Results 141 to 150 of about 55,538 (273)
Regulation of AMPA receptors and synaptic plasticity
, 2008 Neuronal activity controls the strength of excitatory synapses by mechanisms that include changes in the postsynaptic responses mediated by AMPA receptors.
Carvalho, A. L. +3 more
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European Journal of Pain, Volume 30, Issue 6, July 2026.ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian +8 more
wiley +1 more source
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses
eLifeChemical synapses are the major sites of communication between neurons in the nervous system and mediate either excitatory or inhibitory signaling.
Aya Matsui +9 more
doaj +1 more source
AMPA receptors in synaptic plasticity, memory function, and brain diseases [PDF]
Tetrameric AMPA-type ionotropic glutamate receptors are primary transducers of fast excitatory synaptic transmission in the central nervous system, and their properties and abundance at the synaptic surface are crucial determinants of synaptic efficacy ...
Khan, Zafar U. +2 more
core +1 more source
Aging Cell, Volume 25, Issue 7, July 2026.This study maps age‐aligned cochlear and vestibular decline in SAMP8 mice, linking functional impairment with synaptic vulnerability, mitochondrial ultrastructural injury, and autophagy/mitophagy–lysosome transcriptional remodeling. The findings provide an integrated framework for understanding shared inner‐ear aging trajectories.
Jingyi Xie +14 more
wiley +1 more source
Presynaptic AMPA receptors : more than just ion channels?
, 2004 AMPA receptor ion channels are of paramount importance for postsynaptic excitation. Several reports demonstrate that AMPA receptors are present in the presynaptic compartment and point to a role of these receptors in the modulation of presynaptic ...
U. Schenk, M. Matteoli
core +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, Volume 183, Issue 14, Page 3992-4005, July 2026.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
Psychedelics, entactogens and psychoplastogens for depression and related disorders
British Journal of Pharmacology, Volume 183, Issue 14, Page 3897-3919, July 2026.Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley +1 more source
Avaliação do efeito neuroprotetor da lectina de Canavalia brasiliensis (ConBr) frente à neurotoxicidade glutamatérgica [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2010Lectinas são proteínas com capacidade de ligação reversível a carboidratos ou glicoconjugados.
Russi, Michael Anderson
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