Results 131 to 140 of about 86,953 (229)
Experimental Physiology, EarlyView.Abstract The pre‐hearing mouse cochlea undergoes critical periods of spontaneous Ca2+‐dependent activity that spreads across non‐sensory supporting cells and inner hair cells (IHCs). These signals have been shown to regulate not only the refinement of neural circuits along the auditory pathway towards functional maturity, but also the maturation of the
Francesca De Faveri +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend AII amacrine cells are an important class of interneuron in the vertebrate retina. In addition to traditional chemical synapses these cells communicate with other neurons and with each other via electrical synapses. (A) Electrical synapse strength between AII amacrine cells was measured using dual whole‐cell patch‐clamp ...
Chloe Cable +2 more
wiley +1 more source
ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. [PDF]
, 2016 It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the
Dickman, DK +3 more
core
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Frailty is a prevalent syndrome in older adults and is associated with increased vulnerability to adverse health outcomes. Growth differentiation factor 15 (GDF‐15), a cytokine involved in mitochondrial dysfunction and inflammation, has been proposed as a potential biomarker for age‐related conditions.
Juan Luis Sánchez‐Sánchez +6 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity
Protein Science, Volume 35, Issue 2, February 2026.Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin +3 more
wiley +1 more source
Deciphering the Transcriptomic Signatures of Aging Across Organs in Mice
Aging Cell, Volume 25, Issue 2, February 2026.Comprehensive transcriptomic profiling of eight mouse organs across six ages reveals how aging reshapes biological processes. Trajectory and network analyses distinguish shared and organ‐specific signatures, charting the molecular landscape of systemic aging.
Sarah Morsy +9 more
wiley +1 more source
Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss
Aging Cell, Volume 25, Issue 2, February 2026.Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli +3 more
wiley +1 more source
Acta Physiologica, Volume 242, Issue 2, February 2026.ABSTRACT Aim Identifying interactors in sensorimotor processing and neurotransmission remains a current challenge for understanding neural information processing and brain function. Methods To evaluate the role of p11 in sensorimotor processing and excitatory synaptic neurotransmission, neuron‐specific lentivirus‐directed p11 silencing, small ...
Esther Vilches‐Herrando +7 more
wiley +1 more source