Results 21 to 30 of about 9,446 (221)

Adrenomedullin functions as an important tumor survival factor in human carcinogenesis [PDF]

, 2002
Adrenomedullin (AM) is a pluripotent regulatory peptide initially isolated from a human pheochromocytoma (adrenal tumor) and subsequently shown to play a critical role in cancer cell division, tumor neovascularization, and circumvention of programmed ...
Cuttitta, F. (Frank), Elssasser, T. (T.), Garayoa, M. (Mercedes), Julian, M. (Miguel), Martinez, A. (Alfredo), Montuenga-Badia, L.M. (Luis M.), Pio, R. (Rubén), Zudaire, E. (Enrique)   +7 more
core   +1 more source

Apocrine glands in the eyelid of primates contribute to the ocular host defense [PDF]

, 2004
Apocrine glands of Moll are regular components of primate eyelids. We studied the distribution and localization of these glands in three different primate species, the common marmoset, the rhesus monkey, and the hamadryas baboon.
Stoeckelhuber, B. M., Stoeckelhuber, M., Welsch, U.   +2 more
core   +1 more source

Cgrp Characterization And Classification

The Scientific World Journal, 2001
The peptide CGRP is thought to be an agonist at a number of receptors including its own as well as those for adrenomedullin and amylin. CGRP is thought to act through its own receptors if it is antagonized by the truncated peptide CGRP8-37 although this ...
Ian Marshall
doaj   +1 more source

Adrenomedullin inhibits prostate cancer cell proliferation through a cAMP-independent autocrine mechanism [PDF]

, 2004
Adrenomedullin (AM) is a multifunctional peptide expressed in the normal and malignant prostate, and in prostate cancer cells. To elucidate the potential role of AM in prostate cancer, we have transfected the human AM gene into PC-3, DU 145, and LNCaP ...
Abasolo, I. (Ibane), Calvo, A. (Alfonso), Montuenga-Badia, L.M. (Luis M.), Wang, Z. (Zhou)   +3 more
core   +1 more source

Amylin: Localization, Effects on Cerebral Arteries and on Local Cerebral Blood Flow in the Cat

The Scientific World Journal, 2001
Amylin and adrenomedullin are two peptides structurally related to calcitonin gene-related peptide (CGRP). We studied the occurrence of amylin in trigeminal ganglia and cerebral blood vessels of the cat with immunocytochemistry and evaluated the role of ...
Lars Edvinsson, Peter J. Goadsby, Rolf Uddman   +2 more
doaj   +1 more source

Overexpression of adrenomedullin gene markedly inhibits proliferation of PC3 prostate cancer cells in vitro and in vivo [PDF]

, 2003
The expression of the gene encoding adrenomedullin (AM), a multifunctional peptide hormone, in the prostate is localized to the epithelial cells. Prostate cancer cells are derived from prostatic epithelial cells. To elucidate the potential role of the AM
Abasolo, I. (Ibane), Calvo, A. (Alfonso), Cuttitta, F. (Frank), Haleem, R. (R.), Kozlowski, J.M. (James M.), Montuenga-Badia, L.M. (Luis M.), Pio, R. (Rubén), Wang, Z. (Zhou), Xiao, W. (Weihua), Yang, L. (Luping)   +9 more
core   +1 more source

Signalling by CGRP and Adrenomedullin in the Cerebellum and Other Systems

The Scientific World Journal, 2001
The best characterised signalling pathway activated by both CGRP and adrenomedullin is stimulation of adenylate cyclase via Gs. However, it is clear that in some circumstances the peptides can activate other signal transduction pathways, e.g., increases ...
David Poyner, Heather Cater, Nick Hartell, Alex Conner, Debbie Hay, Steve Howitt, Dave Smith   +6 more
doaj   +1 more source

Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo

Frontiers in Pharmacology, 2022
Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as anti ...
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Debbie L. Hay, Kerry M. Loomes   +13 more
doaj   +1 more source

The role of ubiquitination and hepatocyte growth factor-regulated tyrosine kinase substrate in the degradation of the adrenomedullin type I receptor [PDF]

, 2017
Calcitonin receptor-like receptor (CLR) and the receptor activity-modifying protein 2 (RAMP2) comprise a receptor for adrenomedullin (AM). Although it is known that AM induces internalization of CLR•RAMP2, little is known about the molecular mechanisms ...
A Gullapalli, A Hershko, A Marchese, A Marchese, AC Hanyaloglu, AC Hocke, B Goulet, B Hasdemir, B Hasdemir, B Sehat, B Temmesfeld-Wollbruck, BE Padilla, BL Wolfe, EF Grady, EW Ades, GS Cottrell, IL Goldknopf, J Trejo, JM Bomberger, JN Hislop, JN Hislop, JN Hislop, K Chaturvedi, K Haglund, K Kitamura, K Kuwasako, K Kuwasako, K Shtiegman, KE Longva, KG Bache, KM Caron, L Guery, L Hicke, LM McLatchie, M Christ-Crain, M Christ-Crain, M Komada, M Tanowitz, MR Dores, MR Dores, N Sirisaengtaksin, RH Moore, RM Gage, RT Dackor, S Hippenstiel, S Urbe, SD Brain, SK Shenoy, T Koyama, TA Czyzyk, WP Dunworth, Z Xia   +51 more
core   +2 more sources

Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)

The Scientific World Journal, 2001
Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1].
Z. Razzaque, D. Shaw, M. Bock, L. Maskell, J. Pickard, D. Sirinathsinghji, J. Longmore   +6 more
doaj   +1 more source