Results 131 to 140 of about 2,321,962 (333)

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

Molecular Brain, 2018
N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission.
Sun Huang, Lina Chen, Chris Bladen, Peter K. Stys, Gerald W. Zamponi   +4 more
doaj   +1 more source

GRASP-1 A Neuronal RasGEF Associated with the AMPA Receptor/GRIP Complex [PDF]

The PDZ domain–containing proteins, such as PSD-95 and GRIP, have been suggested to be involved in the targeting of glutamate receptors, a process that plays a critical role in the efficiency of synaptic transmission and plasticity.
Dong, Hualing, Huganir, Richard L, Liao, Dezhi, Ye, Bing, Zhang, Peisu, Zhang, Xiaoqun   +5 more
core   +1 more source

Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation [PDF]

, 2006
©2006 Society for NeurosciencePrevious studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons.
Ferré, Sergi, Goldberg, Steven R., Gomes, Catarina, Hope, Bruce T., Pak, Arlene C., Quiroz, César, Ribeiro, Joaquim A.   +6 more
core   +1 more source

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro [PDF]

Proc. Int. Works. Comp. Syst. Biol. TICSP series 8 (2011) 181-184, 2018
In this work we study the excitatory AMPA, and NMDA, and inhibitory GABAA receptor mediated dynamical changes in neuronal networks of neonatal rat cortex in vitro. Extracellular network-wide activity was recorded with 59 planar electrodes simultaneously under different pharmacological conditions.
arxiv  

AMPA-Net: Optimization-Inspired Attention Neural Network for Deep Compressed Sensing [PDF]

2020 IEEE 20th International Conference on Communication Technology(Oral), 2020
Compressed sensing (CS) is a challenging problem in image processing due to reconstructing an almost complete image from a limited measurement. To achieve fast and accurate CS reconstruction, we synthesize the advantages of two well-known methods (neural network and optimization algorithm) to propose a novel optimization inspired neural network which ...
arxiv  

Molecular constituents of neuronal AMPA receptors [PDF]

The Journal of Cell Biology, 2005
Dynamic regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) underlies aspects of synaptic plasticity. Although numerous AMPAR-interacting proteins have been identified, their quantitative and relative contributions to native AMPAR complexes remain unclear.
Fukata, Yuko, Tzingounis, Anastassios V, Trinidad, Jonathan C, Fukata, Masaki, Burlingame, Alma L, Nicoll, Roger A, Bredt, David S   +6 more
openaire   +3 more sources

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, EarlyView.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

Downregulation of GluA2 AMPA receptor subunits reduces the dendritic arborization of developing spinal motoneurons. [PDF]

PLoS ONE, 2012
AMPA receptors lacking the GluA2 subunit allow a significant influx of Ca(2+) ions. Although Ca(2+)-permeable AMPA receptors are a familiar feature at early stages of development, the functional significance of these receptors during the maturation of ...
Yone J Yoon, Sheryl L White, Xianglian Ni, Alexander P Gokin, Miguel Martin-Caraballo   +4 more
doaj   +1 more source

Potential wells for AMPA receptors organized in ring nanodomains [PDF]

arXiv, 2013
By combining high-density super-resolution imaging with a novel stochastic analysis, we report here a peculiar nano-structure organization revealed by the density function of individual AMPA receptors moving on the surface of cultured hippocampal dendrites.
arxiv