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Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins
Neuroscience, 2009The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
Michael Hollmann +3 more
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AMPA Receptor Cycling in the Synapse
Science's STKE, 2004Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and,
Anis Contractor, Stephen F. Heinemann
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Inhibitors of AMPA and Kainate Receptors
Current Medicinal Chemistry, 2001The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
P. Krogsgaard-Larsen +2 more
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Science Signaling, 2009
A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered.
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A distinctive family of proteins involved in the assembly of the most common excitatory brain receptor has been discovered.
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Sensitivity of AMPA receptors to pentobarbital
European Journal of Pharmacology: Molecular Pharmacology, 1994The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
Lu-Yang Wang +4 more
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Stargazin and the AMPA receptor
Science, 2016Structural Biology AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking, gating, and pharmacology.
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The AMPA receptors of auditory neurons
Hearing Research, 2000The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
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AMPA Receptor Trafficking and GluR1
Science, 2005In their Research Article “Postsynaptic receptor trafficking underlying a form of associative learning” (1 Apr., p. 83), S. Rumpel et al. draw the important conclusions that “encoding of memories in the lateral amygdala is mediated by AMPA receptor trafficking” and that “synaptic incorporation of AMPARs is necessary for learning.” The key experiment ...
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European Journal of Pharmacology, 1996
A series of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) analogues were evaluated for activity at homo-oligomeric glutamate1-flop (Glu1-flop) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique.
Wahl, P +4 more
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A series of (RS)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) analogues were evaluated for activity at homo-oligomeric glutamate1-flop (Glu1-flop) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique.
Wahl, P +4 more
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Photocontrol of AMPA Receptors with a Photochromic Ligand
2014Photochromic ligands (PCLs), recently introduced by our group as a tool for researchers in neuroscience, offer the ability to control native receptors with light in a reversible fashion without the need for any genetic manipulation. Here we describe the application of the PCL Azo-Tetrazole-AMPA-3 (ATA-3) to reversibly gate native AMPA-receptors with ...
Martin Sumser, Philipp Stawski
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