagoshi, Kazuo, Kitamura, Tanenao, Eto   +4 more
openaire   +2 more sources

Adrenomedullin and related peptides: receptors and accessory proteins

Peptides, 2001
Adrenomedullin (AM), alpha- and beta-calcitonin gene-related peptide (CGRP), amylin and calcitonin (CT) are structurally and functionally related peptides. The structure of a receptor for CT (CTR) was elucidated in 1991 through molecular cloning, but the structures of the receptors for the other three peptides had yet to be elucidated. The discovery of
R, Muff, W, Born, J A, Fischer
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Receptors for adrenomedullin in human vascular endothelial cells

European Journal of Pharmacology: Molecular Pharmacology, 1995
Accumulation of the intracellular cyclic AMP (cAMP) was measured in cultured endothelial cells of the human umbilical vein following the incubation with adrenomedullin, a newly discovered hypotensive peptide, to determine the presence of specific receptors for adrenomedullin.
J, Kato, K, Kitamura, K, Kangawa, T, Eto
openaire   +2 more sources

[Adrenomedullin receptors].

Nihon rinsho. Japanese journal of clinical medicine, 1998
Adrenomedullin(AM) is a potent hypotensive peptide originally isolated from human pheochromocytoma. AM exerts various biological actions such as vasodilation, bronchodilation and natriuresis, by stimulating cAMP production and increasing free Ca2+ levels through the specific receptors.
H, Murabe, M, Mukoyama, I, Tanaka, K, Nakao   +3 more
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Effects of Endothelin on Adrenomedullin Secretion and Expression of Adrenomedullin Receptors in Rat Cardiomyocytes

Biochemical and Biophysical Research Communications, 2001
Both endothelin (ET) and adrenomedullin (AM), produced by cardiac myocytes, are thought to be locally-acting hormones in the heart. Recently, calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) have been shown to function together to serve as AM receptors stimulating cAMP production.
K, Mishima, J, Kato, K, Kuwasako, K, Ito, T, Imamura, K, Kitamura, T, Eto   +6 more
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The Pharmacology of Adrenomedullin Receptors and Their Relationship to CGRP Receptors

Journal of Molecular Neuroscience, 2004
Adrenomedullin (AM) has two specific receptors formed by the calcitonin-receptor-like receptor (CL) and receptor activity-modifying protein (RAMP) 2 or 3. These are known as AM1 and AM2 receptors, respectively. In addition, AM has appreciable affinity for the CGRP1 receptor, composed of CL and RAMP1.
Debbie L, Hay, Alex C, Conner, Stephen G, Howitt, David M, Smith, David R, Poyner   +4 more
openaire   +2 more sources

Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle

Clinical Science, 1999
The prepro-adrenomedullin (prepro-AM) gene encodes several biologically active peptides, including the potent vasodilator AM. At least part of the vasodilator action of AM appears to be mediated via interactions with receptors on vascular smooth muscle cells (VSMC); however, the specific receptors involved are not known.
Tang, F, Autelitano, DJ
openaire   +4 more sources

Secretory and vascular effects of adrenomedullin in gastric ulcer: role of CGRP- and adrenomedullin-receptors

Peptides, 2003
Adrenomedullin prevents damage of gastric mucosa in either reserpine-treated or pylorus-ligated rats. Pre-treatment with CGRP(8-37) resulted in a decrease of the gastro-protective effect of adrenomedullin in both models and reversed the inhibitory effect of adrenomedullin on gastric acid output in the pylorus-ligated rats.
Salvatore, Salomone, Antonina, Caruso, Giuseppa, Martinez, Vincenza Maria, Cutuli, Agata, Prato, Alfredo, Bianchi, Matilde, Amico-Roxas, Giuseppe, Clementi   +7 more
openaire   +2 more sources